Dinoprostone
Encyclopedia
The naturally occurring prostaglandin
E2 (PGE2) is known in medicine
as dinoprostone. It has important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever
.
It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.), Propess (by Ferring Pharmaceuticals
) and Glandin (by Nabiqasim Pharmaceuticals Pakistan) as a vagina
l suppository
, to prepare the cervix
for labour; it is used to induce labour.
Like other prostaglandins, dinoprostone can be used as an abortifacient
. It is a direct vasodilator, relaxing smooth muscles, and it inhibits the release of noradrenaline from sympathetic nerve terminals. It does not inhibit platelet aggregation, where PGI2
does.
It works by binding and activating the prostaglandin E2 receptor
.
It was discovered by Bunting, Gryglewski, Moncada and Vane in 1976.
Precautions : uterine scar tissues; asthma; low blood pressure; heart disease; adrenal problems; anemia; diabetes; glaucoma; icterus; multiparity (5 pregnancies); heart, lung or liver disease.
Prostaglandin
A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5-carbon ring....
E2 (PGE2) is known in medicine
Medicine
Medicine is the science and art of healing. It encompasses a variety of health care practices evolved to maintain and restore health by the prevention and treatment of illness....
as dinoprostone. It has important effects in labour (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever
Fever
Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...
.
It is sold under the trade name of Cervidil (by Forest Laboratories, Inc.), Prostin E2 (by Pfizer Inc.), Propess (by Ferring Pharmaceuticals
Ferring Pharmaceuticals
Ferring Pharmaceuticals is a pharmaceutical company that specializes in the development and marketing of drugs for use in human medicine.It was founded by Frederik Paulsen Sr in Malmö, Sweden, in 1950, initially as the Nordiska Hormon Laboratoriet, renamed Ferring in 1954. A ferring in Frisian is a...
) and Glandin (by Nabiqasim Pharmaceuticals Pakistan) as a vagina
Vagina
The vagina is a fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles. Female insects and other invertebrates also have a vagina, which is the terminal part of the...
l suppository
Suppository
A suppository is a drug delivery system that is inserted into the rectum , vagina or urethra , where it dissolves.They are used to deliver both systemically-acting and locally-acting medications....
, to prepare the cervix
Cervix
The cervix is the lower, narrow portion of the uterus where it joins with the top end of the vagina. It is cylindrical or conical in shape and protrudes through the upper anterior vaginal wall...
for labour; it is used to induce labour.
Like other prostaglandins, dinoprostone can be used as an abortifacient
Abortifacient
An abortifacient is a substance that induces abortion. Abortifacients for animals that have mated undesirably are known as mismating shots....
. It is a direct vasodilator, relaxing smooth muscles, and it inhibits the release of noradrenaline from sympathetic nerve terminals. It does not inhibit platelet aggregation, where PGI2
Prostacyclin
Prostacyclin is a member of the family of lipid molecules known as eicosanoids.As a drug, it is also known as "epoprostenol". The terms are sometimes used interchangeably.-History:...
does.
It works by binding and activating the prostaglandin E2 receptor
Prostaglandin E2 receptor
Prostaglandin E2 receptor , also known as EP2, is a prostaglandin receptor for prostaglandin E2. It is encoded by the human gene PTGER2.It may be associated with aspirin-induced asthma.-Mechanism:...
.
It was discovered by Bunting, Gryglewski, Moncada and Vane in 1976.
Precautions : uterine scar tissues; asthma; low blood pressure; heart disease; adrenal problems; anemia; diabetes; glaucoma; icterus; multiparity (5 pregnancies); heart, lung or liver disease.
External links
- Dinoprostone - medlineplus.org
- Cervidil - Forest Laboratories, Inc. (the distributor of Cervidil).
- Prostin E2 - pfizer.com
- Cervidil/Prostin E2 - RxList.com
- What is Cervidil? - birthingnaturally.net.
- Cervidil/Prostin E2 - drugs.com