Restricted randomization
Encyclopedia
Many processes
have more than one source of variation
in them. In order to reduce variation
in processes, these multiple sources must be understood, and that often leads to the concept of nested or hierarchical data structures. For example, in the semiconductor industry, a batch process
may operate on several wafers
at a time (wafers are said to be nested within batch). Understanding the input variables that control variation among those wafers, as well as understanding the variation across each wafer in a run, is an important part of the strategy for minimizing the total variation in the system.
The total amount of data generated per batch run will be 7 * 9 = 63 observations. One approach to analyzing these data would be to compute the mean
of all these points as well as their standard deviation
and use those results as responses for each run.
Analyzing the data as suggested above is not absolutely incorrect, but doing so loses information that one might otherwise obtain. For example, site 1 on wafer 1 is physically different from site 1 on wafer 2 or on any other wafer. The same is true for any of the sites on any of the wafers. Similarly, wafer 1 in run 1 is physically different from wafer 1 in run 2, and so on. To describe this situation one says that sites are nested within wafers while wafers are nested within runs.
As a consequence of this nesting, there are restrictions on the randomization that can occur in the experiment. This kind of restricted randomization always produces nested sources of variation. Examples of nested variation or restricted randomization discussed on this page are split-plot and strip-plot designs.
The objective of an experiment with this type of sampling plan is generally to reduce the variability due to sites on the wafers and wafers within runs (or batches) in the process. The sites on the wafers and the wafers within a batch become sources of unwanted variation and an investigator seeks to make the system robust
to those sources—in other words, one could treat wafers and sites as noise factors in such an experiment.
Because the wafers and the sites represent unwanted sources of variation and because one of the objectives is to reduce the process sensitivity to these sources of variation, treating wafers and sites as random effects in the analysis of the data is a reasonable approach. In other words, nested variation is often another way of saying nested random effects or nested sources of noise. If the factors "wafers" and "sites" are treated as random effects, then it is possible to estimate a variance component due to each source of variation through analysis of variance
techniques. Once estimates of the variance components have been obtained, an investigator is then able to determine the largest source of variation in the process under experimentation, and also determine the magnitudes of the other sources of variation in relation to the largest source.
that affect its output. Having nested random effects in a model is the same thing as having nested variation in a model.
can result in a split-plot type of design because of the way the experiment was actually executed.
In many industrial experiments, three situations often occur:
As a result, the treatment combinations might be randomized such that those treatment runs corresponding to one level of the concentration (−1) are run first. Each copper strip is individually plated, meaning only one strip at a time is placed in the solution for a given treatment combination. Once the four runs at the low level of solution concentration have been completed, the solution is changed to the high level of concentration (1), and the remaining four runs of the experiment are performed (where again, each strip is individually plated).
Once one complete replicate of the experiment has been completed, a second replicate is performed with a set of four copper strips processed for a given level of solution concentration before changing the concentration and processing the remaining four strips. Note that the levels for the remaining two factors can still be randomized. In addition, the level of concentration that is run first in the replication runs can also be randomized.
Running the experiment in this way results in a split-plot design. Solution concentration is known as the whole plot factor and the subplot factors are the current and the solution temperature.
A split-plot design has more than one size experimental unit. In this experiment, one size experimental unit is an individual copper strip. The treatments or factors that were applied to the individual strips are solution temperature and current (these factors were changed each time a new strip was placed in the solution). The other or larger size experimental unit is a set of four copper strips. The treatment or factor that was applied to a set of four strips is solution concentration (this factor was changed after four strips were processed). The smaller size experimental unit is referred to as the subplot experimental unit, while the larger experimental unit is referred to as the whole plot unit.
There are 16 subplot experimental units for this experiment. Solution temperature and current are the subplot factors in this experiment. There are four whole-plot experimental units in this experiment. Solution concentration is the whole-plot factor in this experiment. Since there are two sizes of experimental units, there are two error terms in the model, one that corresponds to the whole-plot error or whole-plot experimental unit and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA table for this experiment would look, in part, as follows:
The first three sources are from the whole-plot level, while the next 12 are from the subplot portion. A normal probability plot
of the 12 subplot term estimates could be used to look for statistically significant terms.
Running the experiment in this way also results in a split-plot design in which the whole-plot factors are now solution concentration and solution temperature, and the subplot factor is current.
In this experiment, one size experimental unit is again an individual copper strip. The treatment or factor that was applied to the individual strips is current (this factor was changed each time for a different strip within the solution). The other or larger size experimental unit is again a set of four copper strips. The treatments or factors that were applied to a set of four strips are solution concentration and solution temperature (these factors were changed after four strips were processed).
The smaller size experimental unit is again referred to as the subplot experimental unit. There are 16 subplot experimental units for this experiment. Current is the subplot factor in this experiment.
The larger-size experimental unit is the whole-plot experimental unit. There are four whole plot experimental units in this experiment and solution concentration and solution temperature are the whole plot factors in this experiment.
There are two sizes of experimental units and there are two error terms in the model: one that corresponds to the whole-plot error or whole-plot experimental unit, and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA for this experiment looks, in part, as follows:
The first three sources come from the whole-plot level and the next 5 come from the subplot level. Since there are 8 degrees of freedom
for the subplot error term, this MSE
can be used to test each effect that involves current.
Running the experiment in this way also results in a split-plot design in which the whole-plot factors are again solution concentration and solution temperature and the subplot factor is current. In this experiment, one size experimental unit is an individual copper strip. The treatment or factor that was applied to the individual strips is current (this factor was changed each time for a different strip within the solution). The other or larger-size experimental unit is a set of two copper strips. The treatments or factors that were applied to a pair of two strips are solution concentration and solution temperature (these factors were changed after two strips were processed). The smaller size experimental unit is referred to as the subplot experimental unit.
There are 16 subplot experimental units for this experiment. Current is the subplot factor in the experiment. There are eight whole-plot experimental units in this experiment. Solution concentration and solution temperature are the whole plot factors. There are two error terms in the model, one that corresponds to the whole-plot error or whole-plot experimental unit, and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA for this (third) approach is, in part, as follows:
The first four terms come from the whole-plot analysis and the next 5 terms come from the subplot analysis. Note that we have separate error terms for both the whole plot and the subplot effects, each based on 4 degrees of freedom.
As can be seen from these three scenarios, one of the major differences in split-plot designs versus simple factorial designs is the number of different sizes of experimental units in the experiment. Split-plot designs have more than one size experimental unit, i.e., more than one error term. Since these designs involve different sizes of experimental units and different variances, the standard error
s of the various mean comparisons involve one or more of the variances. Specifying the appropriate model for a split-plot design involves being able to identify each size of experimental unit. The way an experimental unit is defined relative to the design structure (for example, a completely randomized design
versus a randomized complete block design) and the treatment structure (for example, a full 23 factorial, a resolution V half fraction, a two-way treatment structure with a control group, etc.). As a result of having greater than one size experimental unit, the appropriate model used to analyze split-plot designs is a mixed model
.
If the data from an experiment are analyzed with only one error term used in the model, misleading and invalid conclusions can be drawn from the results.
The settings for a two-level factorial design for the three factors in the implant step are denoted (A, B, C), and a two-level factorial design for the three factors in the anneal step are denoted (D, E, F). Also present are interaction effects between the implant factors and the anneal factors. Therefore, this experiment contains three sizes of experimental units, each of which has a unique error term for estimating the significance of effects.
To put actual physical meaning to each of the experimental units in the above example, consider each combination of implant and anneal steps as an individual wafer. A batch of eight wafers goes through the implant step first. Treatment combination 3 in factors A, B, and C is the first implant treatment run. This implant treatment is applied to all eight wafers at once. Once the first implant treatment is finished, another set of eight wafers is implanted with treatment combination 5 of factors A, B, and C. This continues until the last batch of eight wafers is implanted with treatment combination 6 of factors A, B, and C. Once all of the eight treatment combinations of the implant factors have been run, the anneal step starts. The first anneal treatment combination to be run is treatment combination 5 of factors D, E, and F. This anneal treatment combination is applied to a set of eight wafers, with each of these eight wafers coming from one of the eight implant treatment combinations. After this first batch of wafers has been annealed, the second anneal treatment is applied to a second batch of eight wafers, with these eight wafers coming from one each of the eight implant treatment combinations. This is continued until the last batch of eight wafers has been implanted with a particular combination of factors D, E, and F.
Running the experiment in this way results in a strip-plot design with three sizes of experimental units. A set of eight wafers that are implanted together is the experimental unit for the implant factors A, B, and C and for all of their interactions. There are eight experimental units for the implant factors. A different set of eight wafers are annealed together. This different set of eight wafers is the second size experimental unit and is the experimental unit for the anneal factors D, E, and F and for all of their interactions. The third size experimental unit is a single wafer. This is the experimental unit for all of the interaction effects between the implant factors and the anneal factors.
Actually, the above description of the strip-plot design represents one block
or one replicate
of this experiment. If the experiment contains no replication and the model for the implant contains only the main effect
s and two-factor interactions, the three-factor interaction term A*B*C (1 degree of freedom) provides the error term for the estimation of effects within the implant experimental unit. Invoking a similar model for the anneal experimental unit produces the three-factor interaction term D*E*F for the error term (1 degree of freedom) for effects within the anneal experimental unit.
Process (engineering)
In engineering a process is a set of interrelated tasks that, together, transform inputs into outputs. These tasks may be carried out by people, nature, or machines using resources; so an engineering process must be considered in the context of the agents carrying out the tasks, and the resource...
have more than one source of variation
Statistical dispersion
In statistics, statistical dispersion is variability or spread in a variable or a probability distribution...
in them. In order to reduce variation
Variance reduction
In mathematics, more specifically in the theory of Monte Carlo methods, variance reduction is a procedure used to increase the precision of the estimates that can be obtained for a given number of iterations. Every output random variable from the simulation is associated with a variance which...
in processes, these multiple sources must be understood, and that often leads to the concept of nested or hierarchical data structures. For example, in the semiconductor industry, a batch process
Batch production
Batch production is a technique used in manufacturing, in which the object in question is created stage by stage over a series of workstations. Batch production is common in bakeries and in the manufacture of sports shoes, pharmaceutical ingredients , inks, paints and adhesives. In the manufacture...
may operate on several wafers
Wafer (electronics)
A wafer is a thin slice of semiconductor material, such as a silicon crystal, used in the fabrication of integrated circuits and other microdevices...
at a time (wafers are said to be nested within batch). Understanding the input variables that control variation among those wafers, as well as understanding the variation across each wafer in a run, is an important part of the strategy for minimizing the total variation in the system.
Example of nested data
Consider a batch process that uses 7 monitor wafers in each run. The plan further calls for measuring a response variable on each wafer at each of 9 sites. The organization of the sampling plan has a hierarchical or nested structure: the batch run is the topmost level, the second level is an individual wafer, and the third level is the site on the wafer.The total amount of data generated per batch run will be 7 * 9 = 63 observations. One approach to analyzing these data would be to compute the mean
Mean
In statistics, mean has two related meanings:* the arithmetic mean .* the expected value of a random variable, which is also called the population mean....
of all these points as well as their standard deviation
Standard deviation
Standard deviation is a widely used measure of variability or diversity used in statistics and probability theory. It shows how much variation or "dispersion" there is from the average...
and use those results as responses for each run.
Analyzing the data as suggested above is not absolutely incorrect, but doing so loses information that one might otherwise obtain. For example, site 1 on wafer 1 is physically different from site 1 on wafer 2 or on any other wafer. The same is true for any of the sites on any of the wafers. Similarly, wafer 1 in run 1 is physically different from wafer 1 in run 2, and so on. To describe this situation one says that sites are nested within wafers while wafers are nested within runs.
As a consequence of this nesting, there are restrictions on the randomization that can occur in the experiment. This kind of restricted randomization always produces nested sources of variation. Examples of nested variation or restricted randomization discussed on this page are split-plot and strip-plot designs.
The objective of an experiment with this type of sampling plan is generally to reduce the variability due to sites on the wafers and wafers within runs (or batches) in the process. The sites on the wafers and the wafers within a batch become sources of unwanted variation and an investigator seeks to make the system robust
Robustification
Robustification is a form of optimisation whereby a system is made less sensitive to the effects of random variability, or noise, that is present in that system’s input variables and parameters...
to those sources—in other words, one could treat wafers and sites as noise factors in such an experiment.
Because the wafers and the sites represent unwanted sources of variation and because one of the objectives is to reduce the process sensitivity to these sources of variation, treating wafers and sites as random effects in the analysis of the data is a reasonable approach. In other words, nested variation is often another way of saying nested random effects or nested sources of noise. If the factors "wafers" and "sites" are treated as random effects, then it is possible to estimate a variance component due to each source of variation through analysis of variance
Analysis of variance
In statistics, analysis of variance is a collection of statistical models, and their associated procedures, in which the observed variance in a particular variable is partitioned into components attributable to different sources of variation...
techniques. Once estimates of the variance components have been obtained, an investigator is then able to determine the largest source of variation in the process under experimentation, and also determine the magnitudes of the other sources of variation in relation to the largest source.
Nested random effects
If an experiment or process has nested variation, the experiment or process has multiple sources of random errorRandom error
Random errors are errors in measurement that lead to measurable values being inconsistent when repeated measures of a constant attribute or quantity are taken...
that affect its output. Having nested random effects in a model is the same thing as having nested variation in a model.
Split-plot designs
Split-plot designs result when a particular type of restricted randomization has occurred during the experiment. A simple factorial experimentFactorial experiment
In statistics, a full factorial experiment is an experiment whose design consists of two or more factors, each with discrete possible values or "levels", and whose experimental units take on all possible combinations of these levels across all such factors. A full factorial design may also be...
can result in a split-plot type of design because of the way the experiment was actually executed.
In many industrial experiments, three situations often occur:
- some of the factors of interest may be 'hard to vary' while the remaining factors are easy to vary. As a result, the order in which the treatment combinations for the experiment are run is determined by the ordering of these 'hard-to-vary' factors
- experimental units are processed together as a batch for one or more of the factors in a particular treatment combination
- experimental units are processed individually, one right after the other, for the same treatment combination without resetting the factor settings for that treatment combination.
Split-plot experimental examples
An experiment run under one of the above three situations usually results in a split-plot type of design. Consider an experiment to examine electroplating of aluminum (non-aqueous) on copper strips. The three factors of interest are: current (A); solution temperature (T); and the solution concentration of the plating agent (S). Plating rate is the measured response. There are a total of 16 copper strips available for the experiment. The treatment combinations to be run (orthogonally scaled) are listed below in standard order (i.e., they have not been randomized):| Current | Temperature | Concentration |
|---|---|---|
| −1 | −1 | −1 |
| −1 | −1 | +1 |
| −1 | +1 | −1 |
| −1 | +1 | +1 |
| +1 | −1 | −1 |
| +1 | −1 | +1 |
| +1 | +1 | −1 |
| +1 | +1 | +1 |
Example: some factors hard to vary
Consider running the experiment under the first condition listed above, with the factor solution concentration of the plating agent (S) being hard to vary. Since this factor is hard to vary, the experimenter would like to randomize the treatment combinations so that the solution concentration factor has a minimal number of changes. In other words, the randomization of the treatment runs is restricted somewhat by the level of the solution concentration factor.As a result, the treatment combinations might be randomized such that those treatment runs corresponding to one level of the concentration (−1) are run first. Each copper strip is individually plated, meaning only one strip at a time is placed in the solution for a given treatment combination. Once the four runs at the low level of solution concentration have been completed, the solution is changed to the high level of concentration (1), and the remaining four runs of the experiment are performed (where again, each strip is individually plated).
Once one complete replicate of the experiment has been completed, a second replicate is performed with a set of four copper strips processed for a given level of solution concentration before changing the concentration and processing the remaining four strips. Note that the levels for the remaining two factors can still be randomized. In addition, the level of concentration that is run first in the replication runs can also be randomized.
Running the experiment in this way results in a split-plot design. Solution concentration is known as the whole plot factor and the subplot factors are the current and the solution temperature.
A split-plot design has more than one size experimental unit. In this experiment, one size experimental unit is an individual copper strip. The treatments or factors that were applied to the individual strips are solution temperature and current (these factors were changed each time a new strip was placed in the solution). The other or larger size experimental unit is a set of four copper strips. The treatment or factor that was applied to a set of four strips is solution concentration (this factor was changed after four strips were processed). The smaller size experimental unit is referred to as the subplot experimental unit, while the larger experimental unit is referred to as the whole plot unit.
There are 16 subplot experimental units for this experiment. Solution temperature and current are the subplot factors in this experiment. There are four whole-plot experimental units in this experiment. Solution concentration is the whole-plot factor in this experiment. Since there are two sizes of experimental units, there are two error terms in the model, one that corresponds to the whole-plot error or whole-plot experimental unit and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA table for this experiment would look, in part, as follows:
| Source | DF |
|---|---|
| Replication | 1 |
| Concentration | 1 |
| Error (Whole plot) = Rep*Conc | 1 |
| Temperature | 1 |
| Rep*Temp | 1 |
| Current | 1 |
| Rep*Current | 1 |
| Temp*Conc | 1 |
| Rep*Temp*Conc | 1 |
| Temp*Current | 1 |
| Rep*Temp*Current | 1 |
| Current*Conc | 1 |
| Rep*Current*Conc | 1 |
| Temp*Current*Conc | 1 |
| Error (Subplot) = Rep*Temp*Current*Conc | 1 |
The first three sources are from the whole-plot level, while the next 12 are from the subplot portion. A normal probability plot
Normal probability plot
The normal probability plot is a graphical technique for normality testing: assessing whether or not a data set is approximately normally distributed....
of the 12 subplot term estimates could be used to look for statistically significant terms.
Example: batch process
Consider running the experiment under the second condition listed above (i.e., a batch process) for which four copper strips are placed in the solution at one time. A specified level of current can be applied to an individual strip within the solution. The same 16 treatment combinations (a replicated 23 factorial) are run as were run under the first scenario. However, the way in which the experiment is performed would be different. There are four treatment combinations of solution temperature and solution concentration: (−1, −1), (−1, 1), (1, −1), (1, 1). The experimenter randomly chooses one of these four treatments to set up first. Four copper strips are placed in the solution. Two of the four strips are randomly assigned to the low current level. The remaining two strips are assigned to the high current level. The plating is performed and the response is measured. A second treatment combination of temperature and concentration is chosen and the same procedure is followed. This is done for all four temperature / concentration combinations.Running the experiment in this way also results in a split-plot design in which the whole-plot factors are now solution concentration and solution temperature, and the subplot factor is current.
In this experiment, one size experimental unit is again an individual copper strip. The treatment or factor that was applied to the individual strips is current (this factor was changed each time for a different strip within the solution). The other or larger size experimental unit is again a set of four copper strips. The treatments or factors that were applied to a set of four strips are solution concentration and solution temperature (these factors were changed after four strips were processed).
The smaller size experimental unit is again referred to as the subplot experimental unit. There are 16 subplot experimental units for this experiment. Current is the subplot factor in this experiment.
The larger-size experimental unit is the whole-plot experimental unit. There are four whole plot experimental units in this experiment and solution concentration and solution temperature are the whole plot factors in this experiment.
There are two sizes of experimental units and there are two error terms in the model: one that corresponds to the whole-plot error or whole-plot experimental unit, and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA for this experiment looks, in part, as follows:
| Source | DF |
|---|---|
| Concentration | 1 |
| Temperature | 1 |
| Error (Whole plot) = Conc*Temp | 1 |
| Current | 1 |
| Conc*Current | 1 |
| Temp*Current | 1 |
| Conc*Temp*Current | 1 |
| Error (Subplot) | 8 |
The first three sources come from the whole-plot level and the next 5 come from the subplot level. Since there are 8 degrees of freedom
Degrees of freedom (statistics)
In statistics, the number of degrees of freedom is the number of values in the final calculation of a statistic that are free to vary.Estimates of statistical parameters can be based upon different amounts of information or data. The number of independent pieces of information that go into the...
for the subplot error term, this MSE
Mean squared error
In statistics, the mean squared error of an estimator is one of many ways to quantify the difference between values implied by a kernel density estimator and the true values of the quantity being estimated. MSE is a risk function, corresponding to the expected value of the squared error loss or...
can be used to test each effect that involves current.
Example: experimental units processed individually
Consider running the experiment under the third scenario listed above. There is only one copper strip in the solution at one time. However, two strips, one at the low current and one at the high current, are processed one right after the other under the same temperature and concentration setting. Once two strips have been processed, the concentration is changed and the temperature is reset to another combination. Two strips are again processed, one after the other, under this temperature and concentration setting. This process is continued until all 16 copper strips have been processed.Running the experiment in this way also results in a split-plot design in which the whole-plot factors are again solution concentration and solution temperature and the subplot factor is current. In this experiment, one size experimental unit is an individual copper strip. The treatment or factor that was applied to the individual strips is current (this factor was changed each time for a different strip within the solution). The other or larger-size experimental unit is a set of two copper strips. The treatments or factors that were applied to a pair of two strips are solution concentration and solution temperature (these factors were changed after two strips were processed). The smaller size experimental unit is referred to as the subplot experimental unit.
There are 16 subplot experimental units for this experiment. Current is the subplot factor in the experiment. There are eight whole-plot experimental units in this experiment. Solution concentration and solution temperature are the whole plot factors. There are two error terms in the model, one that corresponds to the whole-plot error or whole-plot experimental unit, and one that corresponds to the subplot error or subplot experimental unit.
The ANOVA for this (third) approach is, in part, as follows:
| Source | DF |
|---|---|
| Concentration | 1 |
| Temperature | 1 |
| Conc*Temp | 1 |
| Error (Whole plot) | 4 |
| Current | 1 |
| Conc*Current | 1 |
| Temp*Current | 1 |
| Conc*Temp*Current | 1 |
| Error (Subplot) | 4 |
The first four terms come from the whole-plot analysis and the next 5 terms come from the subplot analysis. Note that we have separate error terms for both the whole plot and the subplot effects, each based on 4 degrees of freedom.
As can be seen from these three scenarios, one of the major differences in split-plot designs versus simple factorial designs is the number of different sizes of experimental units in the experiment. Split-plot designs have more than one size experimental unit, i.e., more than one error term. Since these designs involve different sizes of experimental units and different variances, the standard error
Standard error
Standard error can refer to:* Standard error , the estimated standard deviation or error of a series of measurements* Standard error stream, one of the standard streams in Unix-like operating systems...
s of the various mean comparisons involve one or more of the variances. Specifying the appropriate model for a split-plot design involves being able to identify each size of experimental unit. The way an experimental unit is defined relative to the design structure (for example, a completely randomized design
Completely randomized design
In the design of experiments, completely randomized designs are for studying the effects of one primary factor without the need to take other nuisance variables into account. This article describes completely randomized designs that have one primary factor. The experiment compares the values of a...
versus a randomized complete block design) and the treatment structure (for example, a full 23 factorial, a resolution V half fraction, a two-way treatment structure with a control group, etc.). As a result of having greater than one size experimental unit, the appropriate model used to analyze split-plot designs is a mixed model
Mixed model
A mixed model is a statistical model containing both fixed effects and random effects, that is mixed effects. These models are useful in a wide variety of disciplines in the physical, biological and social sciences....
.
If the data from an experiment are analyzed with only one error term used in the model, misleading and invalid conclusions can be drawn from the results.
Strip-plot designs
Similar to a split-plot design, a strip-plot design can result when some type of restricted randomization has occurred during the experiment. A simple factorial design can result in a strip-plot design depending on how the experiment was conducted. Strip-plot designs often result from experiments that are conducted over two or more process steps in which each process step is a batch process, i.e., completing each treatment combination of the experiment requires more than one processing step with experimental units processed together at each process step. As in the split-plot design, strip-plot designs result when the randomization in the experiment has been restricted in some way. As a result of the restricted randomization that occurs in strip-plot designs, there are multiple sizes of experimental units. Therefore, there are different error terms or different error variances that are used to test the factors of interest in the design. A traditional strip-plot design has three sizes of experimental units.Strip-plot example: two steps and three factor variables
Consider the following example from the semiconductor industry. An experiment requires an implant step and an anneal step. At both the anneal and the implant steps there are three factors to test. The implant process accommodates 12 wafers in a batch, and implanting a single wafer under a specified set of conditions is not practical nor does doing so represent economical use of the implanter. The anneal furnace can handle up to 100 wafers.The settings for a two-level factorial design for the three factors in the implant step are denoted (A, B, C), and a two-level factorial design for the three factors in the anneal step are denoted (D, E, F). Also present are interaction effects between the implant factors and the anneal factors. Therefore, this experiment contains three sizes of experimental units, each of which has a unique error term for estimating the significance of effects.
To put actual physical meaning to each of the experimental units in the above example, consider each combination of implant and anneal steps as an individual wafer. A batch of eight wafers goes through the implant step first. Treatment combination 3 in factors A, B, and C is the first implant treatment run. This implant treatment is applied to all eight wafers at once. Once the first implant treatment is finished, another set of eight wafers is implanted with treatment combination 5 of factors A, B, and C. This continues until the last batch of eight wafers is implanted with treatment combination 6 of factors A, B, and C. Once all of the eight treatment combinations of the implant factors have been run, the anneal step starts. The first anneal treatment combination to be run is treatment combination 5 of factors D, E, and F. This anneal treatment combination is applied to a set of eight wafers, with each of these eight wafers coming from one of the eight implant treatment combinations. After this first batch of wafers has been annealed, the second anneal treatment is applied to a second batch of eight wafers, with these eight wafers coming from one each of the eight implant treatment combinations. This is continued until the last batch of eight wafers has been implanted with a particular combination of factors D, E, and F.
Running the experiment in this way results in a strip-plot design with three sizes of experimental units. A set of eight wafers that are implanted together is the experimental unit for the implant factors A, B, and C and for all of their interactions. There are eight experimental units for the implant factors. A different set of eight wafers are annealed together. This different set of eight wafers is the second size experimental unit and is the experimental unit for the anneal factors D, E, and F and for all of their interactions. The third size experimental unit is a single wafer. This is the experimental unit for all of the interaction effects between the implant factors and the anneal factors.
Actually, the above description of the strip-plot design represents one block
Blocking (statistics)
In the statistical theory of the design of experiments, blocking is the arranging of experimental units in groups that are similar to one another. For example, an experiment is designed to test a new drug on patients. There are two levels of the treatment, drug, and placebo, administered to male...
or one replicate
Replication (statistics)
In engineering, science, and statistics, replication is the repetition of an experimental condition so that the variability associated with the phenomenon can be estimated. ASTM, in standard E1847, defines replication as "the repetition of the set of all the treatment combinations to be compared in...
of this experiment. If the experiment contains no replication and the model for the implant contains only the main effect
Main effect
In the design of experiments and analysis of variance, a main effect is the effect of an independent variable on a dependent variable averaging across the levels of any other independent variables...
s and two-factor interactions, the three-factor interaction term A*B*C (1 degree of freedom) provides the error term for the estimation of effects within the implant experimental unit. Invoking a similar model for the anneal experimental unit produces the three-factor interaction term D*E*F for the error term (1 degree of freedom) for effects within the anneal experimental unit.
See also
- Hierarchical linear modelingHierarchical linear modelingIn statistics, hierarchical linear modeling , a form of multi-level analysis, is a more advanced form of simple linear regression and multiple linear regression. Multilevel analysis allows variance in outcome variables to be analysed at multiple hierarchical levels, whereas in simple linear and...
- Mixed-design analysis of varianceMixed-design analysis of varianceIn statistics, a mixed-design analysis of variance model is used to test for differences between two or more independent groups whilst subjecting participants to repeated measures...
- Multilevel modelMultilevel modelMultilevel models are statistical models of parameters that vary at more than one level...
- Nested case-control studyNested case-control studyA nested case control study is a variation of a case-cohort study in which only a subset of controls from the cohort are compared to the incident cases. In a case-cohort study, all incident cases in the cohort are compared to a random subset of participants who do not develop the disease of interest...