17Beta Hydroxysteroid dehydrogenase
Encyclopedia
The 17β-hydroxysteroid dehydrogenases (17β-HSD enzymes) are a group of alcohol oxidoreductases
Alcohol oxidoreductases
Alcohol oxidoreductases are oxidoreductase enzymes that act upon an alcohol functional group.They are classified under "1.1" in the EC number numbering system.-External links:...

 which catalyse the dehydrogenation
Dehydrogenation
Dehydrogenation is a chemical reaction that involves the elimination of hydrogen . It is the reverse process of hydrogenation. Dehydrogenation reactions may be either large scale industrial processes or smaller scale laboratory procedures....

 of 17-hydroxysteroid
Hydroxysteroid
A hydroxysteroid is a molecule derived from a steroid with a hydrogen replaced with a hydroxy group....

s in steroidogenesis.

Note that the major reactions catalysed by 17β-HSD (e.g. the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.

Genes

Genes coding for 17β-HSD include:
  • HSD17B1
    HSD17B1
    Estradiol 17-beta-dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene.-Further reading:...

  • HSD17B2
    HSD17B2
    Estradiol 17-beta-dehydrogenase 2 is an enzyme that in humans is encoded by the HSD17B2 gene.-Further reading:...

  • HSD17B3
  • HSD17B4
    HSD17B4
    Peroxisomal multifunctional enzyme type 2 is a protein that in humans is encoded by the HSD17B4 gene.-Further reading:...

  • HSD17B6
    HSD17B6
    Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene.-Further reading:...

  • HSD17B7
    HSD17B7
    3-keto-steroid reductase is an enzyme that in humans is encoded by the HSD17B7 gene.-Further reading:...

  • HSD17B8
    HSD17B8
    Estradiol 17-beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.-Further reading:...

  • HSD17B10
    HSD17B10
    3-hydroxyacyl-CoA dehydrogenase type-2 is an enzyme that in humans is encoded by the HSD17B10 gene...

  • HSD17B11
    HSD17B11
    Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene.-Further reading:...

  • HSD17B12
    HSD17B12
    Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene.-Further reading:...

  • HSD17B13
  • HSD17B14

Clinical significance

Isozyme
Isozyme
Isozymes are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes usually display different kinetic parameters Isozymes (also known as isoenzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction. These enzymes...

 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency
17-beta-hydroxysteroid dehydrogenase deficiency
17-beta-hydroxysteroid dehydrogenase III deficiency is a rare disorder of sexual development affecting testosterone biosynthesis, which can produce impaired virilization of genetically male infants and children and excessive virilization of female adults.It is an autosomal recessive condition and...

.
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