The 17β-hydroxysteroid dehydrogenases (17β-HSD enzymes) are a group of alcohol oxidoreductases

Alcohol oxidoreductases

Alcohol oxidoreductases are oxidoreductase enzymes that act upon an alcohol functional group.They are classified under "1.1" in the EC number numbering system.-External links:...

 which catalyse the dehydrogenation

Dehydrogenation

Dehydrogenation is a chemical reaction that involves the elimination of hydrogen . It is the reverse process of hydrogenation. Dehydrogenation reactions may be either large scale industrial processes or smaller scale laboratory procedures....

 of 17-hydroxysteroid

Hydroxysteroid

A hydroxysteroid is a molecule derived from a steroid with a hydrogen replaced with a hydroxy group....

s in steroidogenesis.

Note that the major reactions catalysed by 17β-HSD (e.g. the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.

Genes

Genes coding for 17β-HSD include:

• HSD17B1
  HSD17B1
  Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene.-Further reading:...
  
  
• HSD17B2
  HSD17B2
  Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.-Further reading:...
  
  
• HSD17B3
• HSD17B4
  HSD17B4
  Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene.-Further reading:...
  
  
• HSD17B6
  HSD17B6
  Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.-Further reading:...
  
  
• HSD17B7
  HSD17B7
  3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.-Further reading:...
  
  
• HSD17B8
  HSD17B8
  Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.-Further reading:...
  
  
• HSD17B10
  HSD17B10
  3-hydroxyacyl-CoA dehydrogenase type-2 is an enzyme that in humans is encoded by the HSD17B10 gene...
  
  
• HSD17B11
  HSD17B11
  Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.-Further reading:...
  
  
• HSD17B12
  HSD17B12
  Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.-Further reading:...
  
  
• HSD17B13
• HSD17B14

Clinical significance

Isozyme

Isozyme

Isozymes are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes usually display different kinetic parameters Isozymes (also known as isoenzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes...

 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency

17-beta-hydroxysteroid dehydrogenase deficiency

17-beta-hydroxysteroid dehydrogenase III deficiency is a rare disorder of sexual development affecting testosterone biosynthesis, which can produce impaired virilization of genetically male infants and children and excessive virilization of female adults.It is an autosomal recessive condition and...

.