Caspase 8
Encyclopedia
Caspase 8 is a caspase
protein, encoded by the CASP8 gene. It most likely acts upon caspase 3
.
CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds.
with CFLAR
, PEA15
, Caspase 10
, Caspase-9
, Fas receptor
, Fas ligand
, Caspase 7
, NOL3
, BH3 interacting domain death agonist
, DEDD
, TRAF1
, Bcl-2
, RIPK1
, TNFRSF10B
, FADD
, BCAP31
, IFT57
, Caspase 3
, Caspase 2
and Caspase 6
.
Caspase
Caspases, or cysteine-aspartic proteases or cysteine-dependent aspartate-directed proteases are a family of cysteine proteases that play essential roles in apoptosis , necrosis, and inflammation....
protein, encoded by the CASP8 gene. It most likely acts upon caspase 3
Caspase 3
Caspase 3 is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available...
.
CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. Unique orthologs are also present in birds.
Description
Interactions
Caspase 8 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with CFLAR
CFLAR
CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called FLICE-like inhibitory protein .-Further reading:...
, PEA15
PEA15
Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.PEA15 is a death effector domain -containing protein predominantly expressed in the central nervous system, particularly in astrocytes....
, Caspase 10
Caspase 10
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.-Interactions:Caspase 10 has been shown to interact with FADD, CFLAR, Caspase 8, Fas receptor, RYBP, TNFRSF1A and TNFRSF10B.-External links:*...
, Caspase-9
Caspase-9
Caspase-9 is an initiator caspase, encoded by the CASP9 gene.CASP9 orthologs have been identified in all mammals for which complete genome data are available. Unique orthologs are also present in lizards, lissamphibians, and teleosts....
, Fas receptor
Fas receptor
The FAS receptor also known as apoptosis antigen 1 , cluster of differentiation 95 or tumor necrosis factor receptor superfamily member 6 is a protein that in humans is encoded by the TNFRSF6 gene....
, Fas ligand
FAS ligand
Fas ligand is a type-II transmembrane protein that belongs to the tumor necrosis factor family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.- Structure :Fas ligand or...
, Caspase 7
Caspase 7
Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene.CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available...
, NOL3
NOL3
Nucleolar protein 3 is a protein that in humans is encoded by the NOL3 gene.-Interactions:NOL3 has been shown to interact with SFRS9 and Caspase 8.-Further reading:...
, BH3 interacting domain death agonist
BH3 interacting domain death agonist
The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family. Bcl-2 family members share one or more of the four characteristic domains of homology entitled the Bcl-2 homology domains , and can form hetero- or homodimers...
, DEDD
DEDD
Death effector domain-containing protein is a protein that in humans is encoded by the DEDD gene.-Interactions:DEDD has been shown to interact with Caspase 8, FADD and CFLAR.-Further reading:...
, TRAF1
TRAF1
TNF receptor-associated factor 1 is a protein that in humans is encoded by the TRAF1 gene.-Interactions:TRAF1 has been shown to interact with CD30, CFLAR, Baculoviral IAP repeat-containing protein 3, BIRC2, Caspase 8, HIVEP3, TNFAIP3, TRAF2, RANK and TRAF interacting protein.-Further reading:...
, Bcl-2
Bcl-2
Bcl-2 is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range of proteins initially described in chromosomal translocations involving chromosomes 14 and 18 in...
, RIPK1
RIPK1
Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.-Interactions:RIPK1 has been shown to interact with CA11, RIPK3, RNF11, Baculoviral IAP repeat-containing protein 3, CFLAR, BIRC2, Caspase 8, RNF216, TNFRSF1A, Sequestosome 1, TRAF2,...
, TNFRSF10B
TNFRSF10B
Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, is a human gene.As know as; DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5-Interactions:...
, FADD
FADD
Fas-Associated protein with Death Domain is an adaptor molecule that bridges the Fas-receptor, and other death receptors, to caspase-8 through its death domain to form the death-inducing signaling complex during apoptosis. -Signalling:...
, BCAP31
BCAP31
B-cell receptor-associated protein 31 is a protein that in humans is encoded by the BCAP31 gene.-Interactions:BCAP31 has been shown to interact with Caspase 8, VAMP3, BCL2-like 1, Bcl-2 and Amyloid precursor protein.-Further reading:...
, IFT57
IFT57
Intraflagellar transport protein 57 homolog is a protein that in humans is encoded by the IFT57 gene.-Interactions:IFT57 has been shown to interact with Caspase 8.-Further reading:...
, Caspase 3
Caspase 3
Caspase 3 is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene. CASP3 orthologs have been identified in numerous mammals for which complete genome data are available...
, Caspase 2
Caspase 2
Caspase 2 also known as CASP2 is an enzyme that, in humans, is encoded by the CASP2 gene. CASP2 orthologs have been identified in nearly all mammals for which complete genome data are available...
and Caspase 6
Caspase 6
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.CASP6 orthologs have been identified in numerous mammals for which complete genome data are available...
.
Additional Photos
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External links
- The MEROPSMeropsMerops may refer to:* Merops , a genus of bee-eaters.* MEROPS, an on-line database for peptidases.It may also refer to several figures from Greek mythology:* King of Ethiopia, husband of Clymene, who lay with Helios and bore Phaethon...
online database for peptidases and their inhibitors: C14.009 - Apoptosis & Caspase 8 - The Proteolysis MapThe Proteolysis MapThe Proteolysis MAP is an integrated web resource focused on proteases.-Rationale:PMAP is to aid the protease researchers in reasoning about proteolytic networks and metabolic pathways.-History and funding:...
-animation - caspase-8