1348    Charles University is founded in Prague.

1348    Charles University in Prague (Universitas Carolina/Univerzita Karlova) is established as the first university in Central Europe.

1357    Emperor Charles IV assists in laying the foundation stone of Charles Bridge in Prague.

1419    First Defenestration of Prague: a crowd of radical Hussites kill seven members of the Prague city council.

1620    The Battle of White Mountain takes place near Prague, ending in a decisive Catholic victory in only two hours.

1621    Execution of 27 Czech noblemen on the Old Town Square in Prague as a consequence of the Battle of White Mountain.

1631    A Saxon army takes over Prague.

1787    Mozart's opera ''Don Giovanni'' receives its first performance in Prague.

1848    The Slavic congress in Prague begins.

1905    František Pavlík is killed in a demonstration in Prague, inspiring Leoš Janáček to the piano composition 1. X. 1905.

1942    World War II: In Operation Anthropoid, Reinhard Heydrich is assassinated in Prague.

1969    Czech student Jan Palach commits suicide by self-immolation in Prague, in protest against the Soviets' crushing of the Prague Spring the year before.

1969    Student Jan Palach dies after setting himself on fire 3 days earlier in Prague's Wenceslas Square to protest the invasion of Czechoslovakia by the Soviet Union in 1968. His funeral turned into another major protest.

1989    Cold War: Velvet Revolution begins: In Czechoslovakia, a student demonstration in Prague is quelled by riot police. This sparks an uprising aimed at overthrowing the communist government (it succeeds on December 29).

1989    Velvet Revolution: The number of protesters assembled in Prague, Czechoslovakia swells from 200,000 the day before to an estimated half-million.

1991    The Warsaw Pact is officially dissolved at a meeting in Prague.

2000    Anti-globalization protests in Prague (some 20,000 protesters) turn violent during the IMF and World Bank summits.