Friedrich Daniel von Recklinghausen (ˈʁɛklɪŋhaʊzən; 1833–1910) was a German

Germany

Germany , officially the Federal Republic of Germany , is a federal parliamentary republic in Europe. The country consists of 16 states while the capital and largest city is Berlin. Germany covers an area of 357,021 km2 and has a largely temperate seasonal climate...

 pathologist who practiced medicine in Würzburg

Würzburg

Würzburg is a city in the region of Franconia which lies in the northern tip of Bavaria, Germany. Located at the Main River, it is the capital of the Regierungsbezirk Lower Franconia. The regional dialect is Franconian....

 (1866–1872) and Strassburg

Strasbourg

Strasbourg is the capital and principal city of the Alsace region in eastern France and is the official seat of the European Parliament. Located close to the border with Germany, it is the capital of the Bas-Rhin département. The city and the region of Alsace are historically German-speaking,...

 (1872–1906). Born in Gütersloh

Gütersloh

Gütersloh is a city in North Rhine-Westphalia, in the area of Westphalia and the administrative region of Detmold. Gütersloh is the administrative centre for a district of the same name and has a population of 96,320 people.- Geography :...

, Westphalia

Province of Westphalia

The Province of Westphalia was a province of the Kingdom of Prussia and the Free State of Prussia from 1815 to 1946.-History:Napoleon Bonaparte founded the Kingdom of Westphalia, which was a client state of the First French Empire from 1807 to 1813...

, he was the father of physiologist Heinrich von Recklinghausen

Heinrich von Recklinghausen

Heinrich von Recklinghausen was a German physician and scientist from Würzburg. After receiving his medical doctorate in 1895, he worked as an assistant in several hospitals. In 1902 he moved to Bern, where he worked in the Physiological Institute of Hugo Kronecker...

 (1867–1942).

In 1882 Recklinghausen released a monograph which reviewed previous literature and characterized the tumors of Neurofibromatosis type I

Neurofibromatosis type I

Neurofibromatosis type I , formerly known as von Recklinghausen disease after the researcher who first documented the disorder, is a human genetic disorder. It is possibly the most common inherited disorder caused by a single gene...

 or NF-1 as neurofibroma

Neurofibroma

A neurofibroma is a benign nerve sheath tumor in the peripheral nervous system. Usually found in individuals with neurofibromatosis type I , an autosomal dominant genetically-inherited disease, they can result in a range of symptoms from physical disfiguration and pain to cognitive disability...

s, consisting of an intense commingling of nerve cells and fibrous tissue. NF-1 is sometimes referred to as von Recklinghausen syndrome.

In 1889 Recklinghausen coined the term "haemochromatosis

Haemochromatosis

Haemochromatosis type 1 is a hereditary disease characterized by excessive intestinal absorption of dietary iron resulting in a pathological increase in total body iron stores. Humans, like most animals, have no means to excrete excess iron...

", and was the first to provide the link between haemochromatosis and iron accumulation in body tissue. This disease was initially described in 1865 by Armand Trousseau

Armand Trousseau

Armand Trousseau was a French internist. His contributions to medicine include Trousseau sign of malignancy, Trousseau sign of latent tetany, Trousseau-Lallemand bodies , and the truism, "use new drugs quickly, while they still work."-Biography:A native of Tours, Indre-et-Loire, Armand Trousseau...

. Recklinghausen published his findings in Hämochromatose, Tageblatt der Naturforschenden Versammlung. He also established a method of staining the lines of cell junctions with silver

Silver

Silver is a metallic chemical element with the chemical symbol Ag and atomic number 47. A soft, white, lustrous transition metal, it has the highest electrical conductivity of any element and the highest thermal conductivity of any metal...

, a procedure that led to Julius Friedrich Cohnheim’s research on leukocyte migration and inflammation. In 1910, he coined the term oncosis (derived from ónkos, meaning swelling). This term is sometimes used to describe Ischemic cell death

Ischemic cell death

Ischemic cell death, or Oncosis, is a form of accidental, or passive cell death that is oftentimes considered a lethal injury. The process is characterized by mitochondrial swelling, cytoplasm vacuolization, and swelling of the nucleus and cytoplasm....

. Recklinghausen died in Strassburg.