Metrophanes II served as Bishop

Bishop

A bishop is an ordained or consecrated member of the Christian clergy who is generally entrusted with a position of authority and oversight. Within the Catholic Church, Eastern Orthodox, Oriental Orthodox Churches, in the Assyrian Church of the East, in the Independent Catholic Churches, and in the...

 of Cyzicus

Cyzicus

Cyzicus was an ancient town of Mysia in Anatolia in the current Balıkesir Province of Turkey. It was located on the shoreward side of the present Kapıdağ Peninsula , a tombolo which is said to have originally been an island in the Sea of Marmara only to be connected to the mainland in historic...

 in Asia Minor

Asia Minor

Asia Minor is a geographical location at the westernmost protrusion of Asia, also called Anatolia, and corresponds to the western two thirds of the Asian part of Turkey...

 when he was called to join the delegation of bishops attending the Council of Florence

Council of Florence

The Council of Florence was an Ecumenical Council of the Roman Catholic Church. It began in 1431 in Basel, Switzerland, and became known as the Council of Ferrara after its transfer to Ferrara was decreed by Pope Eugene IV, to convene in 1438...

. He was appointed by the Emperor John VIII

John VIII Palaiologos

John VIII Palaiologos or Palaeologus , was the penultimate reigning Byzantine Emperor, ruling from 1425 to 1448.-Life:John VIII Palaiologos was the eldest son of Manuel II Palaiologos and Helena Dragaš, the daughter of the Serbian prince Constantine Dragaš...

 in May 1440 as successor to Patriarch Joseph II of Constantinople

Patriarch Joseph II of Constantinople

Joseph II was Patriarch of Constantinople from 1416 to 1439.Born the son of Ivan Shishman of Bulgaria in 1360, little is known of his early life before he became a monk on Mount Athos. He became Metropolitan of Ephesus in 1393, before being elected Patriarch of Constantinople on 21 May 1416...

 following the death of the latter in Florence

Florence

Florence is the capital city of the Italian region of Tuscany and of the province of Florence. It is the most populous city in Tuscany, with approximately 370,000 inhabitants, expanding to over 1.5 million in the metropolitan area....

. The Emperor was eager to secure help from Pope Eugene IV

Pope Eugene IV

Pope Eugene IV , born Gabriele Condulmer, was pope from March 3, 1431, to his death.-Biography:He was born in Venice to a rich merchant family, a Correr on his mother's side. Condulmer entered the Order of Saint Augustine at the monastery of St. George in his native city...

 to deal with Turkish

Ottoman Empire

The Ottoman EmpireIt was usually referred to as the "Ottoman Empire", the "Turkish Empire", the "Ottoman Caliphate" or more commonly "Turkey" by its contemporaries...

 aggression, so he forced the patriarch and all other bishops to submit to papal authority. Only one bishop did not submit: Markos Eugenikos

Mark of Ephesus

Mark of Ephesus , a 15th century Archbishop of Ephesus, is famous for his defense of Eastern Orthodoxy at the Council of Florence in spite of Byzantine Emperor John VIII Palaeologus and Pope Eugene IV...

, Metropolitan of Ephesus

Ephesus

Ephesus was an ancient Greek city, and later a major Roman city, on the west coast of Asia Minor, near present-day Selçuk, Izmir Province, Turkey. It was one of the twelve cities of the Ionian League during the Classical Greek era...

, and without his signature the document of Union between East-West fell inactive. For his submission to the Union, he was nicknamed Mitrofonos (Mother-Killer), deposed by a popular uprising and fled to the Papal court in Rome

Rome

Rome is the capital of Italy and the country's largest and most populated city and comune, with over 2.7 million residents in . The city is located in the central-western portion of the Italian Peninsula, on the Tiber River within the Lazio region of Italy.Rome's history spans two and a half...

.

Metrophanes died in Constantinople

Constantinople

Constantinople was the capital of the Roman, Eastern Roman, Byzantine, Latin, and Ottoman Empires. Throughout most of the Middle Ages, Constantinople was Europe's largest and wealthiest city.-Names:...

on August 1, 1443.