P21 activated kinases
Encyclopedia
p21 activated kinases are members of a family of enzyme
s. They serve as targets for the small GTP
binding proteins CDC42
and Rac
and have been implicated in a wide range of biological activities.
Members include:
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
s. They serve as targets for the small GTP
Guanosine triphosphate
Guanosine-5'-triphosphate is a purine nucleoside triphosphate. It can act as a substrate for the synthesis of RNA during the transcription process...
binding proteins CDC42
CDC42
Cell division control protein 42 homolog also known as CDC42 is a protein involved in regulation of the cell cycle. In humans, CDC42 is encoded by the CDC42 gene.- Function :...
and Rac
Rac (GTPase)
Rac is a subfamily of the Rho family of GTPases, small signaling G proteins .The subgroup include:*Rac1*Rac2*Rac3*RhoG...
and have been implicated in a wide range of biological activities.
Members include:
- PAK1PAK1Serine/threonine-protein kinase PAK 1 is an enzyme that in humans is encoded by the PAK1 gene.-Interactions:PAK1 has been shown to interact with C-Raf, NCK1, LIMK1, RAC1, ARHGEF2, BMX, ARPC1B, DYNLL1, Cyclin-dependent kinase 5, PAK1IP1 and CDC42....
, regulating cell motility and morphology - PAK2PAK2Serine/threonine-protein kinase PAK 2 is an enzyme that in humans is encoded by the PAK2 gene.-Interactions:PAK2 has been shown to interact with SH3KBP1, CDC42 and Abl gene.-External links:* Info with links in the...
, possibly playing a role in apoptosis - PAK3PAK3Serine/threonine-protein kinase PAK 3 is an enzyme that in humans is encoded by the PAK3 gene.-External links:* Info with links in the...
, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity - PAK4PAK4Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.-Interactions:PAK4 has been shown to interact with CDC42, Integrin, beta 5 and LIMK1.-External links:* Info with links in the...
, a mediator of filopodia formation
External links
- PAK Info with links in the Cell Migration Gateway