Guanosine diphosphate mannose
Encyclopedia
Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar
that is a substrate for glycosyltransferase
reactions in metabolism
. This compound is a substrate for enzymes called mannosyltransferase
s.
and mannose-6-phosphate
by the enzyme mannose-1-phosphate guanylyltransferase
.
Nucleotide sugar
Nucleotide sugars are the activated forms of monosaccharides. Nucleotide sugars act as glycosyl donors in glycosylation reactions. Those reactions are catalyzed by a group of enzymes called glycosyltransferases.-History:...
that is a substrate for glycosyltransferase
Glycosyltransferase
Glycosyltransferases are enzymes that act as a catalyst for the transfer of a monosaccharide unit from an activated nucleotide sugar to a glycosyl acceptor molecule, usually an alcohol....
reactions in metabolism
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
. This compound is a substrate for enzymes called mannosyltransferase
Mannosyltransferase
A mannosyltransferase is a type of glycosyltransferase that acts upon mannose.An example is heteroglycan alpha-mannosyltransferase....
s.
Biosynthesis
GDP-mannose is produced from GTPGuanosine triphosphate
Guanosine-5'-triphosphate is a purine nucleoside triphosphate. It can act as a substrate for the synthesis of RNA during the transcription process...
and mannose-6-phosphate
Mannose-6-phosphate
Mannose-6-phosphate is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase....
by the enzyme mannose-1-phosphate guanylyltransferase
Mannose-1-phosphate guanylyltransferase
In enzymology, a mannose-1-phosphate guanylyltransferase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are GTP and alpha-D-mannose 1-phosphate, whereas its two products are diphosphate and GDP-mannose....
.
See also
- NucleosideNucleosideNucleosides are glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage...
- NucleotideNucleotideNucleotides are molecules that, when joined together, make up the structural units of RNA and DNA. In addition, nucleotides participate in cellular signaling , and are incorporated into important cofactors of enzymatic reactions...
- GuanosineGuanosineGuanosine is a purine nucleoside comprising guanine attached to a ribose ring via a β-N9-glycosidic bond. Guanosine can be phosphorylated to become guanosine monophosphate , cyclic guanosine monophosphate , guanosine diphosphate , and guanosine triphosphate...
- Guanosine diphosphateGuanosine diphosphateGuanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate. It is an ester of pyrophosphoric acid with the nucleoside guanosine. GDP consists of the pyrophosphate group, the pentose sugar ribose, and the nucleobase guanine....