Sultone
Encyclopedia
In organic chemistry, sultones are cyclic sulfonate esters of hydroxy sulfonic acid
s that exist mainly as four-, seven-, and sometimes five-membered rings. They are often short-lived intermediates, used as strong alkylating agents to introduce a negatively charged sulfonate
group.
In the presence of water, they slowly hydrolyze to their respective corrosive hydroxy sulfonic acids. Sultones decompose when heated to produce toxic, foul smelling, sulfur dioxide
fumes.
Sultone oxime
s are key intermediates in the synthesis of the anti-convulsant drug zonisamide
.
Sultones are classified as toxic, carcinogenic, mutagenic, and teratogenic.
Sulfonic acid
Sulfonic acid usually refers to a member of the class of organosulfur compounds with the general formula RS2–OH, where R is an alkyl or aryl. The formal part of acid, HS2–OH, are formally derivatives of the "parent" inorganic compound with the formula HSO2.-Preparation:Sulfonic acid is...
s that exist mainly as four-, seven-, and sometimes five-membered rings. They are often short-lived intermediates, used as strong alkylating agents to introduce a negatively charged sulfonate
Sulfonate
A sulfonate is a salt or ester of a sulfonic acid. It contains the functional group R-SO2O-.- Sulfonate salts:Anions with the general formula RSO2O− are called sulfonates. They are the conjugate bases of sulfonic acids with formula RSO2OH. As sulfonic acids tend to be strong acids, the...
group.
In the presence of water, they slowly hydrolyze to their respective corrosive hydroxy sulfonic acids. Sultones decompose when heated to produce toxic, foul smelling, sulfur dioxide
Sulfur dioxide
Sulfur dioxide is the chemical compound with the formula . It is released by volcanoes and in various industrial processes. Since coal and petroleum often contain sulfur compounds, their combustion generates sulfur dioxide unless the sulfur compounds are removed before burning the fuel...
fumes.
Sultone oxime
Oxime
An oxime is a chemical compound belonging to the imines, with the general formula R1R2C=NOH, where R1 is an organic side chain and R2 may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. O-substituted oximes form a closely related family of compounds...
s are key intermediates in the synthesis of the anti-convulsant drug zonisamide
Zonisamide
Zonisamide is a sulfonamide anticonvulsant approved for use as an adjunctive therapy in adults with partial-onset seizures for adults; infantile spasm, mixed seizure types of Lennox-Gastaut syndrome, myoclonic, and generalized tonic clonic seizure.-History:...
.
Sultones are classified as toxic, carcinogenic, mutagenic, and teratogenic.