2001    US President George W. Bush announces his support for federal funding of limited research on embryonic stem cells.

2001    In an address to a joint session of Congress and the American people, U.S. President George W. Bush declares a "war on terror".

2001    U.S. President George W. Bush announces the establishment of the Office of Homeland Security.

2001    War on Terrorism: In the first such act since World War II, US President George W. Bush signs an executive order allowing military tribunals against foreigners suspected of connections to terrorist acts or planned acts on the United States.

2001    In Washington, D.C., U.S. President George W. Bush dedicates the United States Department of Justice headquarters building as the Robert F. Kennedy Justice Building, honoring the late Robert F. Kennedy on what would have been his 76th birthday.

2002    President George W. Bush signs into law the No Child Left Behind Act.

2002    In his State of the Union Address, President George W. Bush describes "regimes that sponsor terror" as an ''Axis of Evil'', in which he includes Iraq, Iran and North Korea.

2003    2003 invasion of Iraq: In what becomes known as the "Mission Accomplished" speech, on board the {{USS|Abraham Lincoln|CVN-72|6}} (off the coast of California), U.S. President George W. Bush declares that "major combat operations in Iraq have ended".

2003    From the flight deck of the USS Abraham Lincoln, US President George W. Bush announced in a nationally televised address in front of a "Mission Accomplished" banner that major combat operations in Iraq had ended.

2003    President George W. Bush signs the CAN-SPAM Act of 2003 into law. The law establishes the United States' first national standards for the sending of commercial e-mail and requires the Federal Trade Commission to enforce its provisions.