Overgrowth syndrome
Encyclopedia
Overgrowth syndrome is a group of genetic disorders in which there is an abnormal increase in the size of the body or a body part that is often noted at birth
. Examples of overgrowth syndromes include neurofibromatosis
, Sotos syndrome
, Beckwith-Wiedemann syndrome
, Simpson-Golabi-Behmel syndrome
, Weaver syndrome
, Proteus syndrome
, Sturge–Weber syndrome, and fragile X syndrome
. Many of these syndromes increase the risk of cancer
.
Birth
Birth is the act or process of bearing or bringing forth offspring. The offspring is brought forth from the mother. The time of human birth is defined as the time at which the fetus comes out of the mother's womb into the world...
. Examples of overgrowth syndromes include neurofibromatosis
Neurofibromatosis
Neurofibromatosis is a genetically-inherited disorder in which the nerve tissue grows tumors that may be benign or may cause serious damage by compressing nerves and other tissues...
, Sotos syndrome
Sotos syndrome
Sotos syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. The disorder may be accompanied by autism mild mental retardation, delayed motor, cognitive, and social development, hypotonia , and speech impairments...
, Beckwith-Wiedemann syndrome
Beckwith-Wiedemann syndrome
Beckwith–Wiedemann syndrome is an overgrowth disorder usually present at birth characterized by an increased risk of childhood cancer and certain congenital features. Originally, Dr...
, Simpson-Golabi-Behmel syndrome
Simpson-Golabi-Behmel syndrome
Simpson–Golabi–Behmel syndrome , also called Bulldog syndrome, Sara Agers syndrome, Golabi–Rosen syndrome, Simpson dysmorphia syndrome or X-linked dysplasia gigantism syndrome , is a rare inherited congenital disorder with widely variable expression, causing craniofacial and other abnormalities.It...
, Weaver syndrome
Weaver syndrome
Weaver syndrome is a congenital disorder associated with rapid growth beginning in the prenatal period, a characteristic facial appearance and certain skeletal features. It was first described by Weaver in 1974....
, Proteus syndrome
Proteus syndrome
Proteus syndrome, also known as Wiedemann's syndrome , is a congenital disorder that causes skin overgrowth and atypical bone development, often accompanied by tumors over half the body....
, Sturge–Weber syndrome, and fragile X syndrome
Fragile X syndrome
Fragile X syndrome , Martin–Bell syndrome, or Escalante's syndrome , is a genetic syndrome that is the most commonly known single-gene cause of autism and the most common inherited cause of intellectual disability...
. Many of these syndromes increase the risk of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
.
External links
- Overgrowth syndrome entry in the public domain NCI Dictionary of Cancer Terms
- Macrocephalia is the is a condition in which there is an abnormally overgrown brain.