Retinoid X receptor alpha (RXR-alpha), also known as NR2B1 (nuclear receptor subfamily 2, group B, member 1) is a nuclear receptor

Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...

 that in humans is encoded by the RXRA gene.

Function

Retinoid X receptor

Retinoid X receptor

The retinoid X receptor is a type of nuclear receptor that is activated by 9-cis retinoic acid. There are three retinoic X receptors : RXR-alpha, RXR-beta, and RXR-gamma, encoded by the , , genes, respectively....

s (RXRs) and retinoic acid receptor

Retinoic acid receptor

The retinoic acid receptor is a type of nuclear receptor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. There are three retinoic acid receptors , RAR-alpha, RAR-beta, and RAR-gamma, encoded by the , , genes, respectively...

s (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid

Retinoic acid

Retinoic acid is a metabolite of vitamin A that mediates the functions of vitamin A required for growth and development. Retinoic acid is required in chordate animals which includes all higher animals from fishes to humans...

-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor

Thyroid hormone receptor

The thyroid hormone receptor is a type of nuclear receptor that is activated by binding thyroid hormone.-Function:Amongst the most important functions of thyroid hormone receptors are regulation of metabolism and heart rate...

 superfamily of transcription factor

Transcription factor

In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

s.

Interactions

Retinoid X receptor alpha has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with:

• BCL3
  BCL3
  B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin...
  
  ,
• BRD8
  BRD8
  Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.-Interactions:BRD8 has been shown to interact with Thyroid hormone receptor beta and Retinoid X receptor alpha.-Further reading:...
  
  ,
• CLOCK
  CLOCK
  Clock is a gene encoding a basic-helix-loop-helix-PAS transcription factor that affects both the persistence and period of circadian rhythms...
  
  ,
• FXR
  Farnesoid X receptor
  The bile acid receptor , also known as farnesoid X receptor or NR1H4 is a nuclear receptor that is encoded by the NR1H4 gene in humans.- Function :...
  
  
• IGFBP3
  IGFBP3
  Insulin-like growth factor-binding protein 3, also known as IGFBP3, is a protein that, in humans, is encoded by the IGFBP3 gene.- Function :...
  
  ,
• ITGB3BP
  ITGB3BP
  Centromere protein R is a protein that in humans is encoded by the ITGB3BP gene.-Interactions:ITGB3BP has been shown to interact with Retinoid X receptor gamma, Cyclin A2, NFKB1, Retinoid X receptor alpha, Thyroid hormone receptor alpha and CD61....
  
  ,
• LXR-β
  Liver X receptor beta
  Liver X receptor beta is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the gene .- Function :...
  
  ,
• MyoD
  MyoD
  MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
  
  ,
• NCOA2
  Nuclear receptor coactivator 2
  The nuclear receptor coactivator 2 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA2 in turn acylates...
  
  ,
• NCOA3
  Nuclear receptor coactivator 3
  The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' , steroid receptor coactivator-3 , or thyroid hormone receptor activator molecule 1 .-Function:NCOA3 is a transcriptional...
  
  ,
• NCOA6
  NCOA6
  Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
  
  ,
• NR4A1
  Nerve Growth factor IB
  The nerve Growth factor IB also known as Nur77 or NR4A1 is a protein that in humans is encoded by the NR4A1 gene....
  
  ,
• NFKBIB
  NFKBIB
  NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene.-Interactions:NFKBIB has been shown to interact with RELA, Retinoid X receptor alpha and IKK2.-Further reading:...
  
  ,
• NPAS2
  NPAS2
  Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.-Interactions:NPAS2 has been shown to interact with Retinoic acid receptor alpha, EP300, ARNTL and Retinoid X receptor alpha....
  
  ,
• NRIP1
  NRIP1
  Nuclear receptor-interacting protein 1 is a protein that in humans is encoded by the NRIP1 gene.RIP140 has an important role in regulating lipid and glucose metabolism, and regulates gene expression in metabolic tissues including heart, skeletal muscle, and liver.Knockout mice that completely lack...
  
  ,
• PPAR-γ
  Peroxisome proliferator-activated receptor gamma
  Peroxisome proliferator-activated receptor gamma , also known as the glitazone receptor, or NR1C3 is a type II nuclear receptor that in humans is encoded by the PPARG gene.Two isoforms of PPARG are detected in the human and in the mouse: PPAR-γ1 and...
  
  ,
• POU2F1
  POU2F1
  POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.-Interactions:POU2F1 has been shown to interact with SNAPC4, Ku80, Glucocorticoid receptor, Sp1 transcription factor, NPAT, POU2AF1, Host cell factor C1, TATA binding protein, RELA, Nuclear...
  
  ,
• PPARGC1A
  PPARGC1A
  Peroxisome proliferator-activated receptor gamma coactivator 1-alpha is a protein that in humans is encoded by the PPARGC1A gene....
  
  ,
• RAR-α
  Retinoic acid receptor alpha
  Retinoic acid receptor alpha , also known as NR1B1 is a nuclear receptor that in humans is encoded by the RARA gene.- Function :...
  
  ,
• RNF8
  RNF8
  E3 ubiquitin-protein ligase RNF8 is an enzyme that in humans is encoded by the RNF8 gene.-Interactions:RNF8 has been shown to interact with Retinoid X receptor alpha.-Further reading:- External links :...
  
  ,
• SHP
  Small heterodimer partner
  The small heterodimer partner also known as NR0B2 is a protein that in humans is encoded by the NR0B2 gene. SHP is a member of the nuclear receptor family of intracellular transcription factors. SHP is unusual for a nuclear receptor in that it lacks a DNA binding domain...
  
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• TADA3L
  TADA3L
  Transcriptional adapter 3-like is a protein that in humans is encoded by the TADA3 gene.-Interactions:TADA3L has been shown to interact with Retinoic acid receptor alpha, USP5, TAF9, Transcription initiation protein SPT3 homolog, TADA2L and Retinoid X receptor alpha.-Further reading:...
  
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• TBP
  TATA Binding Protein
  The TATA-binding protein is a general transcription factor that binds specifically to a DNA sequence called the TATA box. This DNA sequence is found about 35 base pairs upstream of the transcription start site in some eukaryotic gene promoters...
  
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• TR-β
  Thyroid hormone receptor beta
  Thyroid hormone receptor beta also known as nuclear receptor subfamily 1, group A, member 2 , is a nuclear receptor protein that in humans is encoded by the THRB gene.- Function :...
  
  ,
• TRIM24
  TRIM24
  Tripartite motif-containing 24 also known as transcriptional intermediary factor 1α is a protein that, in humans, is encoded by the TRIM24 gene.- Function :...
  
  . and
• VDR
  Calcitriol receptor
  The calcitriol receptor, also known as the vitamin D receptor and also known as NR1I1 , is a member of the nuclear receptor family of transcription factors...
  
  .

External links