Taksta
Encyclopedia
Taksta is a front-loaded oral dosing regimen of sodium fusidate under development in the U.S. as an antibiotic
for gram-positive
infections including drug-resistant strains such as methicillin-resistant Staphylococcus aureus
(MRSA).
s (being compared with Linezolid
).
Sep 2010: Taksta demonstrated comparable clinical success rates compared to linezolid in a Phase 2 trial in the U.S. for acute bacterial skin and skin structure infections.
Jun 2011: Taksta may be effective in the treatment of chronic prosthetic joint infections and osteomyelitis.
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
for gram-positive
Gram-positive
Gram-positive bacteria are those that are stained dark blue or violet by Gram staining. This is in contrast to Gram-negative bacteria, which cannot retain the crystal violet stain, instead taking up the counterstain and appearing red or pink...
infections including drug-resistant strains such as methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus
Methicillin-resistant Staphylococcus aureus is a bacterium responsible for several difficult-to-treat infections in humans. It is also called multidrug-resistant Staphylococcus aureus and oxacillin-resistant Staphylococcus aureus...
(MRSA).
Clinical trials
Jan 2010: Taksta has completed enrollment in a Phase 2 trial (due to run until March 2010) and is preparing for Phase 3 studies in the U.S. for acute bacterial skin structure infectionSkin and skin structure infection
A skin and skin structure infection is a bacterial infection of skin and associated tissues. It often requires treatment by antibiotics.It is/was divided into two types, complicated skin and skin structure infection and...
s (being compared with Linezolid
Linezolid
Linezolid is a synthetic antibiotic used for the treatment of serious infections caused by Gram-positive bacteria that are resistant to several other antibiotics...
).
Sep 2010: Taksta demonstrated comparable clinical success rates compared to linezolid in a Phase 2 trial in the U.S. for acute bacterial skin and skin structure infections.
Jun 2011: Taksta may be effective in the treatment of chronic prosthetic joint infections and osteomyelitis.