362 A mysterious fire destroys the temple of Apollo at Daphne outside Antioch.
363 Roman Emperor Julian moves from Antioch with an army of 90,000 to attack the Sassanid Empire, in a campaign which would bring about his own death.
526 An earthquake kills about 300,000 people in Syria and Antiochia.
526 A devastating earthquake strikes Antioch, Turkey, killing 250,000.
969 Byzantine troops occupy Antioch Syria
1098 First Crusade: Antioch falls to the crusaders after an eight-month siege.