Gordon MacPherson
Encyclopedia
Dr George Gordon MacPherson is Reader in Experimental Pathology
, Turnbull Fellow, Tutor in Medicine
, and Senior Tutor at Oriel College, Oxford. He holds a Bachelor's degree (B.M.
), Master's degree (M.A.
) and a doctorate (D.Phil.). His research interests lie in Cell Biology, Pathology
, and Immunology
. Medically qualified, he researches immunology at the Sir William Dunn
School of Pathology
, University of Oxford
.
He is recognized for his "pioneering work" on the modulation of the adaptive immune response
by sub-populations of antigen
-presenting dendritic cells, including a sub-population of dendritic cells which presents self-antigens derived from apoptotic
gastrointestinal
epithelial cells
and helps maintain self-tolerance. This contrasts with the role of other dendritic cells in presenting pathogen
-derived antigens in order to activate specific anti-pathogen T-cell and B-cell responses.
He has also been a member of a British study group determining novel breast cancer
susceptibility loci.
Pathology
Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....
, Turnbull Fellow, Tutor in Medicine
Medicine
Medicine is the science and art of healing. It encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
, and Senior Tutor at Oriel College, Oxford. He holds a Bachelor's degree (B.M.
Bachelor's degree
A bachelor's degree is usually an academic degree awarded for an undergraduate course or major that generally lasts for three or four years, but can range anywhere from two to six years depending on the region of the world...
), Master's degree (M.A.
Master's degree
A master's is an academic degree granted to individuals who have undergone study demonstrating a mastery or high-order overview of a specific field of study or area of professional practice...
) and a doctorate (D.Phil.). His research interests lie in Cell Biology, Pathology
Pathology
Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....
, and Immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
. Medically qualified, he researches immunology at the Sir William Dunn
Sir William Dunn Professor of Biochemistry
The Sir William Dunn Professorship of Biochemistry is the senior professorship in biochemistry at the University of Cambridge. The position was established in 1914 by the trustees of the will of Sir William Dunn, banker, merchant and philanthropist....
School of Pathology
Pathology
Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....
, University of Oxford
University of Oxford
The University of Oxford is a university located in Oxford, United Kingdom. It is the second-oldest surviving university in the world and the oldest in the English-speaking world. Although its exact date of foundation is unclear, there is evidence of teaching as far back as 1096...
.
He is recognized for his "pioneering work" on the modulation of the adaptive immune response
Adaptive immune system
The adaptive immune system is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogenic growth. Thought to have arisen in the first jawed vertebrates, the adaptive or "specific" immune system is activated by the “non-specific” and evolutionarily older innate...
by sub-populations of antigen
Antigen
An antigen is a foreign molecule that, when introduced into the body, triggers the production of an antibody by the immune system. The immune system will then kill or neutralize the antigen that is recognized as a foreign and potentially harmful invader. These invaders can be molecules such as...
-presenting dendritic cells, including a sub-population of dendritic cells which presents self-antigens derived from apoptotic
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
gastrointestinal
Gastrointestinal tract
The human gastrointestinal tract refers to the stomach and intestine, and sometimes to all the structures from the mouth to the anus. ....
epithelial cells
Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue. Epithelial tissues line the cavities and surfaces of structures throughout the body, and also form many glands. Functions of epithelial cells include secretion, selective...
and helps maintain self-tolerance. This contrasts with the role of other dendritic cells in presenting pathogen
Pathogen
A pathogen gignomai "I give birth to") or infectious agent — colloquially, a germ — is a microbe or microorganism such as a virus, bacterium, prion, or fungus that causes disease in its animal or plant host...
-derived antigens in order to activate specific anti-pathogen T-cell and B-cell responses.
He has also been a member of a British study group determining novel breast cancer
Breast cancer
Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...
susceptibility loci.
Publications
His ten most cited publications are:- Huang, F.-P., Platt, N., Wykes, M., Major, J.R., Powell, T.J., Jenkins, C.D., MacPherson, G.G. "A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes" (2000) Journal of Experimental MedicineJournal of Experimental MedicineThe Journal of Experimental Medicine is a peer-reviewed academic journal published by the Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease...
, 191 (3), pp. 435-443. Cited 427 times.
- MacPherson, G.G., Warrell, M.J., White, N.J. "Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. (1985) American Journal of PathologyAmerican Journal of PathologyThe American Journal of Pathology is the official academic journal of the American Society for Investigative Pathology, covering original papers in disease biology, particularly in human disease.-Editors:*1925-1940 - Frank Burr Mallory...
, 119 (3), pp. 385-401. Cited 279 times.
- Damoisequx, J.G.M.C., Dopp, E.A., Calame, W., Chao, D., MacPherson, G.G., Dijkstra, C.D. "Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. (1994) Immunology, 83 (1), pp. 140-147. Cited 250 times.
- Liu, L.M., MacPherson, G.G. "Antigen acquisition by dendritic cells: Intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo." (1993) Journal of Experimental MedicineJournal of Experimental MedicineThe Journal of Experimental Medicine is a peer-reviewed academic journal published by the Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease...
, 177 (5), pp. 1299-1307. Cited 176 times.
- Wykes, M., Pombo, A., Jenkins, C., MacPherson, G.G. "Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response" (1998) Journal of ImmunologyJournal of ImmunologyThe Journal of Immunology is a peer-reviewed academic journal that publishes basic and clinical studies in all aspects of immunology. It was founded by Arthur Fernandez Coca in 1915 . It is the official journal of The American Association of Immunologists and published by The American Association...
, 161 (3), pp. 1313-1319. Cited 146 times.
- MacPherson, G.G., Jenkins, C.D., Stein, M.J., Edwards, C. Endotoxin-mediated dendritic cell release from the intestine: Characterization of released dendritic cells and TNF dependence" (1995) Journal of ImmunologyJournal of ImmunologyThe Journal of Immunology is a peer-reviewed academic journal that publishes basic and clinical studies in all aspects of immunology. It was founded by Arthur Fernandez Coca in 1915 . It is the official journal of The American Association of Immunologists and published by The American Association...
, 154 (3), pp. 1317-1322. Cited 145 times.
- Hume, D.A., Robinson, A.P., MacPherson, G.G., Gordon, S."The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Lagerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs" (1983) Journal of Experimental MedicineJournal of Experimental MedicineThe Journal of Experimental Medicine is a peer-reviewed academic journal published by the Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease...
, 158 (5), pp. 1522-1536. Cited 116 times.
- Pugh, C.W., MacPherson, G.G., Steer, H.W. Characterization of nonlymphoid cells derived from rat peripheral lymph (1983) Journal of Experimental MedicineJournal of Experimental MedicineThe Journal of Experimental Medicine is a peer-reviewed academic journal published by the Rockefeller University Press that publishes research papers and commentaries on the physiological, pathological, and molecular mechanisms that encompass the host response to disease...
, 157 (6), pp. 1758-1779. Cited 99 times.
- Huang, F.-P., Farquhar, C.F., Mabbott, N.A., Bruce, M.E., MacPherson, G.G. Migrating intestinal dendritic cells transport PrPSc from the gut (2002) Journal of General VirologyJournal of General VirologyThe Journal of General Virology is a peer-reviewed academic journal that covers research into viruses affecting animals, plants, insects, bacteria and fungi, including their molecular biology, immunology and interactions with the host. Antiviral compounds are also covered. Established in 1967, it...
, 83 (1), pp. 267-271. Cited 77 times.
- Liu, L., Zhang, M., Jenkins, C., MacPherson, G.G. "Dendritic cell heterogeneity in vivo: Two functionally different dendritic cell populations in rat intestinal lymph can be distinguished by CD4 expression" (1998) Journal of ImmunologyJournal of ImmunologyThe Journal of Immunology is a peer-reviewed academic journal that publishes basic and clinical studies in all aspects of immunology. It was founded by Arthur Fernandez Coca in 1915 . It is the official journal of The American Association of Immunologists and published by The American Association...
, 161 (3), pp. 1146-1155. Cited 72 times.