Thyroid hormone receptor alpha
Encyclopedia
Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor
protein that in humans is encoded by the THRA gene.
. It is one of the several receptors
for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout
studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced
transcript variants encoding distinct isoforms
have been reported.
with:
Nuclear receptor
In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules...
protein that in humans is encoded by the THRA gene.
Function
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronineTriiodothyronine
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate....
. It is one of the several receptors
Thyroid hormone receptor
The thyroid hormone receptor is a type of nuclear receptor that is activated by binding thyroid hormone.-Function:Amongst the most important functions of thyroid hormone receptors are regulation of metabolism and heart rate...
for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout
Gene knockout
A gene knockout is a genetic technique in which one of an organism's genes is made inoperative . Also known as knockout organisms or simply knockouts, they are used in learning about a gene that has been sequenced, but which has an unknown or incompletely known function...
studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced
Alternative splicing
Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene are reconnected in multiple ways during RNA splicing...
transcript variants encoding distinct isoforms
Protein isoform
A protein isoform is any of several different forms of the same protein. Different forms of a protein may be produced from related genes, or may arise from the same gene by alternative splicing. A large number of isoforms are caused by single-nucleotide polymorphisms or SNPs, small genetic...
have been reported.
Interactions
THR1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with:
- COPS2COPS2COP9 signalosome complex subunit 2 is a protein that in humans is encoded by the COPS2 gene.-Interactions:COPS2 has been shown to interact with IRF8, NIF3L1, Thyroid hormone receptor alpha and DAX1.-Further reading:...
, - EP300EP300E1A binding protein p300 also known as EP300 or p300 is a protein that, in humans, is encoded by the EP300 gene. This protein regulates the activity of many genes in tissues throughout the body...
, - ITGB3BPITGB3BPCentromere protein R is a protein that in humans is encoded by the ITGB3BP gene.-Interactions:ITGB3BP has been shown to interact with Retinoid X receptor gamma, Cyclin A2, NFKB1, Retinoid X receptor alpha, Thyroid hormone receptor alpha and CD61....
, - MED1MED1Mediator of RNA polymerase II transcription subunit 1 is a protein that in humans is encoded by the MED1 gene.- Function :The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with...
, - MED6MED6Mediator of RNA polymerase II transcription subunit 6 is an enzyme that in humans is encoded by the MED6 gene.-Interactions:MED6 has been shown to interact with Thyroid hormone receptor alpha, Estrogen receptor alpha, MED21 and Cyclin-dependent kinase 8.-Further reading:...
, - MED12MED12Mediator of RNA polymerase II transcription, subunit 12 homolog , also known as MED12, is a human gene found on the X chromosome...
, - MED16MED16Mediator of RNA polymerase II transcription subunit 16 is an enzyme that in humans is encoded by the MED16 gene.-Interactions:MED16 has been shown to interact with Thyroid hormone receptor alpha, Estrogen receptor alpha and Cyclin-dependent kinase 8....
, - MEF2AMyocyte-specific enhancer factor 2AMyocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26...
, - NCOA6NCOA6Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.-Interactions:NCOA6 has been shown to interact with Ku70, RBBP5, E2F1, Retinoblastoma protein, CREB-binding protein, Activating transcription factor 2, HSF1, HBXIP, TGS1, TUBB, TUBA4A, Thyroid hormone receptor...
, - TRIP11TRIP11Thyroid receptor-interacting protein 11 is a protein that in humans is encoded by the TRIP11 gene.-Interactions:TRIP11 has been shown to interact with Retinoblastoma protein and Thyroid hormone receptor alpha.-Further reading:...
, and - UBCUbiquitin CUbiquitin is a protein that in humans is encoded by the UBC gene.-Interactions:Ubiquitin C has been shown to interact with SCNN1A, SCNN1G, Parkin , P70-S6 Kinase 1, TRAF6, HDAC3, SFPQ, S100A10, Mothers against decapentaplegic homolog 3, NOTCH1, HIF1A, Epidermal growth factor receptor, E2F1,...
.