Myf5
Encyclopedia
Myf5 is a protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 with a key role in regulating muscle differentiation
Myogenesis
Myogenesis is the formation of muscular tissue, in particular during embryonic development.Muscle fibers form from the fusion of myoblasts into multi-nucleated fibers . In the early development of an embryo these myoblasts will proliferate if enough fibroblast growth factor is present...

.

Myf5 belongs to a family of proteins known as myogenic regulatory factors
Myogenic regulatory factors
Myogenic regulatory factors are basic-helix-loop-helix transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4.These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif . They dimerize with other HLH containing proteins through an HLH-HLH...

 (MRFs). These bHLH (basic helix loop helix) transcription factor
Transcription factor
In molecular biology and genetics, a transcription factor is a protein that binds to specific DNA sequences, thereby controlling the flow of genetic information from DNA to mRNA...

s act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD
MyoD
MyoD is a protein with a key role in regulating muscle differentiation. MyoD belongs to a family of proteins known as myogenic regulatory factors . These bHLH transcription factors act sequentially in myogenic differentiation. MRF family members include MyoD, Myf5, myogenin, and MRF4 .MyoD is one...

 (Myf3), myogenin
Myogenin
Myogenin , also known as MYOG, is a gene.Myogenin is a muscle-specific basic-helix-loop-helix transcription factor involved in the coordination of skeletal muscle development and repair...

, and MRF4 (Myf6).
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