Hydroxysteroid dehydrogenase
Encyclopedia
The Hydroxysteroid dehydrogenases are a group of alcohol oxidoreductases
that catalyze the dehydrogenation
of hydroxysteroid
s.
There are four types, classified by the number of the carbon acted upon:
Alcohol oxidoreductases
Alcohol oxidoreductases are oxidoreductase enzymes that act upon an alcohol functional group.They are classified under "1.1" in the EC number numbering system.-External links:...
that catalyze the dehydrogenation
Dehydrogenation
Dehydrogenation is a chemical reaction that involves the elimination of hydrogen . It is the reverse process of hydrogenation. Dehydrogenation reactions may be either large scale industrial processes or smaller scale laboratory procedures....
of hydroxysteroid
Hydroxysteroid
A hydroxysteroid is a molecule derived from a steroid with a hydrogen replaced with a hydroxy group....
s.
There are four types, classified by the number of the carbon acted upon:
| Carbon | From | To >- | 3 |
pregnenolone Pregnenolone Pregnenolone is a steroid hormone involved in the steroidogenesis of progesterone, mineralocorticoids, glucocorticoids, androgens, and estrogens. As such it is a prohormone. Pregnenolone sulfate is a GABAA antagonist and increases neurogenesis in the hippocampus.-Chemistry:Like other steroids,... |
progesterone Progesterone Progesterone also known as P4 is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species... >- | 3 |
17-Hydroxypregnenolone 17-Hydroxypregnenolone 17-Hydroxypregnenolone , is a C21 steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrial cytochrome P450 enzyme 17α-hydroxylase that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty... |
17-Hydroxyprogesterone 17-Hydroxyprogesterone 17-Hydroxyprogesterone is a C-21 steroid hormone produced during the synthesis of glucocorticoids and sex steroids.As a hormone, 17OHP also interacts with the progesterone receptor.-Production:... >- | 3 |
dehydroepiandrosterone Dehydroepiandrosterone 5-Dehydroepiandrosterone is a 19-carbon endogenous steroid hormone. It is the major secretory steroidal product of the adrenal glands and is also produced by the gonads and the brain. DHEA is the most abundant circulating steroid in humans.... |
androstenedione Androstenedione Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol.-Synthesis:Androstenedione is the common precursor of male and female sex... >- | 11 11Beta Hydroxysteroid dehydrogenase 11β-Hydroxysteroid dehydrogenase is the name of a family of enzymes that catalyze the conversion of inert 11 keto-products to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors.-Function:Cortisol, a glucocorticoid, binds the glucocorticoid... |
cortisol Cortisol Cortisol is a steroid hormone, more specifically a glucocorticoid, produced by the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat,... |
cortisone Cortisone Cortisone is a steroid hormone. It is one of the main hormones released by the adrenal gland in response to stress. In chemical structure, it is a corticosteroid closely related to corticosterone. It is used to treat a variety of ailments and can be administered intravenously, orally,... >- | 17 17Beta Hydroxysteroid dehydrogenase The 17β-hydroxysteroid dehydrogenases are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis.Note that the major reactions catalysed by 17β-HSD The 17β-hydroxysteroid dehydrogenases (17β-HSD enzymes) are a group of alcohol oxidoreductases... |
androstenedione Androstenedione Androstenedione is a 19-carbon steroid hormone produced in the adrenal glands and the gonads as an intermediate step in the biochemical pathway that produces the androgen testosterone and the estrogens estrone and estradiol.-Synthesis:Androstenedione is the common precursor of male and female sex... |
testosterone Testosterone Testosterone is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates. In mammals, testosterone is primarily secreted in the testes of males and the ovaries of females, although small amounts are also secreted by the adrenal glands... >- | 20 |
progesterone Progesterone Progesterone also known as P4 is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species... |
20-alpha-dihydroprogesterone 20-alpha-dihydroprogesterone 20α-Dihydroprogesterone is a reduced form of progesterone.... |