Otto Lubarsch
Encyclopedia
Otto Lubarsch was a German pathologist who was a native of Berlin.
He originally studied philosophy
and natural sciences in Leipzig
and Heidelberg
, and later earned his medical degree in Strasbourg
in 1883. Subsequently he was an assistant to Hugo Kronecker
(1839-1914) at the Institute of Physiology
in Bern, and afterwards an assistant at the pathological institutes of Giessen, Breslau and Zurich
. In 1891 he became first assistant to Albert Thierfelder
(1842-1908) at the pathological institute at the University of Rostock
, where in 1894 he was appointed an associate professor of pathological anatomy and general pathology. In 1905 he became director of the institute of pathology and bacteriology
at Zwickau
, and later served as a professor in Düsseldorf
(from-1907), Kiel
(from-1913), and Berlin
(1917-1929).
In 1888 Lubarsch provided the first detailed description of carcinoid
tumors during autopsies
of two male "patients", however it wouldn't be until 1907 that the term karzinoid was applied by Siegfried Oberndorfer
(1876-1944). Lubarsch also discovered tiny crystals in the epithelial cells of the testis that resemble sperm
crystals. These structures are now known as Lubarsch' crystals.
With Friedrich Henke (1868-1943), he was editor of the Henke-Lubarsch Handbuch der Speziellen Pathologischen Anatomie und Histologie, which was a massive reference book containing information germane to pathology. It was founded in 1924, and produced over a forty year span. After World War II, it was continued and edited by Robert Rössle
(1876-1956). Also with veterinarian
Robert von Ostertag
(1864-1940) he collaborated on the journal Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie der Menschen und der Tiere.
He originally studied philosophy
Philosophy
Philosophy is the study of general and fundamental problems, such as those connected with existence, knowledge, values, reason, mind, and language. Philosophy is distinguished from other ways of addressing such problems by its critical, generally systematic approach and its reliance on rational...
and natural sciences in Leipzig
Leipzig
Leipzig Leipzig has always been a trade city, situated during the time of the Holy Roman Empire at the intersection of the Via Regia and Via Imperii, two important trade routes. At one time, Leipzig was one of the major European centres of learning and culture in fields such as music and publishing...
and Heidelberg
Heidelberg
-Early history:Between 600,000 and 200,000 years ago, "Heidelberg Man" died at nearby Mauer. His jaw bone was discovered in 1907; with scientific dating, his remains were determined to be the earliest evidence of human life in Europe. In the 5th century BC, a Celtic fortress of refuge and place of...
, and later earned his medical degree in Strasbourg
Strasbourg
Strasbourg is the capital and principal city of the Alsace region in eastern France and is the official seat of the European Parliament. Located close to the border with Germany, it is the capital of the Bas-Rhin département. The city and the region of Alsace are historically German-speaking,...
in 1883. Subsequently he was an assistant to Hugo Kronecker
Hugo Kronecker
Karl Hugo Kronecker was a German physiologist from Liegnitz, Prussian Silesia. He was the brother of Leopold Kronecker....
(1839-1914) at the Institute of Physiology
Physiology
Physiology is the science of the function of living systems. This includes how organisms, organ systems, organs, cells, and bio-molecules carry out the chemical or physical functions that exist in a living system. The highest honor awarded in physiology is the Nobel Prize in Physiology or...
in Bern, and afterwards an assistant at the pathological institutes of Giessen, Breslau and Zurich
Zürich
Zurich is the largest city in Switzerland and the capital of the canton of Zurich. It is located in central Switzerland at the northwestern tip of Lake Zurich...
. In 1891 he became first assistant to Albert Thierfelder
Albert Thierfelder
Ferdinand Albert Thierfelder was a German pathologist born in Meissen. He was the son of Stadtphysikus Johann Gottlieb Thierfelder , and was a younger brother to internist Theodor Thierfelder ....
(1842-1908) at the pathological institute at the University of Rostock
University of Rostock
The University of Rostock is the university of the city Rostock, in the German state of Mecklenburg-Vorpommern.Founded in 1419, it is the oldest and largest university in continental northern Europe and the Baltic Sea area...
, where in 1894 he was appointed an associate professor of pathological anatomy and general pathology. In 1905 he became director of the institute of pathology and bacteriology
Bacteriology
Bacteriology is the study of bacteria. This subdivision of microbiology involves the identification, classification, and characterization of bacterial species...
at Zwickau
Zwickau
Zwickau in Germany, former seat of the government of the south-western region of the Free State of Saxony, belongs to an industrial and economical core region. Nowadays it is the capital city of the district of Zwickau...
, and later served as a professor in Düsseldorf
Düsseldorf
Düsseldorf is the capital city of the German state of North Rhine-Westphalia and centre of the Rhine-Ruhr metropolitan region.Düsseldorf is an important international business and financial centre and renowned for its fashion and trade fairs. Located centrally within the European Megalopolis, the...
(from-1907), Kiel
University of Kiel
The University of Kiel is a university in the city of Kiel, Germany. It was founded in 1665 as the Academia Holsatorum Chiloniensis by Christian Albert, Duke of Holstein-Gottorp and has approximately 23,000 students today...
(from-1913), and Berlin
Berlin
Berlin is the capital city of Germany and is one of the 16 states of Germany. With a population of 3.45 million people, Berlin is Germany's largest city. It is the second most populous city proper and the seventh most populous urban area in the European Union...
(1917-1929).
In 1888 Lubarsch provided the first detailed description of carcinoid
Carcinoid
Carcinoid is a slow-growing type of neuroendocrine tumor, originating in the cells of the neuroendocrine system.In 2000, the World Health Organization redefined "carcinoid", but this new definition has not been accepted by all practitioners. This has led to some complexity in distinguishing...
tumors during autopsies
Autopsy
An autopsy—also known as a post-mortem examination, necropsy , autopsia cadaverum, or obduction—is a highly specialized surgical procedure that consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present...
of two male "patients", however it wouldn't be until 1907 that the term karzinoid was applied by Siegfried Oberndorfer
Siegfried Oberndorfer
Siegfried Oberndorfer was a German physician and pathologist.Oberndorfer studied medicine in Munich and Kiel and Ph.D in 1900 in Munich and habilitated in pathological anatomy in 1906 also in Munich...
(1876-1944). Lubarsch also discovered tiny crystals in the epithelial cells of the testis that resemble sperm
Sperm
The term sperm is derived from the Greek word sperma and refers to the male reproductive cells. In the types of sexual reproduction known as anisogamy and oogamy, there is a marked difference in the size of the gametes with the smaller one being termed the "male" or sperm cell...
crystals. These structures are now known as Lubarsch' crystals.
With Friedrich Henke (1868-1943), he was editor of the Henke-Lubarsch Handbuch der Speziellen Pathologischen Anatomie und Histologie, which was a massive reference book containing information germane to pathology. It was founded in 1924, and produced over a forty year span. After World War II, it was continued and edited by Robert Rössle
Robert Rössle
Robert Rössle was a German pathologist who was born in Augsburg. In 1900 he received his medical doctorate from Munich, and went to work at the Pathological Institute of the University of Kiel...
(1876-1956). Also with veterinarian
Veterinarian
A veterinary physician, colloquially called a vet, shortened from veterinarian or veterinary surgeon , is a professional who treats disease, disorder and injury in animals....
Robert von Ostertag
Robert von Ostertag
Robert von Ostertag was a German veterinarian who was a native of Schwäbisch Gmünd.He studied medicine in Berlin and veterinary medicine in Stuttgart, and afterwards was a professor of hygiene at Tierärztliche Hochschule Stuttgart and at the College of Veterinary Medicine in Berlin...
(1864-1940) he collaborated on the journal Ergebnisse der allgemeinen Pathologie und pathologischen Anatomie der Menschen und der Tiere.
- Associated eponym:
- Lubarsch-Pick syndrome: A combination of systematized amyloidosisAmyloidosisIn medicine, amyloidosis refers to a variety of conditions whereby the body produces "bad proteins", denoted as amyloid proteins, which are abnormally deposited in organs and/or tissues and cause harm. A protein is described as being amyloid if, due to an alteration in its secondary structure, it...
with macroglossiaMacroglossiaMacroglossia is the medical term for unusual enlargement of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping.- Amyloid Disorders :...
. Named in conjunction with pathologist Ludwig PickLudwig PickProfessor Ludwig Pick was a German pathologist who was a native of Landsberg an der Warthe. In 1893 he earned his medical doctorate in Leipzig, and subsequently practiced medicine at Leopold Landau's private Frauenklinik, where he remained until 1906...
(1868-1944).