HLA-B14
Encyclopedia
HLA-B (alpha)-β2MG with bound peptide
Alleles B*1401, 1402 . .
Structure (See HLA-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

)
Shared data
Locus
Locus (genetics)
In the fields of genetics and genetic computation, a locus is the specific location of a gene or DNA sequence on a chromosome. A variant of the DNA sequence at a given locus is called an allele. The ordered list of loci known for a particular genome is called a genetic map...

chr.6
Chromosome 6 (human)
Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs and represents between 5.5 and 6% of the total DNA in cells...

 6p21.31

HLA-B14 (B14) is a HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

-B
HLA-B
HLA-B is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen complex...

 serotype
Serotype
Serotype or serovar refers to distinct variations within a subspecies of bacteria or viruses. These microorganisms, viruses, or cells are classified together based on their cell surface antigens...

. The serotype identifies the B*45 gene-allele protein products of HLA-B.
B14 is a broad antigen composed to two, B64 and B65, split antigens. In the case of B14 the recognition of the broad antigen is more useful than split antigen recognition because of the relatively poor discrimination of the split antigens (see Table below).

Serotype

B14, B64, B65 serotype recognition of some
HLA B*14 allele-group gene products
B*14 B14 B64 B65 Sample
allele % % % size (N)
72 10 10 1006
71 2 25 2244
50 35 40
Alleles link-out to IMGT/HLA
Human leukocyte antigen
The human leukocyte antigen system is the name of the major histocompatibility complex in humans. The super locus contains a large number of genes related to immune system function in humans. This group of genes resides on chromosome 6, and encodes cell-surface antigen-presenting proteins and...

 Databease at EBI
European Bioinformatics Institute
The European Bioinformatics Institute is a centre for research and services in bioinformatics, and is part of European Molecular Biology Laboratory...


HLA-B64

This serotype does not have good recognition of any of the alleles, relatively speaking recognizes B*1401 better.

HLA-B65

This serotype recognizes B*1402 and B*1403 but less so than B14 and to a minor degree it recognized B*1401.


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