HLA-B (alpha)-β2MG with bound peptide
Alleles	*5801, *5802
Structure (See HLA-B HLA-B HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex... )
Shared data
Locus Locus (genetics) In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...	chr.6 Chromosome 6 (human) Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...  6p21.31

HLA-B58 (B58) is an HLA

Human leukocyte antigen

The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B

HLA-B

HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype

Serotype

Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. B58 is a split antigen from the B17

HLA-B17

HLA-B17 is an HLA - B serotype. B17 is a broad antigen serotype that recognizes the B57 and B58 split antigen serotypes. B17 is still encountered in the current literature, although most studies now use B57/B58 or gene typing designators. Both serotypes are involved in slightly different...

 broad antigen, the sister serotype B57

HLA-B57

HLA-B57 is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype B58. The serotype identifies the more common HLA-B*58 gene products...

. The serotype identifies the more common HLA-B*58 gene products. (For terminology help see: HLA-serotype tutorial) B*5801 is associated with allopurinol

Allopurinol

Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout.- Mechanism of action :...

 induced inflammatory necrotic skin disease.

Serotype

B58 and B17 serotype recognition of some more common HLA B*58 alleles

B*58	B58	B17	Sample
allele	%	%	size (N)
	79	4	2096
	72	3	837

Allele distribution

HLA B*5801 frequencies

		freq
ref.	Population	(%)
	Cameroon Pygmy Baka	15.0
	India Khandesh Pawra	15.0
	Cameroon Sawa	11.5
	Taiwan Hakka	10.9
	Kenya Nandi	10.0
	India West Bhils	9.0
	China South Han	8.9
	China Inner Mongolia	8.8
	India North Delhi	8.8
	Thailand Northeast	8.4
	Guinea Bissau	7.8
	Thailand	7.7
	India Mumbai Marathas	7.4
	India Andhra Pradesh Golla	7.2
	Kenya Luo	7.0
	Senegal Niokholo Mandenka	6.9
	India New Delhi	6.8
	Oman	6.8
	Russia Tuva (2)	6.7
	South Korea (3)	6.5
	Italy Sardinia (3)	6.4
	Burkina Faso Fulani	6.1
	Taiwan Siraya	5.9
	India North Hindus	5.8
	Burkina Faso Mossi	5.7
	Cameroon Yaounde	5.4
	Cameroon Bamileke	5.2
	Singapore Riau Malay	5.0
	Saudi Arabia Guraiat and Hail	4.6
	France Corsica	4.5
	Sudanese	4.5
	Zimbabwe Harare Shona	4.4
	Burkina Faso Rimaibe	4.3
	Iran Baloch	4.0
	South Africian Natal Zulu	4.0
	Tunisia	4.0
	Uganda Kampala	4.0
	Cameroon Beti	3.7
	Tunisia Ghannouch	3.7
	Taiwan Pazeh	3.6
	Tunisia Tunis	3.4
	Italy North (1)	3.3
	Israel Ashkenazi and Non Ashkenazi Jews	3.2
	India West Coast Parsis	3.0
	China North Han	2.9
	Ivory Coast Akan Adiopodoume	2.3
	Mali Bandiagara	2.2
	Mexico Zaptotec Oaxaca	2.2
	South Africa Natal Tamil	2.0
	China Yunnan Nu	1.9
	Bulgaria	1.8
	China Tibet Autonomous Region Tibetans	1.6
	France South East	1.6
	Israel Arab Druse	1.5
	Czech Republic	1.4
	Georgia Tibilisi Georgians	1.4
	Jordan Amman	1.4
	Morocco Nador Metalsa (berber)	1.4
	Croatia	1.3
	Romanian	1.3
	Spain Eastern Andalusia	1.2
	Australian Aborigine Cape York Peninsula	1.0
	B*5802
	Cameroon Bamileke	14.3
	Kenya Luo	12.5
	Cameroon Yaounde	10.9
	Cameroon Pygmy Baka	10.0
	Cameroon Beti	9.8
	Kenya Nandi	8.5
	South Africian Natal Zulu	8.5
	Cameroon Sawa	7.7
	Zimbabwe Harare Shona	6.4
	Cape Verde Northwestern Islands	5.6
	Uganda Kampala	4.4
	Central Africa Republic Mbenzele Pygmy	4.0
	Zambia Lusaka	2.3
	Iran Baloch	1.0
	Tunisia	1.0

Disease

HLA-B*5801 is involved in allopurinol sensitive drug induced Stevens–Johnson syndrome. Allopurinol is a frequent cause of severe cutaneous adverse reactions, including drug-hypersensitivity syndrome, Stevens–Johnson syndrome, and toxic epidermal necrolysis (SJS/TEN). The association with allopurinol sensitivity in JSJ/TEN was extremely strong in Asia, and somewhat less associated in Europeans.