John, Crown Prince of Portugal
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John Manuel, Prince of Portugal (Portuguese: João Manuel, ʒuˈɐ̃w̃ mɐnuˈɛɫ) (3 June 1537 – 2 January 1554) was a Portuguese
Portugal
Portugal , officially the Portuguese Republic is a country situated in southwestern Europe on the Iberian Peninsula. Portugal is the westernmost country of Europe, and is bordered by the Atlantic Ocean to the West and South and by Spain to the North and East. The Atlantic archipelagos of the...

 infante (prince), the eighth son of King John III of Portugal
John III of Portugal
John III , nicknamed o Piedoso , was the fifteenth King of Portugal and the Algarves. He was the son of King Manuel I and Maria of Aragon, the third daughter of King Ferdinand II of Aragon and Queen Isabella I of Castile...

 by his wife Catherine of Austria (House of Habsburg
Habsburg
The House of Habsburg , also found as Hapsburg, and also known as House of Austria is one of the most important royal houses of Europe and is best known for being an origin of all of the formally elected Holy Roman Emperors between 1438 and 1740, as well as rulers of the Austrian Empire and...

), daughter of Philip I of Castile
Philip I of Castile
Philip I , known as Philip the Handsome or the Fair, was the first Habsburg King of Castile...

 and Joanna of Castile
Joanna of Castile
Joanna , nicknamed Joanna the Mad , was the first queen regnant to reign over both the Crown of Castile and the Crown of Aragon , a union which evolved into modern Spain...

. As the heir to the throne he was styled Prince of Portugal.

John Manuel was born in 3 June 1537 in Évora
Évora
Évora is a municipality in Portugal. It has total area of with a population of 55,619 inhabitants. It is the seat of the Évora District and capital of the Alentejo region. The municipality is composed of 19 civil parishes, and is located in Évora District....

 and became the heir to the throne of Portugal
Portugal
Portugal , officially the Portuguese Republic is a country situated in southwestern Europe on the Iberian Peninsula. Portugal is the westernmost country of Europe, and is bordered by the Atlantic Ocean to the West and South and by Spain to the North and East. The Atlantic archipelagos of the...

 in 1539. He survived his four older brothers who died in childhood but was a sickly teenager. The successive inter-marriages between the houses of Spain
Spain
Spain , officially the Kingdom of Spain languages]] under the European Charter for Regional or Minority Languages. In each of these, Spain's official name is as follows:;;;;;;), is a country and member state of the European Union located in southwestern Europe on the Iberian Peninsula...

 and Portugal probably had some responsibility for his ill health. In 1552 he married Joan of Spain (princess of Spain), his first cousin, through both paternal and maternal line, daughter of his paternal aunt Isabella of Portugal
Isabella of Portugal
Isabella of Portugal was a Portuguese Princess and Holy Roman Empress, Duchess of Burgundy, and a Queen Regent/Consort of Spain. She was the daughter of Manuel I of Portugal and Maria of Aragon. By her marriage to Charles V, Holy Roman Emperor, Isabella was also Holy Roman Empress and Queen...

 and of his maternal uncle Emperor Charles V
Charles V, Holy Roman Emperor
Charles V was ruler of the Holy Roman Empire from 1519 and, as Charles I, of the Spanish Empire from 1516 until his voluntary retirement and abdication in favor of his younger brother Ferdinand I and his son Philip II in 1556.As...

.

John Manuel died of what the sources refer to as consumption (tuberculosis
Tuberculosis
Tuberculosis, MTB, or TB is a common, and in many cases lethal, infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis. Tuberculosis usually attacks the lungs but can also affect other parts of the body...

) on 2 January 1554, however it is worth mentioning that some historians believe his death occurred as a result of diabetes, a disease he inherited from his maternal grandfather Philip I. Eighteen days later, a posthumous son was born from his marriage: the future King Sebastian I of Portugal.

Ancestry

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