Taurocholic acid
Encyclopedia
Taurocholic acid, known also as cholaic acid, cholyltaurine, or acidum cholatauricum, is a deliquescent yellowish crystalline bile acid
involved in the emulsification of fat
s. It occurs as a sodium salt
in the bile
of mammal
s. It is a conjugate
of cholic acid
with taurine. In medical use, it is administered as a cholagogue
and choleretic
.
Hydrolysis
of taurocholic acid yields taurine.
For commercial use, taurocholic acid is manufactured from cattle
bile, a byproduct of the meat-processing industry.
This acid is also one of the many molecules in the body that has cholesterol
as its precursor.
Bile acid
Bile acids are steroid acids found predominantly in the bile of mammals. Bile salts are bile acids compounded with a cation, usually sodium. In humans, the salts of taurocholic acid and glycocholic acid represent approximately eighty percent of all bile salts. The two major bile acids are cholic...
involved in the emulsification of fat
Fat
Fats consist of a wide group of compounds that are generally soluble in organic solvents and generally insoluble in water. Chemically, fats are triglycerides, triesters of glycerol and any of several fatty acids. Fats may be either solid or liquid at room temperature, depending on their structure...
s. It occurs as a sodium salt
Salt
In chemistry, salts are ionic compounds that result from the neutralization reaction of an acid and a base. They are composed of cations and anions so that the product is electrically neutral...
in the bile
Bile
Bile or gall is a bitter-tasting, dark green to yellowish brown fluid, produced by the liver of most vertebrates, that aids the process of digestion of lipids in the small intestine. In many species, bile is stored in the gallbladder and upon eating is discharged into the duodenum...
of mammal
Mammal
Mammals are members of a class of air-breathing vertebrate animals characterised by the possession of endothermy, hair, three middle ear bones, and mammary glands functional in mothers with young...
s. It is a conjugate
Conjugated system
In chemistry, a conjugated system is a system of connected p-orbitals with delocalized electrons in compounds with alternating single and multiple bonds, which in general may lower the overall energy of the molecule and increase stability. Lone pairs, radicals or carbenium ions may be part of the...
of cholic acid
Cholic acid
Cholic acid is a bile acid, a white crystalline substance insoluble in water , with a melting point of 200-201 °C. Salts of cholic acid are called cholates. Cholic acid, along with chenodeoxycholic acid, is one of two major bile acids produced by the liver where it is synthesized from cholesterol...
with taurine. In medical use, it is administered as a cholagogue
Cholagogue
A cholagogue is a medicinal agent which promotes the discharge of bile from the system, purging it downward.In Patrick O'Brian's book "The Post Captain," which is set in the Napoleonic era, Stephen Maturin, one of the book's main characters sits in the snug of the Rose and Crown in Deal and drinks...
and choleretic
Choleretic
Choleretics are substances that increase the volume of secretion of bile from the liver as well as the amount of solids secreted....
.
Hydrolysis
Hydrolysis
Hydrolysis is a chemical reaction during which molecules of water are split into hydrogen cations and hydroxide anions in the process of a chemical mechanism. It is the type of reaction that is used to break down certain polymers, especially those made by condensation polymerization...
of taurocholic acid yields taurine.
For commercial use, taurocholic acid is manufactured from cattle
Cattle
Cattle are the most common type of large domesticated ungulates. They are a prominent modern member of the subfamily Bovinae, are the most widespread species of the genus Bos, and are most commonly classified collectively as Bos primigenius...
bile, a byproduct of the meat-processing industry.
This acid is also one of the many molecules in the body that has cholesterol
Cholesterol
Cholesterol is a complex isoprenoid. Specifically, it is a waxy steroid of fat that is produced in the liver or intestines. It is used to produce hormones and cell membranes and is transported in the blood plasma of all mammals. It is an essential structural component of mammalian cell membranes...
as its precursor.