Myogenic regulatory factors
Encyclopedia
Myogenic regulatory factors are basic-helix-loop-helix
(bHLH) transcription factor
s that regulate myogenesis
: MyoD
, Myf5
, myogenin
, and MRF4.
These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif . They dimerize with other HLH
containing proteins through an HLH-HLH interaction.
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
(bHLH) transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...
s that regulate myogenesis
Myogenesis
Myogenesis is the formation of muscular tissue, in particular during embryonic development.Muscle fibers form from the fusion of myoblasts into multi-nucleated fibers . In the early development of an embryo these myoblasts will proliferate if enough fibroblast growth factor is present...
: MyoD
MyoD
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...
, Myf5
Myf5
Myf5 is a protein with a key role in regulating muscle differentiation.Myf5 belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD , myogenin, and MRF4 ....
, myogenin
Myogenin
Myogenin , also known as MYOG, is a gene.Myogenin is a muscle-specific basic-helix-loop-helix transcription factor involved in the coordination of skeletal muscle development and repair...
, and MRF4.
These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif . They dimerize with other HLH
Basic-helix-loop-helix
A basic helix-loop-helix is a protein structural motif that characterizes a family of transcription factors.- Structure :The motif is characterized by two α-helices connected by a loop. In general, transcription factors including this domain are dimeric, each with one helix containing basic amino...
containing proteins through an HLH-HLH interaction.