Liver X receptor beta
Encyclopedia
Liver X receptor beta is a member of the nuclear receptor
family of transcription factors. LXR-β is encoded by the gene (nuclear receptor subfamily 1, group H, member 2).
s (LXRs) were originally identified as orphan
members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor
and bind to specific response element
s (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA
) and beta, are known to encode LXR proteins.
with NCOA6
and Retinoid X receptor alpha
.
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
family of transcription factors. LXR-β is encoded by the gene (nuclear receptor subfamily 1, group H, member 2).
Function
The liver X receptorLiver X receptor
The liver X receptor is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors are important regulators of cholesterol, fatty acid, and glucose homeostasis...
s (LXRs) were originally identified as orphan
Orphan receptor
An orphan receptor is an apparent receptor that has a similar structure to other identified receptors but whose endogenous ligand has not yet been identified. If a ligand for an orphan receptor is later discovered, the receptor is referred to as an "adopted orphan".-Examples:Examples of orphan...
members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor
Retinoid X receptor
The retinoid X receptor is a type of nuclear receptor that is activated by 9-cis retinoic acid. There are three retinoic X receptors : RXR-alpha, RXR-beta, and RXR-gamma, encoded by the , , genes, respectively....
and bind to specific response element
Response element
Response elements are short sequences of DNA within a gene promoter region that are able to bind a specific transcription factor and regulate transcription of genes.-Examples:Examples of response elements include:*Hormone response element...
s (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA
Liver X receptor alpha
Liver X receptor alpha is a nuclear receptor protein that in humans is encoded by the NR1H3 gene .- Expression :...
) and beta, are known to encode LXR proteins.
Interactions
Liver X receptor beta has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with NCOA6
NCOA6
Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
and Retinoid X receptor alpha
Retinoid X receptor alpha
Retinoid X receptor alpha , also known as NR2B1 is a nuclear receptor that in humans is encoded by the RXRA gene.- Function :...
.