HLA-B8
Encyclopedia
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| B*0801-β2MG with bound peptide | ||
| Alleles | B*0801 | |
| Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... ) |
Avail. 3D structures | |
| EBI-HLA European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
B*0801 | , , , , |
| Symbol(s) Human Genome Organisation The Human Genome Organisation is an organization involved in the Human Genome Project, a project about mapping the human genome. HUGO was established in 1989 as an international organization, primarily to foster collaboration between genome scientists around the world... |
HLA-B | |
| Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map... |
chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells... 6p21.31 |
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HLA-B8 (B8) is an HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...
-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...
serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...
. The serotype identifies the HLA-B*08 gene products. (For terminology help see: HLA-serotype tutorial) HLA-B8, previously known as HL-A8 was one of the first identified of the HLA antigens. It coined the "Super B8" haplotype, also called the ancestral European haplotype because of its common occurrence in Europe, particular the isles and Scandinavia. B8 is a component gene-allele of the AH8.1 haplotype
HLA A1-B8-DR3-DQ2
HLA A1-B8-DR3-DQ2 haplotype is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6...
in Northern and Western Europeans. Genes between B8 and DR3
HLA-DR3
HLA-DR3 is composed to the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease....
on this haplotype are frequently associated with autoimmune disease.
Serotype
| B*08 | B8 | Sample |
| allele | % | size (N) |
| 99 | 6508 | |
| 29 | 7 | |
| Allele links out to IMGT/HLA Human leukocyte antigen The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and... Databease at EBI European Bioinformatics Institute The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory... |
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Alleles
| freq | ||
| ref. | Population | (%) |
| Ireland South | 18.2 | |
| Australia New South Wales | 17.3 | |
| Ireland Northern | 16.2 | |
| Belgium | 12.6 | |
| Oman | 11.0 | |
| Spain Basque Gipuzkoa Province | 9.1 | |
| Finland | 8.9 | |
| France South East | 8.9 | |
| Scotland Orkney | 8.8 | |
| Morocco Nador Metalsa Class I | 8.7 | |
| India New Delhi | 8.3 | |
| Spain Eastern Andalusia Gipsy | 8.1 | |
| Madeira | 7.8 | |
| Guinea Bissau | 7.7 | |
| Iran Baloch | 7.6 | |
| South Africian Natal Zulu | 7.5 | |
| Brazil Belo Horizonte | 7.4 | |
| Cape Verde Southeastern Islands | 7.3 | |
| Romanian | 7.3 | |
| Saudi Arabia Guraiat and Hail | 7.1 | |
| South Africa Natal Tamil | 7.1 | |
| Georgia Svaneti Svans | 6.9 | |
| India Andhra Pradesh Golla | 6.7 | |
| Portugal North | 6.5 | |
| Azores Santa Maria and Sao Miguel | 6.4 | |
| Uganda Kampala | 6.2 | |
| Cape Verde Northwestern Islands | 5.6 | |
| Cameroon Yaounde | 5.4 | |
| Italy Bergamo | 5.3 | |
| Czech Republic | 5.2 | |
| Cameroon Pygmy Baka | 5.0 | |
| Senegal Niokholo Mandenka | 4.8 | |
| Kenya Nandi | 4.6 | |
| Spain Catalonia Girona | 4.6 | |
| Tunisia | 4.6 | |
| Bulgaria Gipsy | 4.5 | |
| Tunisia Tunis | 4.5 | |
| Brazil | 4.3 | |
| Portugal Centre | 4.0 | |
| Sudanese | 4.0 | |
| Cameroon Sawa | 3.8 | |
| Jordan Amman | 3.8 | |
| Indig. Australian, Cape York Peninsula | 3.5 | |
| Georgia Tibilisi Kurds | 3.4 | |
| Zambia Lusaka | 3.4 | |
| Kenya | 3.1 | |
| Zimbabwe Harare Shona | 3.1 | |
| Kenya Luo | 3.0 | |
| Mexico Zaptotec Oaxaca | 3.0 | |
| India North Hindus | 2.9 | |
| Mexico Mestizos | 2.4 | |
| Ivory Coast Akan Adiopodoume | 2.3 | |
| Indig. Australian, Groote Eylandt | 2.0 | |
| Portugal South | 2.0 | |
| Georgia Tibilisi Georgians | 1.9 | |
| Azores Central Islands | 1.8 | |
| Bulgaria | 1.8 | |
| Argentina Toba Rosario | 1.7 | |
| Croatia | 1.7 | |
| India North Delhi | 1.6 | |
| China North Han | 1.4 | |
| Cameroon Beti | 1.1 | |
| Cameroon Bakola Pygmy | 1.0 | |
| India West Coast Parsis | 1.0 | |
| Taiwan Siraya | 1.0 |