Alleles	B*5301 B*5302
Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... )
Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world...	HLA-B
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	B*5301
EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...	B*5302
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-B53 (B53) is an HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B

HLA-B

HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. The serotype identifies the more common HLA-B*53 gene products. The B53 sequence is identical to B35

HLA-B35

HLA-B35 is an HLA-B serotype. The serotype identifies the more common HLA-B*35 gene products.B35 is one of the largest B serotype groups, it currently has 97 known nucleotide variants and 86 polypeptide isoforms. -Serotype:...

 but short sequence specifies a Bw4 rather than a Bw6 motif (as found in B35), indicating B53 is a recent product of gene conversion. This suggests an origin for HLA-B53 involving a gene conversion of HLA-B35 by an allele containing this Bw4 sequence. (For terminology help see: HLA-serotype tutorial)

Serotype

B53 and B35 serotype recognition of Some HLA B*35 allele-group gene products

B*53	B53	B35	Sample
allele	%	%	size (N)
5301	86	5	3054
5302	80	20	5

B*5301 allele frequencies

HLA B*7801 frequencies

		freq
ref.	Population	(%)
	Akan Adiopodoume (Ivory Coast)	22.7
	Rimaibe (Burkina Faso Burkina Faso Burkina Faso – also known by its short-form name Burkina – is a landlocked country in west Africa. It is surrounded by six countries: Mali to the north, Niger to the east, Benin to the southeast, Togo and Ghana to the south, and Côte d'Ivoire to the southwest.Its size is with an estimated... )	22.3
	Mossi (Burkina Faso)	20.8
	Bandiagara Bandiagara Bandiagara is a city in the Dogon region of Mali in Africa. The name translates roughly to "large eating bowl"—referring to the communal bowl meals are served in....  (Mali Mali Mali , officially the Republic of Mali , is a landlocked country in Western Africa. Mali borders Algeria on the north, Niger on the east, Burkina Faso and the Côte d'Ivoire on the south, Guinea on the south-west, and Senegal and Mauritania on the west. Its size is just over 1,240,000 km² with... )	15.9
	Sawa Sawa Sawa may refer to:*The Sawa peoples of CameroonLocations*Sawa, Nepal*The Sawa Defence Training Centre of Eritrea*Sawa, Lesser Poland Voivodeship Arts*SAWA, Japanese techno-pop singer*Devon Sawa, Canadian actor...  (Cameroon Cameroon Cameroon, officially the Republic of Cameroon , is a country in west Central Africa. It is bordered by Nigeria to the west; Chad to the northeast; the Central African Republic to the east; and Equatorial Guinea, Gabon, and the Republic of the Congo to the south. Cameroon's coastline lies on the... )	11.5
	Lusaka Lusaka Lusaka is the capital and largest city of Zambia. It is located in the southern part of the central plateau, at an elevation of about 1,300 metres . It has a population of about 1.7 million . It is a commercial centre as well as the centre of government, and the four main highways of Zambia head...  (Zambia Zambia Zambia , officially the Republic of Zambia, is a landlocked country in Southern Africa. The neighbouring countries are the Democratic Republic of the Congo to the north, Tanzania to the north-east, Malawi to the east, Mozambique, Zimbabwe, Botswana and Namibia to the south, and Angola to the west.... )	10.2
	Baka Pygmy (Cameroon)	10.0
	Guinea Bissau	10.0
	Harare Shona (Zimbabwe Zimbabwe Zimbabwe is a landlocked country located in the southern part of the African continent, between the Zambezi and Limpopo rivers. It is bordered by South Africa to the south, Botswana to the southwest, Zambia and a tip of Namibia to the northwest and Mozambique to the east. Zimbabwe has three... )	9.3
	Baloch Baloch people The Baloch or Baluch are an ethnic group that belong to the larger Iranian peoples. Baluch people mainly inhabit the Balochistan region and Sistan and Baluchestan Province in the southeast corner of the Iranian plateau in Western Asia....  (Iran Iran Iran , officially the Islamic Republic of Iran , is a country in Southern and Western Asia. The name "Iran" has been in use natively since the Sassanian era and came into use internationally in 1935, before which the country was known to the Western world as Persia... )	9.1
	Kenya	8.7
	Canoncito Navajo (USA)	8.5
	Brahui Brahui people The Brahui or Brohi are ethnic Baloch group of about 2.2 million people with the majority found in Kalat, Baluchistan, Pakistan, but they are also found in smaller numbers in neighboring Afghanistan and Iran. The Brahuis are almost entirely Sunni Muslims.-Origins:The ethnonym "Brahui" is a very...  (Pakistan Pakistan Pakistan , officially the Islamic Republic of Pakistan is a sovereign state in South Asia. It has a coastline along the Arabian Sea and the Gulf of Oman in the south and is bordered by Afghanistan and Iran in the west, India in the east and China in the far northeast. In the north, Tajikistan... )	7.7
	Niokholo Mandenka (Senegal)	5.3
	Croatia (2)	5.0
	Mongolia Khoton Tarialan	4.9
	Pakistan Baloch	4.6
	Casablanca (Morocco)	3.7
	Arratia Basque (Spain)	3.3
	Crete (Greece)	3.2
	Israel Arab Druse	2.5
	Israel Gaza Palestinians	2.4
	Amman (Jordan )	2.4
	Tunis (Tunisia )	2.3
	Tuva (2) (Russia)	2.2
	Oman	2.1
	France South East	1.6
	Saudi Arabia Guraiat and Hail	1.5
	Berber (Morocco)	1.4
	Georgia Svaneti Svans	1.3
	Mongolia Khalkh Ulaanbaatar	1.2
	Spain Catalonia Girona	1.1
	India Andhra Pradesh Golla	1.0
	Mongolia Khalha	1.0

Haplotype frequencies

A*3601 : Cw*0401 : B*5301

		freq
ref.	Population	(%)
	Zimbabwe	3.6
	Zambia Lusaka	2.3
	N. Afr. Negroid	2.1
	Kenya Luo	1.9
	Cameroon Yaounde	1.7
	African American	1.5
	Kenya Nandi	1.3
	American Hispanic	0.2
'
A*6802 : Cw*0401 : B*5301
	Mali Bandihagara	2.7
	African American	1.4
	Kenya Nandi	1.0
	Hispanic American	0.6
	Caucasian American	0.2

Despite its low frequency, the A36-Cw4-B53 haplotype is one of the most common A-Cw-B haplotypes, as it is the 4th most common in African Americans.