PIK3R1 - AbsoluteAstronomy.com

Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme

Enzyme

Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

that in humans is encoded by the PIK3R1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

Interactions

PIK3R1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

with EPH receptor A2

EPH receptor A2

EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.-Interactions:EPH receptor A2 has been shown to interact with PIK3R1, Grb2, ACP1 and SHC1.-References:...

, KHDRBS1

KHDRBS1

KH domain-containing, RNA-binding, signal transduction-associated protein 1 is a protein that in humans is encoded by the KHDRBS1 gene.-Further reading:...

, Lymphocyte cytosolic protein 2

Lymphocyte cytosolic protein 2

Lymphocyte cytosolic protein 2 , also known as LCP2 or SLP-76, is a gene that encodes a signal-transducing adaptor protein.-Interactions:...

, Janus kinase 2

Janus kinase 2

Janus kinase 2 is a human protein that has been implicated in signaling by members of the type II cytokine receptor family , the GM-CSF receptor family , the gp130 receptor family , and the single chain receptors...

, GAB2

GAB2

GRB2-associated-binding protein 2 is a protein that in humans is encoded by the GAB2 gene.The protein encoded by this gene, GAB2 is an adaptor protein serving as principal activator of Phosphatidylinositol 3-kinase...

, CD117

CD117

Mast/stem cell growth factor receptor also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117 is a protein that in humans is encoded by the KIT gene...

, BCAR1

BCAR1

Breast cancer anti-estrogen resistance protein 1 is a protein that in humans is encoded by the BCAR1 gene.-External links:* Info with links in the...

, CD28

CD28

CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation. CD28 is the receptor for CD80 and CD86 . When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells...

, SHB

SHB (gene)

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.-Interactions:SHB has been shown to interact with Fibroblast growth factor receptor 1, Src, Linker of activated T cells, Lymphocyte cytosolic protein 2, ZAP-70, EPS8, PIK3R1 and VAV1.-Further reading:...

, EZR, PIK3CD

P110δ

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform also known as phosphoinositide 3-kinase or p110δ is an enzyme that in humans is encoded by the PIK3CD gene....

, GAB1

GAB1

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.-Interactions:GAB1 has been shown to interact with Grb2, PIK3R1, PTPN11, CRKL, PLCG1 and MAP3K3.-Further reading:...

, HRAS

HRAS

GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene. The HRAS gene is located on the short arm of chromosome 11 at position 15.5, from base pair 522,241 to base pair 525,549.- Function :...

, TUBA1B

TUBA1B

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.-Further reading:...

, CD7

CD7

CD7 is a human protein encoded by the gene.-External links:...

, FCGR2A

FCGR2A

Low affinity immunoglobulin gamma Fc region receptor II-a is a protein that in humans is encoded by the FCGR2A gene.-Interactions:FCGR2A has been shown to interact with PIK3R1 and Syk.-Further reading:- External links :...

, Grb2

Grb2

Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene....

, IRS2

IRS2

Insulin receptor substrate 2 is a protein that in humans is encoded by the IRS2 gene.. Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.-Interactions:...

, ADAM12

ADAM12

For the television show, see Adam 12Disintegrin and metalloproteinase domain-containing protein 12 is an enzyme that in humans is encoded by the ADAM12 gene.-Interactions:...

, TYRO3

TYRO3

Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene.-Interactions:TYRO3 has been shown to interact with PIK3R1 and GAS6.-Further reading:...

, VAV1

VAV1

Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.-Interactions:VAV1 has been shown to interact with Ku70, PLCG1, Lymphocyte cytosolic protein 2, Janus kinase 2, SIAH2, S100B, Abl gene, ARHGDIB, SHB, PIK3R1, PRKCQ, Grb2, MAPK1, Syk, Linker of activated T cells, Cbl gene and...

, ERBB3

ERBB3

Receptor tyrosine-protein kinase erbB-3 is an enzyme that in humans is encoded by the ERBB3 gene.It is thought that ERBB3, when activated, becomes a substrate for dimerization and subsequent phosphorylation by ERBB1, ERBB2 and ERBB4....

, Wiskott-Aldrich syndrome protein

Wiskott-Aldrich syndrome protein

The Wiskott–Aldrich Syndrome Protein is a 502-amino acid protein that is expressed in cells of the hematopoietic system. In the inactive state, WASp exists in an auto-inhibited conformation with sequences near its C-terminus binding to a region near its N-terminus...

, LTK

LTK (gene)

Leukocyte receptor tyrosine kinase is an enzyme that in humans is encoded by the LTK gene.-Interactions:LTK has been shown to interact with IRS-1, Shc, and PIK3R1.-Further reading:...

, PTK2

PTK2

PTK2 protein tyrosine kinase 2 , also known as Focal Adhesion Kinase , is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion and spreading processes...

, Interleukin 1 receptor, type I

Interleukin 1 receptor, type I

Interleukin 1 receptor, type I also known as CD121a , is an interleukin receptor. IL1R1 also denotes its human gene.-Interactions:...

, CBLB

CBLB

E3 ubiquitin-protein ligase CBL-B is an enzyme that in humans is encoded by the CBLB gene.-Interactions:CBLB has been shown to interact with Epidermal growth factor receptor, Grb2, PIK3R1, SH3KBP1, CRKL and NEDD4.-Further reading:...

, Erythropoietin receptor

Erythropoietin receptor

The erythropoietin receptor is a protein that in humans is encoded by the EPOR gene. EpoR is a 59 kDa peptide and is a member of the cytokine receptor family. EpoR pre-exists as dimers...

, Linker of activated T cells

Linker of activated T cells

Linker of Activated T cells, also known as LAT, is a protein which in humans is encoded by the LAT gene. Alternative splicing results in multiple transcript variants encoding different isoforms.-Function:...

, Cbl gene

Cbl gene

Cbl is a mammalian gene encoding several proteins including E3 ubiquitin-protein ligase CBL involved in cell signalling and protein ubiquitination...

, IRS1

IRS1

Insulin receptor substrate 1 is a protein that in humans is encoded by the IRS-1 gene.-Function:Insulin receptor substrate 1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 receptors to intracellular pathways PI3K / Akt and Erk MAP kinase...

and CENTG1

CENTG1

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is an enzyme that in humans is encoded by the AGAP2 gene.-Interactions:CENTG1 has been shown to interact with PIK3R1, HOMER1 and EPB41L1.-Further reading:...