HLA-DQ5
Encyclopedia
HLA-DQ4 is a human leukocyte antigen
serotype
subgroup within HLA-DQ
(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1
locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1
alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1
encoded by the DQA1*01 allele group.
The efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above. Since
DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning
that DQ1 is corecognized with DQ5 and DQ6. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ5 recognition is relatively low and error prone.
While DQ5 recognizes DQB1*05 alleles more efficiently than DQ1, the serotyping is rather poor method of typing for transplantation or disease association prediction or study.
in Polish children, and adrenocortical failure (Addison's disease
).
A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely, AIDP type of Guillain Barré syndrome, and irritable bowel disease but not crohn's disease in the same (Jewish) population. Other studies show DQ5 is associated with extrachromosomal manifestations of Crohn's.
DQ5 appears to be associated with analgesic intolerance.
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...
subgroup within HLA-DQ
HLA-DQ
HLA-DQ is a cell surface receptor type protein found on antigen presenting cells. DQ is an αβ heterodimer of the MHC Class II type. The α and β chains are encoded by HLA-DQA1 and HLA-DQB1, respectively. These two loci are adjacent to each other on chromosome 6p21.3. Both the α-chain and β-chain...
(DQ) serotypes. The serotype is determined by the antibody recognition of β5.x subset of DQ β-chains. The β-chain of DQ is encoded by HLA-DQB1
HLA-DQB1
Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic locus that contains this gene...
locus and DQ5 are encoded by the HLA-DQB1*05 allele group. This group currently contains 4 common alleles, DQB1*0501, *0502, *0503, and *0504. HLA-DQ5 and HLA-DQB1*05 are almost synonymous in meaning. DQ5 β-chains combine with α-chains, encoded by genetically linked HLA-DQA1
HLA-DQA1
Major histocompatibility complex, class II, DQ alpha 1, also known as HLA-DQA1, is a human gene present on short arm of chromosome 6 and also denotes the genetic locus which contains this gene...
alleles, to form the cis-haplotype isoforms. These isoforms, are all HLA-DQ1
HLA-DQ1
HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. Historically it was identified as a DR-like alpha chain called DC1, later, it was among 3 types DQw1 , DQw2 and DQw3. Of these three serotyping specificities only DQw1 recognized DQ alpha chain. The serotype is positive in...
encoded by the DQA1*01 allele group.
Serology
| DQB1* | DQ5 | DQ1 | DQ6 | Sample |
| allele | % | % | % | size (N) |
| 69 | 20 | 2 | 5536 | |
| 48 | 24 | 15 | 919 | |
| 58 | 22 | 4 | 1327 | |
| 59 | 17 | 2 | 48 | |
| Red indicates the level of 'false' reaction in non-DQ5 serotypes | ||||
The efficiency of DQ1 recognition relative to DQ5 and DQ6 is listed above. Since
DQ1 recognizes alpha, the DQ5 and DQ6 recognition are to beta chain. Meaning
that DQ1 is corecognized with DQ5 and DQ6. Efficient recognition of a genotyped allele approaches 100%. Compared to DQ2 serotyping of DQB1*0201 positive individuals (98%), the efficiency of DQ5 recognition is relatively low and error prone.
While DQ5 recognizes DQB1*05 alleles more efficiently than DQ1, the serotyping is rather poor method of typing for transplantation or disease association prediction or study.
By serotype
DQ5 is negatively associated with (protective against) idiopathic nephrotic syndromeNephrotic syndrome
Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak large amounts of protein from the blood into the urine....
in Polish children, and adrenocortical failure (Addison's disease
Addison's disease
Addison’s disease is a rare, chronic endocrine disorder in which the adrenal glands do not produce sufficient steroid hormones...
).
A study on the relationship between HLA-DR, DQ antigen, and intracranial aneurysm in the Han nationality show DQ5 more likely, AIDP type of Guillain Barré syndrome, and irritable bowel disease but not crohn's disease in the same (Jewish) population. Other studies show DQ5 is associated with extrachromosomal manifestations of Crohn's.
DQ5 appears to be associated with analgesic intolerance.