Asymmetric catalytic oxidation
Encyclopedia
Asymmetric catalytic oxidation is a technique of oxidizing various substrate
s to give an enantiopure product using a catalyst.
Substrate (chemistry)
In chemistry, a substrate is the chemical species being observed, which reacts with a reagent. This term is highly context-dependent. In particular, in biochemistry, an enzyme substrate is the material upon which an enzyme acts....
s to give an enantiopure product using a catalyst.
Reactions
- Jacobsen epoxidationJacobsen epoxidationThe Jacobsen Epoxidation, sometimes also referred to as Jacobsen-Katsuki Epoxidation is a chemical reaction which allows enantioselective epoxidation of unfunctionalized alkyl- and aryl- substituted olefins. It is complementary to the Sharpless epoxidation...
of alkenes using manganese-salen complex and NaOCl - Sharpless epoxidationSharpless epoxidationThe Sharpless Epoxidation reaction is an enantioselective chemical reaction to prepare 2,3-epoxyalcohols from primary and secondary allylic alcohols....
of allyl alcoholAllyl alcoholAllyl alcohol is an organic compound with the structural formula CH2=CHCH2OH. Like many alcohols,it is a water soluble, colourless liquid, but it is more toxic than typical small alcohols. Allyl alcohol is used as a raw material for the production of glycerol, but is used as a precursor to many...
s using titanium isopropoxide, diethyl tartrateDiethyl tartrateDiethyl tartrate is the ethyl ester of tartaric acid. It is chiral, showing both left- and right-handed forms, as well as a meso stereoisomer.In the Sharpless epoxidation, diethyl tartrate and titanium isopropoxide form a chiral catalyst in situ....
, and t-butyl hydroxyperoxide - Sharpless asymmetric dihydroxylationSharpless asymmetric dihydroxylationSharpless asymmetric dihydroxylation is the chemical reaction of an alkene with osmium tetroxide in the presence of a chiral quinine ligand to form a vicinal diol....
of alkenes using dihydroquinine or dihydroquinidine ligands on an osmiumOsmiumOsmium is a chemical element with the symbol Os and atomic number 76. Osmium is a hard, brittle, blue-gray or blue-blacktransition metal in the platinum family, and is the densest natural element. Osmium is twice as dense as lead. The density of osmium is , slightly greater than that of iridium,...
metal center - Sharpless oxyaminationSharpless oxyaminationThe Sharpless oxyamination is the chemical reaction of alkenes with alkyl imido osmium compounds to form vicinal amino-alcohols. A comprehensive review of this reaction was authored by McLeod et al. in 2002.Vicinal amino-alcohols are important products in organic synthesis and recurring...
- Shi epoxidationShi epoxidationThe Shi epoxidation is a chemical reaction described as an asymmetric epoxidation of olefins with oxone and a fructose-derived catalyst ....
of alkenes using oxone and a fructoseFructoseFructose, or fruit sugar, is a simple monosaccharide found in many plants. It is one of the three dietary monosaccharides, along with glucose and galactose, that are absorbed directly into the bloodstream during digestion. Fructose was discovered by French chemist Augustin-Pierre Dubrunfaut in 1847...
-derived chiral catalyst - Sulfonyloxaziridine enolate oxidation