FYVE domain
Encyclopedia
FYVE zinc finger domain is named after the four cysteine-rich protein
s: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1
, in which it has been found.
The FYVE finger binds two zinc
ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.
FYVE domains bind Phosphatidylinositol 3-phosphate
, in a way dependent on its metal ion coordination and basic amino acids. It has been speculated these bindings cause conformational changes or regulate protein-protein or lipid-protein interactions.
The FYVE finger is structurally similar to the RING domain and the PHD finger
.
The FYVE domain has been connected to vacuolar protein sorting and endosome function.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
s: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1
EEA1
EEA1 is Early Endosome Antigen 1 protein that binds phospholipid vesicles containing phosphatidylinositol 3-phosphate, which is necessary for endosomal trafficking. It binds lipids through its FYVE domain and forms a homodimer through a coiled coil domain....
, in which it has been found.
The FYVE finger binds two zinc
Zinc
Zinc , or spelter , is a metallic chemical element; it has the symbol Zn and atomic number 30. It is the first element in group 12 of the periodic table. Zinc is, in some respects, chemically similar to magnesium, because its ion is of similar size and its only common oxidation state is +2...
ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue.
FYVE domains bind Phosphatidylinositol 3-phosphate
Phosphatidylinositol 3-phosphate
Phosphatidylinositol 3-phosphate is a phospholipid found in cell membranes that helps to recruit a range of proteins, many of which are involved in protein trafficking, to the membranes...
, in a way dependent on its metal ion coordination and basic amino acids. It has been speculated these bindings cause conformational changes or regulate protein-protein or lipid-protein interactions.
The FYVE finger is structurally similar to the RING domain and the PHD finger
PHD finger
The PHD finger was discovered in 1993 as a Cys4-His-Cys3 motif in the homeodomain protein HAT3 in Arabidopsis thaliana.The PHD finger motif resembles the metal binding RING domain and FYVE domain...
.
The FYVE domain has been connected to vacuolar protein sorting and endosome function.
Examples
The following is a list of human proteins containing this domain:- ANKFY1ANKFY1Ankyrin repeat and FYVE domain-containing protein 1 is a protein that in humans is encoded by the ANKFY1 gene.-Further reading:...
- EEA1EEA1EEA1 is Early Endosome Antigen 1 protein that binds phospholipid vesicles containing phosphatidylinositol 3-phosphate, which is necessary for endosomal trafficking. It binds lipids through its FYVE domain and forms a homodimer through a coiled coil domain....
- FGD1FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome....
; FGD2FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome....
; FGD3FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome....
; FGD4FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome....
; FGD5FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome....
; FGD6FYVE, RhoGEF and PH domain containingFYVE, RhoGEF and PH domain containing is a gene family consisting of:* FGD1* FGD2* FGD3* FGD4Type 1 is associated with Aarskog-Scott syndrome.... - FYCO1
- HGSHGS (gene)Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.-Interactions:HGS has been shown to interact with TSG101, STAM2, Merlin, DLG4, IL2RB, EPS15, CLTC and Signal transducing adaptor molecule.-Further reading:...
- MTMR3MTMR3Myotubularin-related protein 3 is a protein that in humans is encoded by the MTMR3 gene.-References:...
; MTMR4 - PIKFYVE; PLEKHF1; PLEKHF2PLEKHF2Pleckstrin homology domain-containing family F member 2 is a protein that in humans is encoded by the PLEKHF2 gene.-Further reading:...
- RUFY1RUFY1RUN and FYVE domain-containing protein 1 is a protein that in humans is encoded by the RUFY1 gene. It is named after the RUN and FYVE domains it contains.-Interactions:RUFY1 has been shown to interact with BMX.-Further reading:...
; RUFY2 - WDF3; WDFY1; WDFY2; WDFY3WDFY3WD repeat and FYVE domain-containing protein 3 is a protein that in humans is encoded by the WDFY3 gene.-Further reading:...
- ZFYVE1ZFYVE1Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene.-Further reading:...
; ZFYVE16ZFYVE16Zinc finger FYVE domain-containing protein 16 is a protein that in humans is encoded by the ZFYVE16 gene.-Further reading:...
; ZFYVE19ZFYVE19Zinc finger FYVE domain-containing protein 19 is a protein that in humans is encoded by the ZFYVE19 gene.-Further reading:...
; ZFYVE20ZFYVE20Rabenosyn-5 is a protein that in humans is encoded by the ZFYVE20 gene.-Further reading:...
; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9
Further reading
- Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054.
- FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433.
- FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183.
External links
- Zinc finger FYVE/FYVE-related type in PROSITEPROSITEPROSITE is a protein database. It consists of entries describing the protein families, domains and functional sites as well as amino acid patterns, signatures, and profiles in them. These are manually curated by a team of the Swiss Institute of Bioinformatics and tightly integrated into Swiss-Prot...
- FYVE domain in Pfam - Orientations of FYVE/PHD zinc finger domains in membranes (OPM)