Councilman body
Encyclopedia
In pathology
, a Councilman body, also known as Councilman hyaline body, is an eosinophilic
globule often found in the liver
of individuals suffering from viral hepatitis, yellow fever
, or other viral syndrome. It represents a hepatocyte
that is undergoing apoptosis
(controlled cell death).
They are also seen in acute viral hepatitis.
was thought to be sufficient evidence for a diagnosis
of yellow fever
. However, they have since been found also to be present in other viral
hemorrhagic fever
s along with acute viral hepatitis, and thus may no longer be considered as diagnostic for yellow fever
.
(1854-1933), who discovered them.
Pathology
Pathology is the precise study and diagnosis of disease. The word pathology is from Ancient Greek , pathos, "feeling, suffering"; and , -logia, "the study of". Pathologization, to pathologize, refers to the process of defining a condition or behavior as pathological, e.g. pathological gambling....
, a Councilman body, also known as Councilman hyaline body, is an eosinophilic
Eosinophilic
Eosinophilic refers to the staining of certain tissues, cells, or organelles after they have been washed with eosin, a dye.Eosin is an acidic dye; thus, the structure being stained is basic....
globule often found in the liver
Liver
The liver is a vital organ present in vertebrates and some other animals. It has a wide range of functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion...
of individuals suffering from viral hepatitis, yellow fever
Yellow fever
Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....
, or other viral syndrome. It represents a hepatocyte
Hepatocyte
A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver's cytoplasmic mass.These cells are involved in:* Protein synthesis* Protein storage* Transformation of carbohydrates...
that is undergoing apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
(controlled cell death).
They are also seen in acute viral hepatitis.
Associated conditions
Until recently the presence of Councilman bodies in a liver biopsyLiver biopsy
Liver biopsy is the biopsy from the liver. It is a medical test that is done to aid diagnosis of liver disease, to assess the severity of known liver disease, and to monitor the progress of treatment.-History:...
was thought to be sufficient evidence for a diagnosis
Diagnosis
Diagnosis is the identification of the nature and cause of anything. Diagnosis is used in many different disciplines with variations in the use of logics, analytics, and experience to determine the cause and effect relationships...
of yellow fever
Yellow fever
Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....
. However, they have since been found also to be present in other viral
Virus
A virus is a small infectious agent that can replicate only inside the living cells of organisms. Viruses infect all types of organisms, from animals and plants to bacteria and archaea...
hemorrhagic fever
Fever
Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...
s along with acute viral hepatitis, and thus may no longer be considered as diagnostic for yellow fever
Yellow fever
Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....
.
Eponym
Councilman bodies are named after American pathologist William Thomas CouncilmanWilliam Thomas Councilman
William Thomas Councilman was an American pathologist, born January 1, 1854, Pikesville, Maryland; died May 26, 1933, York Village, Maine. He is remembered for his contribution in a monograph on amoebic dysentery which described detailed observations of it and its parasite- External links :...
(1854-1933), who discovered them.