Prostaglandin E synthase 2 is an enzyme that in humans is encoded by the PTGES2 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

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The protein encoded by this gene is a membrane-associated prostaglandin E synthase

Prostaglandin E synthase

Prostaglandin E synthase is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E from prostaglandin H2.The synthase generating PGE2 is a membrane-associated protein....

, which catalyzes the conversion of prostaglandin H2

Prostaglandin H2

Prostaglandin H2 is a type of Prostaglandin which is derived from arachidonic acid and is a precursor for many other biologically significant molecules.It is acted upon by:* prostacyclin synthase to create prostacyclin...

 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a interferon-gamma

Interferon-gamma

Interferon-gamma is a dimerized soluble cytokine that is the only member of the type II class of interferons. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs...

gamma-interferon-activated transcription element (GATE).