Yangonin
Encyclopedia
Yangonin is one of the six major kavalactone
s found in the kava
plant.
Yangonin displays marked in vitro toxicity on human hepatocyte
s with approximately 40% reduction in viability based on an ethidium bromide
assay. The predominant mode of cell death turned out to be apoptosis
rather than necrosis
. No significant changes were observed in glutathione
levels.
Kavalactone
Kavalactones are a class of lactone compounds found in the kava shrub.-Compounds:At least 18 different kavalactones have been identified to date, with methysticin being the first identified.Analogues, such as ethysticin, have also been isolated....
s found in the kava
Kava
Kava or kava-kava is a crop of the western Pacific....
plant.
Yangonin displays marked in vitro toxicity on human hepatocyte
Hepatocyte
A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver's cytoplasmic mass.These cells are involved in:* Protein synthesis* Protein storage* Transformation of carbohydrates...
s with approximately 40% reduction in viability based on an ethidium bromide
Ethidium bromide
Ethidium bromide is an intercalating agent commonly used as a fluorescent tag in molecular biology laboratories for techniques such as agarose gel electrophoresis. It is commonly abbreviated as "EtBr", which is also an abbreviation for bromoethane...
assay. The predominant mode of cell death turned out to be apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
rather than necrosis
Necrosis
Necrosis is the premature death of cells in living tissue. Necrosis is caused by factors external to the cell or tissue, such as infection, toxins, or trauma. This is in contrast to apoptosis, which is a naturally occurring cause of cellular death...
. No significant changes were observed in glutathione
Glutathione
Glutathione is a tripeptide that contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side-chain...
levels.