Endometrin Vaginal Insert 100 mg is a brand of micronized progesterone

Progesterone

Progesterone also known as P4 is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species...

 inserts from Ferring Pharmaceuticals

Ferring Pharmaceuticals

Ferring Pharmaceuticals is a pharmaceutical company that specializes in the development and marketing of drugs for use in human medicine.It was founded by Frederik Paulsen Sr in Malmö, Sweden, in 1950, initially as the Nordiska Hormon Laboratoriet, renamed Ferring in 1954. A ferring in Frisian is a...

 in Parsippany, New Jersey, which was FDA-approved in June 2007 for use in the United States.

Inactive ingredients include lactose monohydrate, polyvinylpyrrolidone, adipic acid, and sodium bicarbonate. Other progesterone

Progesterone

Progesterone also known as P4 is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species...

 formulations—via oral pill or intramuscular injection

Injection (medicine)

An injection is an infusion method of putting fluid into the body, usually with a hollow needle and a syringe which is pierced through the skin to a sufficient depth for the material to be forced into the body...

—contain peanut or sesame oil, which may cause allergic reactions in some people. Endometrin is free of these substances.

Endometrin is used to support embryo

Embryo

An embryo is a multicellular diploid eukaryote in its earliest stage of development, from the time of first cell division until birth, hatching, or germination...

 implantation and early pregnancy

Pregnancy

Pregnancy refers to the fertilization and development of one or more offspring, known as a fetus or embryo, in a woman's uterus. In a pregnancy, there can be multiple gestations, as in the case of twins or triplets...

 by supplementation of corpus luteal function as part of an Assisted Reproductive Technology

Assisted reproductive technology

Assisted reproductive technology is a general term referring to methods used to achieve pregnancy by artificial or partially artificial means. It is reproductive technology used primarily in infertility treatments. Some forms of ART are also used in fertile couples for genetic reasons...

 (ART) treatment program for infertile women.

The dose of Endometrin is a 100-mg insert, administered vaginally two or three times daily starting the day after egg retrieval and continuing for up to 10 weeks' total duration. The safety and effectiveness of Endometrin was demonstrated in the largest US IVF trial to date including 1,211 women.

Indication

Endometrin administered as a progesterone vaginal insert is indicated to support embryo implantation and early pregnancy by supplementation of corpus luteal function as part of an Assisted Reproductive Technology (ART) treatment for infertile women.

Important Safety Information

Only physicians thoroughly familiar with infertility treatment should prescribe Endometrin. In clinical trials (n=808), adverse reactions that occurred at a rate greater than or equal to 2% included: uterine spasm (3% to 4%) and vaginal bleeding (3%). Vaginal irritation, itching, burning or discomfort, urticaria, and peripheral edema were reported at an incidence of less than 2%. Endometrin is expected to have adverse reactions similar to other drugs containing progesterone (breast tenderness, bloating, mood swings, irritability, and drowsiness).