Glutamate-1-semialdehyde
Encyclopedia
This file may be error. The precursor to ornithine and proline is thought to be glutamate-5-semialdehyde. See, for instance, Thomas M. Devlin, Textbook of Biochemistry with Clinical Correlations, Sixth Edition, p. 755 (Figure 19.28) and p. 756 (Figure 19.29).
Glutamate-1-semialdehyde is a molecule formed from glutamate, and is a precursor to ornithine
and proline
.
It is an intermediate in the metabolism of histidine
, with the immediate precursor being formiminoglutamic acid
.
Glutamate-1-semialdehyde is a molecule formed from glutamate, and is a precursor to ornithine
Ornithine
Ornithine is an amino acid that plays a role in the urea cycle.-Role in urea cycle:L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen....
and proline
Proline
Proline is an α-amino acid, one of the twenty DNA-encoded amino acids. Its codons are CCU, CCC, CCA, and CCG. It is not an essential amino acid, which means that the human body can synthesize it. It is unique among the 20 protein-forming amino acids in that the α-amino group is secondary...
.
It is an intermediate in the metabolism of histidine
Histidine
Histidine Histidine, an essential amino acid, has a positively charged imidazole functional group. It is one of the 22 proteinogenic amino acids. Its codons are CAU and CAC. Histidine was first isolated by German physician Albrecht Kossel in 1896. Histidine is an essential amino acid in humans...
, with the immediate precursor being formiminoglutamic acid
Formiminoglutamic acid
Formiminoglutamic acid is an intermediate in the metabolism of histidine.The "FIGLU" test is used to identify deficiency of vitamin B12 or folate deficiency or liver disease.-See also:* Imidazol-4-one-5-propionic acid...
.