2C-T-2
Encyclopedia
2C-T-2, or 2,5-dimethoxy
-4-ethyl
thio
phenethylamine
is a psychedelic
and entactogenic
phenethylamine
of the 2C family
. It was first synthesized in 1981 by Alexander Shulgin
. The drug has structural and pharmacodynamic properties similar to the drug 2C-T-7
('Blue Mystic
').
's book PiHKAL
, the dosage range is listed as 12 to 25 mg. According to Erowid
a threshold dose would be 5 mg, a light dose would range from 8–15 mg, a common dose is 15–22 mg and a strong dose would be considered to be 20–40 mg.
, but 2C-T-2 is said to produce more of a "body-load" and other reactions which can be unpleasant, reported effects being reddening of the face and warm flushes. It can also be very nauseating while coming up, some users report a period of restlessness during the come up and feeling cold. There have been no reported deaths from 2C-T-2, unlike 2C-T-7, and the psychedelic effects have been much milder. The onset usually starts after an hour of ingestion and rises for about 2 hours until the user hits the plateau. Insufflated doses reach a peak must faster and have been compared to the effect of ketamine
on the body.
Hallucinations similar to those created by LSD
and other serotonergic psychedelics
are very prominent on typical 2C-T-2 doses. The trip is often described as being similar to LSD due to the serotonergic effects and hallucinations. Some users describe "beautiful" visuals, similar to 2C-T-7
which has coined it's street name "Rosy". In some aspects the effect is similar to other phenethylamines like MDMA (users sometimes have euphoric
rushes); however, unlike MDMA, 2C-T-2 is a strong psychedelic, and its effects can be unpredictable, even for "experienced" users.
2C-T-2 can be just as powerful as LSD and other hallucinogens. Due to the particular body load effect of this substance it is significantly different than most popular hallucinogens though its capability to produce a bad trip
is still present.
There are no known reports of neurotoxicity
. Currently, 2C-T-2 is a research chemical.
It is commonly assumed that the drug meets the same "level" of safety that 2C-B
would because it is within the 2C class of phenethylamines though this is a misconception; all research chemicals are a potential risk to the user. Very little scientific knowledge exists for 2C-T-2, unlike 2C-B
. Effects can last up to 16 hours from dosing.
that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A
serotonin receptor
agonist
in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
family. Other phenethylamine
derivatives substituted with an alkylthio
group at the 4 position such as 2C-T-7
and 4-MTA
are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome
when combined with stimulant
drugs. Most confirmed fatalities involving 2C-T drugs involve their combination with other drugs such as alcohol
, MDMA (ecstasy) or cocaine
. It is also dangerous for a person who takes certain kinds of medication, OTC or prescription, to ingest 2C-T-2. Unfortunately not much is known about contraindications.
.
2C-T-2 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-2 with evidence of intent for human consumption would probably be prosecuted under the Federal Analog Act
because of its structural similarities to 2C-T-7
.
2C-T-2 and all other compounds featured in PiHKAL
are illegal drugs in the United Kingdom
.
It is also a controlled substance in Argentina
as well as 2C-B
and 2C-I
.
Methoxy
In chemistry , methoxy refers to the functional group consisting of a methyl group bound to oxygen. This alkoxy group has the formula O–CH3.The word is used in organic nomenclature usually to describe an ether...
-4-ethyl
Ethyl group
In chemistry, an ethyl group is an alkyl substituent derived from ethane . It has the formula -C2H5 and is very often abbreviated -Et.Ethylation is the formation of a compound by introduction of the ethyl functional group, C2H5....
thio
Thio
The prefix thio-, when applied to a chemical, such as an ion, means that an oxygen atom in the compound has been replaced by a sulfur atom. This meaning is especially valid in organic chemistry. For example, the word ether refers to an oxygen-containing compound having the general chemical...
phenethylamine
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
is a psychedelic
Psychedelic drug
A psychedelic substance is a psychoactive drug whose primary action is to alter cognition and perception. Psychedelics are part of a wider class of psychoactive drugs known as hallucinogens, a class that also includes related substances such as dissociatives and deliriants...
and entactogenic
Empathogen-entactogen
The terms empathogen and entactogen are used to describe a class of psychoactive drugs that produce distinctive emotional and social effects similar to those of MDMA. Putative members of this class include 2C-B, 2C-I, MDMA, MDA, MDEA, MBDB, 2C-T-7, and 2C-T-2, among others...
phenethylamine
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
of the 2C family
2C (psychedelics)
2C is a general name for the family of psychedelic phenethylamines containing methoxy groups on the 2 and 5 positions of the benzene ring. Most of these compounds also carry lipophilic substituents at the 4 position, usually resulting in more potent and more metabolically stable and longer acting...
. It was first synthesized in 1981 by Alexander Shulgin
Alexander Shulgin
Alexander "Sasha" Theodore Shulgin is an American pharmacologist, chemist, artist, and drug developer.Shulgin is credited with the popularization of MDMA, commonly known as ecstasy, in the late 1970s and early 1980s, especially for psychopharmaceutical use and the treatment of depression and...
. The drug has structural and pharmacodynamic properties similar to the drug 2C-T-7
2C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
('Blue Mystic
2C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
').
Dosage
In Alexander ShulginAlexander Shulgin
Alexander "Sasha" Theodore Shulgin is an American pharmacologist, chemist, artist, and drug developer.Shulgin is credited with the popularization of MDMA, commonly known as ecstasy, in the late 1970s and early 1980s, especially for psychopharmaceutical use and the treatment of depression and...
's book PiHKAL
PiHKAL
PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin which was published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens...
, the dosage range is listed as 12 to 25 mg. According to Erowid
Erowid
Erowid, also called The Vaults of Erowid, is an online library of information about psychoactive plants and chemicals and other topics on altered states of consciousness such as meditation and lucid dreaming. It provides information about legal and illegal substances, including their desired and...
a threshold dose would be 5 mg, a light dose would range from 8–15 mg, a common dose is 15–22 mg and a strong dose would be considered to be 20–40 mg.
Effects
Effects are similar to the related 2C-T-72C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
, but 2C-T-2 is said to produce more of a "body-load" and other reactions which can be unpleasant, reported effects being reddening of the face and warm flushes. It can also be very nauseating while coming up, some users report a period of restlessness during the come up and feeling cold. There have been no reported deaths from 2C-T-2, unlike 2C-T-7, and the psychedelic effects have been much milder. The onset usually starts after an hour of ingestion and rises for about 2 hours until the user hits the plateau. Insufflated doses reach a peak must faster and have been compared to the effect of ketamine
Ketamine
Ketamine is a drug used in human and veterinary medicine. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist...
on the body.
Hallucinations similar to those created by LSD
LSD
Lysergic acid diethylamide, abbreviated LSD or LSD-25, also known as lysergide and colloquially as acid, is a semisynthetic psychedelic drug of the ergoline family, well known for its psychological effects which can include altered thinking processes, closed and open eye visuals, synaesthesia, an...
and other serotonergic psychedelics
Serotonergic psychedelic
Serotonergic psychedelics are a class of hallucinogenic drugs with a method of action strongly tied to the serotonin neurotransmitter...
are very prominent on typical 2C-T-2 doses. The trip is often described as being similar to LSD due to the serotonergic effects and hallucinations. Some users describe "beautiful" visuals, similar to 2C-T-7
2C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
which has coined it's street name "Rosy". In some aspects the effect is similar to other phenethylamines like MDMA (users sometimes have euphoric
Euphoria (emotion)
Euphoria is medically recognized as a mental and emotional condition in which a person experiences intense feelings of well-being, elation, happiness, ecstasy, excitement and joy...
rushes); however, unlike MDMA, 2C-T-2 is a strong psychedelic, and its effects can be unpredictable, even for "experienced" users.
2C-T-2 can be just as powerful as LSD and other hallucinogens. Due to the particular body load effect of this substance it is significantly different than most popular hallucinogens though its capability to produce a bad trip
Bad trip
Bad trip is a disturbing experience sometimes associated with use of a psychedelic drug such as LSD, Salvinorin A, DXM, mescaline, psilocybin, DMT and sometimes even other drugs including cannabis, alcohol and MDMA....
is still present.
There are no known reports of neurotoxicity
Neurotoxicity
Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process...
. Currently, 2C-T-2 is a research chemical.
It is commonly assumed that the drug meets the same "level" of safety that 2C-B
2C-B
2C-B or 4-bromo-2,5-dimethoxyphenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred...
would because it is within the 2C class of phenethylamines though this is a misconception; all research chemicals are a potential risk to the user. Very little scientific knowledge exists for 2C-T-2, unlike 2C-B
2C-B
2C-B or 4-bromo-2,5-dimethoxyphenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred...
. Effects can last up to 16 hours from dosing.
Pharmacology
The mechanism of actionMechanism of action
In pharmacology, the term mechanism of action refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect...
that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A
5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor . This is the main excitatory receptor subtype among the GPCRs for serotonin , although 5-HT2A may also have an inhibitory effect on certain areas such...
serotonin receptor
5-HT receptor
The serotonin receptors, also known as 5-hydroxytryptamine receptors or 5-HT receptors, are a group of G protein-coupled receptors and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neurotransmission...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
Dangers
The toxicity of 2C-T-2 is not well documented, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T2C-T
2C-T is a psychedelic and hallucinogenic drug of the 2C family. It is used by some as an entheogen. It has structural and pharmacodynamic properties similar to the drugs mescaline and 2C-T-2....
family. Other phenethylamine
Phenethylamine
Phenylethylamine or phenethylamine is a natural monoamine alkaloid, trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Studies suggest that phenylethylamine functions as a neuromodulator or neurotransmitter in the...
derivatives substituted with an alkylthio
Thio
The prefix thio-, when applied to a chemical, such as an ion, means that an oxygen atom in the compound has been replaced by a sulfur atom. This meaning is especially valid in organic chemistry. For example, the word ether refers to an oxygen-containing compound having the general chemical...
group at the 4 position such as 2C-T-7
2C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
and 4-MTA
4-MTA
4-Methylthioamphetamine is an illicit drug and research chemical developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic highly selective serotonin releasing agent in animals...
are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome
Serotonin syndrome
Serotonin syndrome is a potentially life-threatening adverse drug reaction that may occur following therapeutic drug use, inadvertent interactions between drugs, overdose of particular drugs, or the recreational use of certain drugs...
when combined with stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
drugs. Most confirmed fatalities involving 2C-T drugs involve their combination with other drugs such as alcohol
Alcohol
In chemistry, an alcohol is an organic compound in which the hydroxy functional group is bound to a carbon atom. In particular, this carbon center should be saturated, having single bonds to three other atoms....
, MDMA (ecstasy) or cocaine
Cocaine
Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is a stimulant of the central nervous system, an appetite suppressant, and a topical anesthetic...
. It is also dangerous for a person who takes certain kinds of medication, OTC or prescription, to ingest 2C-T-2. Unfortunately not much is known about contraindications.
Law
The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium LawOpium Law
The Opium Law is the section of the Dutch law which covers nearly all psychotropic drugs. All non-psychotropic, but prescription-only drugs are covered by the Medicine Act.- Origin and history :...
.
2C-T-2 is unscheduled and uncontrolled in the United States, but possession and sales of 2C-T-2 with evidence of intent for human consumption would probably be prosecuted under the Federal Analog Act
Federal Analog Act
The Federal Analog Act, , is a controversial section of the United States Controlled Substances Act which allowed any chemical "substantially similar" to a controlled substance listed in Schedule I or II to be treated as if it were also listed in those schedules, but only if intended for human...
because of its structural similarities to 2C-T-7
2C-T-7
2C-T-7 is a psychedelic phenethylamine of the 2C family. In his book PiHKAL: A Chemical Love Story, Alexander Shulgin lists the dosage range as 10 to 30 mg. 2C-T-7 is generally taken orally, and produces psychedelic and entactogenic effects that last 8 to 15 hours...
.
2C-T-2 and all other compounds featured in PiHKAL
PiHKAL
PiHKAL: A Chemical Love Story is a book by Dr. Alexander Shulgin and Ann Shulgin which was published in 1991. The subject of the work is psychoactive phenethylamine chemical derivatives, notably those that act as psychedelics and/or empathogen-entactogens...
are illegal drugs in the United Kingdom
United Kingdom
The United Kingdom of Great Britain and Northern IrelandIn the United Kingdom and Dependencies, other languages have been officially recognised as legitimate autochthonous languages under the European Charter for Regional or Minority Languages...
.
It is also a controlled substance in Argentina
Argentina
Argentina , officially the Argentine Republic , is the second largest country in South America by land area, after Brazil. It is constituted as a federation of 23 provinces and an autonomous city, Buenos Aires...
as well as 2C-B
2C-B
2C-B or 4-bromo-2,5-dimethoxyphenethylamine is a psychedelic drug of the 2C family. It was first synthesized by Alexander Shulgin in 1974. In Shulgin's book PiHKAL, the dosage range is listed as 16–24 mg. 2C-B is sold as a white powder sometimes pressed in tablets or gel caps and is referred...
and 2C-I
2C-I
2C-I or 2,5-dimethoxy-4-iodophenethylamine is a psychedelic phenethylamine of the 2C family. It was first synthesized by Alexander Shulgin. It was described in Shulgin’s book PiHKAL: A Chemical Love Story. The drug is used recreationally for its psychedelic and entactogenic effects...
.