Haplotypes groups	DQA*01:DRB1*1001
Structure (See HLA-DR)
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRA
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRA*0101
Identifiers
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-DRB1
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	DRB1*1001
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-DR10 (DR10) is a HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-DR serotype that recognizes the DRB1*1001 gene product.

Serology

DR10 serotype recognition of the DRB1*1001 allele gene product

DRB1*	DR10	DR1		Sample
allele	%	%	%	size (N)
1001	90	4		894

The serological reaction of DR10 is relatively good.

By allele

DRB1*1001 is associated with ovarian cancer

Ovarian cancer

Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses....

 and invasive squamous cell cervical cancer

Cervical cancer

Cervical cancer is malignant neoplasm of the cervix uteri or cervical area. One of the most common symptoms is abnormal vaginal bleeding, but in some cases there may be no obvious symptoms until the cancer is in its advanced stages...

 (SCC)

Extended linkage

DRB1*1001:DQA1*01:DQB1*05 haplotype: Rheumatoid arthritis The primary involvement appears to be DR10.

Genetic Linkage

	DRA	DRB1	|
Haplotypes	*0101	*1001
	DQA1	DQB1	| DRB1
Haplotypes	*0101	*0501	*1001
	HLA-A	HLA-B	| DRB1
Haplotypes	*0000	*0000	*1001

HLA-DR10 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1

HLA-DQ1

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...

 and DQ5

HLA-DQ5

HLA-DQ4 is a human leukocyte antigen serotype subgroup within HLA-DQ serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1 locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4...

serotypes. One haplotype found in caucasians is the HLA-A1-B37-Cw6-DR10-DQ5.