Phthalylsulfathiazole
Overview
Phthalylsulfathiazole belongs to the group of drugs called sulfonamides
Sulfonamide (medicine)
Sulfonamide or sulphonamide is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group. Some sulfonamides are also devoid of antibacterial activity, e.g., the anticonvulsant sultiame...

. The drug is a broad spectrum antimicrobial that can treat different types of infections including intestinal. The mechanism of action depends is based on competitive antagonism with para-aminobenzoic acid and inhibition of dihydropteroate synthetase
Dihydropteroate synthetase inhibitor
A dihydropteroate synthetase inhibitor is a drug that inhibits the action of dihydropteroate synthetase. Most are sulfonamides.In bacteria, antibacterial sulfonamides act as competitive inhibitors of the enzyme dihydropteroate synthetase, DHPS. DHPS catalyses the conversion of PABA to...

 activity, that in turn leads to impaired synthesis of dihydrofolic acid
Dihydrofolic acid
Dihydrofolic acid is a folic acid derivative acted upon by dihydrofolate reductase to produce tetrahydrofolic acid. Since tetrahydrofolate is needed to make both purines and pyrimidines, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis. Dihydrofolic acid is...

 and as a result its active metabolite that is necessary for the synthesis of purine
Purine
A purine is a heterocyclic aromatic organic compound, consisting of a pyrimidine ring fused to an imidazole ring. Purines, including substituted purines and their tautomers, are the most widely distributed kind of nitrogen-containing heterocycle in nature....

 and pyrimidine
Pyrimidine
Pyrimidine is a heterocyclic aromatic organic compound similar to benzene and pyridine, containing two nitrogen atoms at positions 1 and 3 of the six-member ring...

.

The drug is indicated in treatment of dysentery, colitis, gastroenteritis and intestinal surgery.
Quotations

Do you understand, gentlemen, that all the horror is in just this—that there is no horror!

Aleksandr Kuprin|Aleksandr Kuprin, The Pit, translation by Bernard G. Guerney.

I can enjoy her while she's kind;But when she dances in the wind,And shakes the wings and will not stay,I puff the prostitute away: The little or the much she gave is quietly resign'd: Content with poverty, my soul I arm; And virtue, though in rags, will keep me warm.

John Dryden, Imitation of Horace (1685), "On Fortune", Book III, Ode 29, l. 81 - 87.

[in Kenya]...any woman who is single and has multiple male sex partners is considered to be a prostitute, whether or not money changes hands.

New Internationalist, Issue 252 - February 1994.

[in India] Any sexual intercourse outside socially acceptable unions is likely to be regarded as prostitution.

New Internationalist, Issue 252 - February 1994.

[In Iran] Under mut'a, it is possible to be 'married' for as little as half an hour.

New Internationalist, Issue 252 - February 1994.

Egyptian law states that a man who is caught with a prostitute is not imprisoned; instead, his testimony is used to convict and imprison the prostitute.

New Internationalist, Issue 252 - February 1994.

Prostitutes are the inevitable product of a society that places ultimate importance on money, possessions, and competition.

Jane Fonda, in Thomas Kiernan, Jane: An Intimate Biography of Jane Fonda (1970).

Prostitution is organized rape.

Christine Stark

 
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