MOPP (medicine)
Encyclopedia
MOPP is a combination
chemotherapy
regimen used to treat Hodgkin's disease. The acronym is derived from the component drugs of the regimen:
The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's lymphoma treatment is ABVD
.
in the 1960s by a team that included Vincent DeVita, Jr.
.
Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain allergies
or lung
or heart
problems which prevents the use of another regimen.
(hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting, and stomachache are common, as are chills, constipation, and frequent urination
. Permanent sterility
may also result.
Combination therapy
Combination therapy or polytherapy is the use of more than one medication or other therapy. In contrast, monotherapy is any therapy which is taken by itself....
chemotherapy
Chemotherapy
Chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen....
regimen used to treat Hodgkin's disease. The acronym is derived from the component drugs of the regimen:
- Mustargen (also known as mechlorethamine, mustine, nitrogen mustard, or MSD)
- OncovinVincristineVincristine , formally known as leurocristine, sometimes abbreviated "VCR", is a vinca alkaloid from the Catharanthus roseus , formerly Vinca rosea and hence its name. It is a mitotic inhibitor, and is used in cancer chemotherapy.-Mechanism:Tubulin is a structural protein that polymerizes to...
(also known as Vincristine or VCR) - ProcarbazineProcarbazineProcarbazine Procarbazine Procarbazine (Matulane (US), Natulan (Canada), Indicarb (India) is an antineoplastic chemotherapy drug for the treatment of Hodgkin's lymphoma and certain brain cancers (such as Glioblastoma multiforme). It is a member of a group of medicines called alkylating agents. It...
(also known as Matulane or Natulan) - PrednisonePrednisonePrednisone is a synthetic corticosteroid drug that is particularly effective as an immunosuppressant drug. It is used to treat certain inflammatory diseases and some types of cancer, but has significant adverse effects...
(also known as Deltasone or Orasone)
The treatment is usually administered in four week cycles, often for six cycles. MSD and VCR are administered intravenously, while procarbazine and prednisone are pills taken orally. A newer Hodgkin's lymphoma treatment is ABVD
ABVD
ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol. It consists of concurrent treatment with the chemotherapy drugs:*Adriamycin *bleomycin...
.
History
MOPP was the first combination chemotherapy brought in that achieved a high success rate. It was developed at the National Cancer InstituteNational Cancer Institute
The National Cancer Institute is part of the National Institutes of Health , which is one of 11 agencies that are part of the U.S. Department of Health and Human Services. The NCI coordinates the U.S...
in the 1960s by a team that included Vincent DeVita, Jr.
Vincent T. DeVita
Vincent T. DeVita, Jr., MD is an internationally recognized pioneer physician in the field of oncology.DeVita earned his Bachelor of Science degree from the College of William and Mary in 1957. He was awarded his MD degree with distinction from the George Washington University School of Medicine in...
.
Although no longer the most effective combination, MOPP is still used after relapse or where the patient has certain allergies
Allergy
An Allergy is a hypersensitivity disorder of the immune system. Allergic reactions occur when a person's immune system reacts to normally harmless substances in the environment. A substance that causes a reaction is called an allergen. These reactions are acquired, predictable, and rapid...
or lung
Lung
The lung is the essential respiration organ in many air-breathing animals, including most tetrapods, a few fish and a few snails. In mammals and the more complex life forms, the two lungs are located near the backbone on either side of the heart...
or heart
Heart
The heart is a myogenic muscular organ found in all animals with a circulatory system , that is responsible for pumping blood throughout the blood vessels by repeated, rhythmic contractions...
problems which prevents the use of another regimen.
Side effects
There is 20% chance of developing a second cancer within 20 years of MOPP treatment. As a result, MOPP is rarely used any more for treatment for Hodgkin's<1>. MOPP has been known to cause alopeciaAlopecia
Alopecia means loss of hair from the head or body. Alopecia can mean baldness, a term generally reserved for pattern alopecia or androgenic alopecia. Compulsive pulling of hair can also produce hair loss. Hairstyling routines such as tight ponytails or braids may induce Traction alopecia. Both...
(hair loss) and skin sensitivity (especially to sunlight). Nausea, vomiting, and stomachache are common, as are chills, constipation, and frequent urination
Urine
Urine is a typically sterile liquid by-product of the body that is secreted by the kidneys through a process called urination and excreted through the urethra. Cellular metabolism generates numerous by-products, many rich in nitrogen, that require elimination from the bloodstream...
. Permanent sterility
Infertility
Infertility primarily refers to the biological inability of a person to contribute to conception. Infertility may also refer to the state of a woman who is unable to carry a pregnancy to full term...
may also result.