Leroy Hood
Encyclopedia
Leroy Hood is an American
biologist
. He won the 2011 Fritz J. and Dolores H. Russ Prize “for automating DNA sequencing that revolutionized biomedicine and forensic science” and the 2003 Lemelson-MIT Prize
for inventing "four instruments that have unlocked much of the mystery of human biology" by helping decode the genome
. Hood also won the 2002 Kyoto Prize
for Advanced Technology, and the 1987 Albert Lasker Award for Basic Medical Research
. His inventions include the automated DNA sequencer and an automated tool for synthesizing DNA. Hood co-founded the Institute for Systems Biology
.
. He is recognized as one of the world's leading scientists in molecular biotechnology
and genomics
. He holds numerous patents and awards for his scientific breakthroughs and prides himself on his life-long commitment to making science accessible and understandable to the general public, especially children. One of this foremost goals is bringing hands-on, inquiry-based science to K-12 classrooms.
Hood was also a founding member of Amgen.
Dr. Hood earned an M.D. From Johns Hopkins University
in 1964 and a Ph.D. in biochemistry
from the California Institute of Technology
in 1968, supervised by William J. Dreyer
. Since then, his research has focused on the study of molecular immunology
and biotechnology
. Dr. Hood has published more than 600 peer-reviewed papers, received 14 patents, and co-authored textbooks in biochemistry, immunology, molecular biology, and genetics, and is a member of the National Academy of Sciences
, the American Philosophical Society
and the American Association of Arts and Sciences, the National Academy of Engineering
and the Institute of Medicine
. Hood received a D.Sc. from Bates College
in 1999.
His professional career began at Caltech where he and his colleagues pioneered four instruments--the automated DNA sequencer and synthesizer, and the protein synthesizer and sequencer--which comprise the technological foundation for contemporary molecular biology
. In particular, the DNA sequencer
has revolutionized genomics by allowing the rapid automated sequencing of DNA. Dr. Hood was also one of the first advocates of and is a key player in the Human Genome Project
--the quest to decipher the sequence of the human DNA. He also played a pioneering role in deciphering the secrets of antibody diversity.
In 1992, Dr. Hood moved to the University of Washington
to create the cross-disciplinary Department of Molecular Biotechnology. In his role as the Professor of Biomedical Science, Dr. Hood applied his laboratory expertise in DNA sequencing to the analysis of human and mouse immune receptors and initiated studies in prostate cancer, autoimmunity, and hematopoietic stem cell
development.
In 2000, Dr. Hood co-founded the Institute for Systems Biology
in Seattle, Washington to pioneer systems approaches to biology and medicine. He serves as President of the Institute and continues to pursue his interest in biology, medicine, technology, development, and computational biology.
Dr. Hood has played a role in founding numerous biotechnology companies, including Amgen
, Applied Biosystems
, Systemix, Darwin, Rosetta, and MacroGenics.
Dr. Hood was awarded the 1987 Lasker Prize for his studies on the mechanism of immune diversity; the Association of Biomolecular Resource Facilities
Award for outstanding contributions to Biomolecular Technologies in 2000; the 2002 Kyoto Prize
in Advanced Technology for technology development; the 2003 Lemelson-MIT Prize
for Innovation and Invention for the development of the DNA sequencer; the 12th Annual Heinz Award
in Technology, the Economy and Employment in 2006 for his extraordinary breakthroughs in biomedical science; and the 2006 Wharton Infosys Business Transformation Award for his society-transforming use of information technology. In 2007 he was inducted into the National Inventors Hall of Fame
.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
biologist
Biologist
A biologist is a scientist devoted to and producing results in biology through the study of life. Typically biologists study organisms and their relationship to their environment. Biologists involved in basic research attempt to discover underlying mechanisms that govern how organisms work...
. He won the 2011 Fritz J. and Dolores H. Russ Prize “for automating DNA sequencing that revolutionized biomedicine and forensic science” and the 2003 Lemelson-MIT Prize
Lemelson-MIT Prize
The Lemelson Foundation awards several prizes yearly to inventors in United States. The largest is the Lemelson-MIT Prize which was endowed in 1994 by Jerome H. Lemelson, and is administered through the Massachusetts Institute of Technology...
for inventing "four instruments that have unlocked much of the mystery of human biology" by helping decode the genome
Genome
In modern molecular biology and genetics, the genome is the entirety of an organism's hereditary information. It is encoded either in DNA or, for many types of virus, in RNA. The genome includes both the genes and the non-coding sequences of the DNA/RNA....
. Hood also won the 2002 Kyoto Prize
Kyoto Prize
The has been awarded annually since 1985 by the Inamori Foundation, founded by Kazuo Inamori. The prize is a Japanese award similar in intent to the Nobel Prize, as it recognizes outstanding works in the fields of philosophy, arts, science and technology...
for Advanced Technology, and the 1987 Albert Lasker Award for Basic Medical Research
Albert Lasker Award for Basic Medical Research
The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease...
. His inventions include the automated DNA sequencer and an automated tool for synthesizing DNA. Hood co-founded the Institute for Systems Biology
Institute for Systems Biology
The Institute for Systems Biology is a non-profit research institution, located in Seattle, Washington, United States. Leroy Hood co-founded the Institute with Alan Aderem and Ruedi Aebersold in 2000....
.
Biography
Dr. Leroy Hood was born October 10, 1938 in Missoula, MontanaMissoula, Montana
Missoula is a city located in western Montana and is the county seat of Missoula County. The 2010 Census put the population of Missoula at 66,788 and the population of Missoula County at 109,299. Missoula is the principal city of the Missoula Metropolitan Area...
. He is recognized as one of the world's leading scientists in molecular biotechnology
Biotechnology
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...
and genomics
Genomics
Genomics is a discipline in genetics concerning the study of the genomes of organisms. The field includes intensive efforts to determine the entire DNA sequence of organisms and fine-scale genetic mapping efforts. The field also includes studies of intragenomic phenomena such as heterosis,...
. He holds numerous patents and awards for his scientific breakthroughs and prides himself on his life-long commitment to making science accessible and understandable to the general public, especially children. One of this foremost goals is bringing hands-on, inquiry-based science to K-12 classrooms.
Hood was also a founding member of Amgen.
Dr. Hood earned an M.D. From Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...
in 1964 and a Ph.D. in biochemistry
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
from the California Institute of Technology
California Institute of Technology
The California Institute of Technology is a private research university located in Pasadena, California, United States. Caltech has six academic divisions with strong emphases on science and engineering...
in 1968, supervised by William J. Dreyer
William J. Dreyer
William J. Dreyer, Ph.D. was a molecular immunologist and California Institute of Technology professor of biology from 1963 to 2004.He completed his Ph.D. in biochemistry at the University of Washington in 1956...
. Since then, his research has focused on the study of molecular immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
and biotechnology
Biotechnology
Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purpose...
. Dr. Hood has published more than 600 peer-reviewed papers, received 14 patents, and co-authored textbooks in biochemistry, immunology, molecular biology, and genetics, and is a member of the National Academy of Sciences
United States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
, the American Philosophical Society
American Philosophical Society
The American Philosophical Society, founded in 1743, and located in Philadelphia, Pa., is an eminent scholarly organization of international reputation, that promotes useful knowledge in the sciences and humanities through excellence in scholarly research, professional meetings, publications,...
and the American Association of Arts and Sciences, the National Academy of Engineering
National Academy of Engineering
The National Academy of Engineering is a government-created non-profit institution in the United States, that was founded in 1964 under the same congressional act that led to the founding of the National Academy of Sciences...
and the Institute of Medicine
Institute of Medicine
The Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
. Hood received a D.Sc. from Bates College
Bates College
Bates College is a highly selective, private liberal arts college located in Lewiston, Maine, in the United States. and was most recently ranked 21st in the nation in the 2011 US News Best Liberal Arts Colleges rankings. The college was founded in 1855 by abolitionists...
in 1999.
His professional career began at Caltech where he and his colleagues pioneered four instruments--the automated DNA sequencer and synthesizer, and the protein synthesizer and sequencer--which comprise the technological foundation for contemporary molecular biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
. In particular, the DNA sequencer
DNA sequencer
A DNA sequencer is a scientific instrument used to automate the DNA sequencing process. It can be also considered an optical instrument as it generally analyses light signals originating from fluorochromes attached to nucleotides....
has revolutionized genomics by allowing the rapid automated sequencing of DNA. Dr. Hood was also one of the first advocates of and is a key player in the Human Genome Project
Human Genome Project
The Human Genome Project is an international scientific research project with a primary goal of determining the sequence of chemical base pairs which make up DNA, and of identifying and mapping the approximately 20,000–25,000 genes of the human genome from both a physical and functional...
--the quest to decipher the sequence of the human DNA. He also played a pioneering role in deciphering the secrets of antibody diversity.
In 1992, Dr. Hood moved to the University of Washington
University of Washington
University of Washington is a public research university, founded in 1861 in Seattle, Washington, United States. The UW is the largest university in the Northwest and the oldest public university on the West Coast. The university has three campuses, with its largest campus in the University...
to create the cross-disciplinary Department of Molecular Biotechnology. In his role as the Professor of Biomedical Science, Dr. Hood applied his laboratory expertise in DNA sequencing to the analysis of human and mouse immune receptors and initiated studies in prostate cancer, autoimmunity, and hematopoietic stem cell
Stem cell
This article is about the cell type. For the medical therapy, see Stem Cell TreatmentsStem cells are biological cells found in all multicellular organisms, that can divide and differentiate into diverse specialized cell types and can self-renew to produce more stem cells...
development.
In 2000, Dr. Hood co-founded the Institute for Systems Biology
Institute for Systems Biology
The Institute for Systems Biology is a non-profit research institution, located in Seattle, Washington, United States. Leroy Hood co-founded the Institute with Alan Aderem and Ruedi Aebersold in 2000....
in Seattle, Washington to pioneer systems approaches to biology and medicine. He serves as President of the Institute and continues to pursue his interest in biology, medicine, technology, development, and computational biology.
Dr. Hood has played a role in founding numerous biotechnology companies, including Amgen
Amgen
Amgen Inc. is an international biotechnology company headquartered in Thousand Oaks, California. Located in the Conejo Valley, Amgen is the world's largest independent biotech firm. The company employs approximately 17,000 staff members. Its products include Epogen, Aranesp, Enbrel, Kineret,...
, Applied Biosystems
Applied Biosystems
Applied Biosystems, Inc. started as GeneCo , was the name of a pioneer biotechnology company founded in 1981 in Foster City, California, in the San Francisco Bay Area...
, Systemix, Darwin, Rosetta, and MacroGenics.
Dr. Hood was awarded the 1987 Lasker Prize for his studies on the mechanism of immune diversity; the Association of Biomolecular Resource Facilities
Association of Biomolecular Resource Facilities
The Association of Biomolecular Resource Facilities is dedicated to advancing core and research biotechnology laboratories through research, communication, and education...
Award for outstanding contributions to Biomolecular Technologies in 2000; the 2002 Kyoto Prize
Kyoto Prize
The has been awarded annually since 1985 by the Inamori Foundation, founded by Kazuo Inamori. The prize is a Japanese award similar in intent to the Nobel Prize, as it recognizes outstanding works in the fields of philosophy, arts, science and technology...
in Advanced Technology for technology development; the 2003 Lemelson-MIT Prize
Lemelson-MIT Prize
The Lemelson Foundation awards several prizes yearly to inventors in United States. The largest is the Lemelson-MIT Prize which was endowed in 1994 by Jerome H. Lemelson, and is administered through the Massachusetts Institute of Technology...
for Innovation and Invention for the development of the DNA sequencer; the 12th Annual Heinz Award
Heinz Award
The Heinz Award is an award currently given annually to ten honorees by the Heinz Family Foundation. The Heinz Awards recognize outstanding individuals for their contributions in the five areas of: Arts and Humanities, the Environment, the Human Condition, Public Policy, and Technology, the Economy...
in Technology, the Economy and Employment in 2006 for his extraordinary breakthroughs in biomedical science; and the 2006 Wharton Infosys Business Transformation Award for his society-transforming use of information technology. In 2007 he was inducted into the National Inventors Hall of Fame
National Inventors Hall of Fame
The National Inventors Hall of Fame is a not-for-profit organization dedicated to recognizing, honoring and encouraging invention and creativity through the administration of its programs. The Hall of Fame honors the men and women responsible for the great technological advances that make human,...
.
External links
- My Life and Adventures Integrating Biology and Technology Commemorative lecture given when awarded the 2002 Kyoto Prize in Advanced Technologies.
- Biography of Leroy Hood at the website of the Institute for Systems BiologyInstitute for Systems BiologyThe Institute for Systems Biology is a non-profit research institution, located in Seattle, Washington, United States. Leroy Hood co-founded the Institute with Alan Aderem and Ruedi Aebersold in 2000....
. - Interview with Leroy Hood on the website of the Royal Society of ChemistryRoyal Society of ChemistryThe Royal Society of Chemistry is a learned society in the United Kingdom with the goal of "advancing the chemical sciences." It was formed in 1980 from the merger of the Chemical Society, the Royal Institute of Chemistry, the Faraday Society and the Society for Analytical Chemistry with a new...
. - The Heinz Awards, Leroy Hood profile
- SystemsX.ch - The Swiss Initiative in Systems Biology