FADD
Encyclopedia
- This article is about molecular biology. For other uses, see Fadd (disambiguation).
Fas-Associated protein with Death Domain (FADD) is an adaptor molecule that bridges the Fas-receptor, and other death receptors, to caspase-8 through its death domain to form the death-inducing signaling complex
Death-inducing signaling complex
The death-inducing signaling complex or DISC is a multi-protein complex formed by members of the "death receptor" family of apoptosis-inducing cellular receptors. A typical example is FasR, which forms the DISC upon trimerization as a result of its ligand binding. Dogma states that the DISC is...
(DISC) during apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
.
Signalling
Interactions
FADD has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with ABCA1
ABCA1
ATP-binding cassette transporter ABCA1 , also known as the cholesterol efflux regulatory protein is a protein which in humans is encoded by the ABCA1 gene...
, CFLAR
CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called FLICE-like inhibitory protein .-Further reading:...
, PEA15
PEA15
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.PEA15 is a death effector domain -containing protein predominantly expressed in the central nervous system, particularly in astrocytes....
, NACA
NACA (gene)
Nascent-polypeptide-associated complex alpha polypeptide, also known as NACA, is a protein which in humans is encoded by the NACA gene.- Function :...
, Caspase 10
Caspase 10
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.-Interactions:Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B.-External links:*...
, Caspase 8
Caspase 8
Caspase 8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase 3.CASP8 orthologs have been identified in numerous mammals for which complete genome data are available...
, Fas receptor
Fas receptor
The FAS receptor also known as apoptosis antigen 1 , cluster of differentiation 95 or tumor necrosis factor receptor superfamily member 6 is a protein that in humans is encoded by the TNFRSF6 gene....
, Fas ligand
FAS ligand
Fas ligand is a type-II transmembrane protein that belongs to the tumor necrosis factor family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.- Structure :Fas ligand or...
, DAP3
DAP3
28S ribosomal protein S29, mitochondrial is a protein that in humans is encoded by the DAP3 gene.-Interactions:DAP3 has been shown to interact with FADD, TNFRSF10A, Glucocorticoid receptor and Heat shock protein 90kDa alpha , member A1....
, DEDD
DEDD
Death effector domain-containing protein is a protein that in humans is encoded by the DEDD gene.-Interactions:DEDD has been shown to interact with Caspase 8, FADD and CFLAR.-Further reading:...
, TNFRSF1A
TNFRSF1A
Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...
, TRADD
TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.TRADD is an adaptor protein.- Function :...
, TNFRSF10B
TNFRSF10B
Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, is a human gene.As know as; DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5-Interactions:...
and MBD4
MBD4
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.-Interactions:MBD4 has been shown to interact with MLH1 and FADD.-Further reading:...
.