Noxiptiline
Encyclopedia
Noxiptiline also known as noxiptyline and dibenzoxine, is a tricyclic antidepressant
(TCA) that was introduced in Europe
in the 1970s for the treatment of depression. It has imipramine
-like effects, acting as a serotonin and norepinephrine reuptake inhibitor
, among other properties. Of the TCAs, noxiptiline has been shown to be one of the most effective, rivaling amitriptyline
in clinical efficacy.
Tricyclic antidepressant
Tricyclic antidepressants are heterocyclic chemical compounds used primarily as antidepressants. The TCAs were first discovered in the early 1950s and were subsequently introduced later in the decade; they are named after their chemical structure, which contains three rings of atoms...
(TCA) that was introduced in Europe
Europe
Europe is, by convention, one of the world's seven continents. Comprising the westernmost peninsula of Eurasia, Europe is generally 'divided' from Asia to its east by the watershed divides of the Ural and Caucasus Mountains, the Ural River, the Caspian and Black Seas, and the waterways connecting...
in the 1970s for the treatment of depression. It has imipramine
Imipramine
Imipramine , also known as melipramine, is an antidepressant medication, a tricyclic antidepressant of the dibenzazepine group...
-like effects, acting as a serotonin and norepinephrine reuptake inhibitor
Norepinephrine reuptake inhibitor
A norepinephrine reuptake inhibitor or adrenergic reuptake inhibitor , is a type of drug which acts as a reuptake inhibitor for the neurotransmitters norepinephrine and epinephrine by blocking the action of the norepinephrine transporter...
, among other properties. Of the TCAs, noxiptiline has been shown to be one of the most effective, rivaling amitriptyline
Amitriptyline
Amitriptyline is a tricyclic antidepressant . It is the most widely used TCA and has at least equal efficacy against depression as the newer class of SSRIs...
in clinical efficacy.