Edward Abraham
Encyclopedia
Edward Penley Abraham, CBE
, FRS (June 10, 1913 – 8 May 1999) was an English biochemist
instrumental in the development of penicillin
.
and attended King Edward VI School, Southampton
before achieving a First in chemistry
at The Queen’s College, Oxford.
After completing his doctorate in Oxford
, Abraham took up a position at the Sir William Dunn School of Pathology
.
He became part of a research team led by Professor Howard Florey responsible for the development of penicillin and its medical applications. Sir Edward was specifically involved in the purification process and determination of its chemical structure
. Florey formally recognised Abraham’s work in 1948 by nominating him to be one of the first three “penicillin” research Fellows at Lincoln College, Oxford
. He was a Fellow of Lincoln until his retirement in 1980.
Abraham was the recipient of many awards over his lifetime, including a CBE
in 1973 and a knighthood in 1980. He was elected a Foreign Honorary Member of the American Academy of Arts and Sciences
in 1983. He was elected to the fellowship of the Royal Society
in 1958.
He died in May 1999, in Oxford, following a stroke. He was survived by his wife, Asbjörg.
s producing great clinical advances. His principal work was concerned with the development of penicillin, and also later cephalosporin
, an antibiotic capable of destroying penicillin-resistant bacteria. These vital drugs are now used extensively in the treatment of various infection
s, including pneumonia
, bronchitis
, septicaemia and infected surgical wounds.
Through the registration of the patent
on cephalosporin, he was able to generate a regular income, which he devoted almost entirely to the establishment of two charitable trusts for the support of biomedical research, the Edward Penley Abraham Research Fund and the E P A Cephalosporin Fund. By the end of the twentieth century, the charitable funds had donated more than £30m to the University of Oxford
, mainly to the Dunn School of Pathology and to Lincoln College, along with other grants to The Royal Society and King Edward VI School, Southampton. Two recent Oxford
buildings — the Edward Abraham research building (on South Parks Road
) and the Lincoln EPA Science Centre (on Museum Road
) — are named after him.
Order of the British Empire
The Most Excellent Order of the British Empire is an order of chivalry established on 4 June 1917 by George V of the United Kingdom. The Order comprises five classes in civil and military divisions...
, FRS (June 10, 1913 – 8 May 1999) was an English biochemist
Biochemistry
Biochemistry, sometimes called biological chemistry, is the study of chemical processes in living organisms, including, but not limited to, living matter. Biochemistry governs all living organisms and living processes...
instrumental in the development of penicillin
Penicillin
Penicillin is a group of antibiotics derived from Penicillium fungi. They include penicillin G, procaine penicillin, benzathine penicillin, and penicillin V....
.
Life
He was born in Shirley, SouthamptonShirley, Southampton
Shirley is a district on the Western side of Southampton, England. Shirley's main roles are retailing and residential. It is the most important suburban shopping area in the west of the city. Housing is a mixture of council houses in the centre of the district surrounded by private housing, with...
and attended King Edward VI School, Southampton
King Edward VI School, Southampton
King Edward VI School, often referred to as King Edward's, or simply KES, is a selective co-educational independent day School located in Southampton, United Kingdom and is a member of the Headmasters' and Headmistresses' Conference. It was founded in 1553, after the death of William Capon , who...
before achieving a First in chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
at The Queen’s College, Oxford.
After completing his doctorate in Oxford
University of Oxford
The University of Oxford is a university located in Oxford, United Kingdom. It is the second-oldest surviving university in the world and the oldest in the English-speaking world. Although its exact date of foundation is unclear, there is evidence of teaching as far back as 1096...
, Abraham took up a position at the Sir William Dunn School of Pathology
Sir William Dunn School of Pathology
The Sir William Dunn School of Pathology is a Department within the University of Oxford . Its research programme includes the cellular and molecular biology of pathogens, the immune response, cancer and cardiovascular disease...
.
He became part of a research team led by Professor Howard Florey responsible for the development of penicillin and its medical applications. Sir Edward was specifically involved in the purification process and determination of its chemical structure
Chemical structure
A chemical structure includes molecular geometry, electronic structure and crystal structure of molecules. Molecular geometry refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together. Molecular geometry can range from the very simple, such as...
. Florey formally recognised Abraham’s work in 1948 by nominating him to be one of the first three “penicillin” research Fellows at Lincoln College, Oxford
Lincoln College, Oxford
Lincoln College is one of the constituent colleges of the University of Oxford in the United Kingdom. It is situated on Turl Street in central Oxford, backing onto Brasenose College and adjacent to Exeter College...
. He was a Fellow of Lincoln until his retirement in 1980.
Abraham was the recipient of many awards over his lifetime, including a CBE
Order of the British Empire
The Most Excellent Order of the British Empire is an order of chivalry established on 4 June 1917 by George V of the United Kingdom. The Order comprises five classes in civil and military divisions...
in 1973 and a knighthood in 1980. He was elected a Foreign Honorary Member of the American Academy of Arts and Sciences
American Academy of Arts and Sciences
The American Academy of Arts and Sciences is an independent policy research center that conducts multidisciplinary studies of complex and emerging problems. The Academy’s elected members are leaders in the academic disciplines, the arts, business, and public affairs.James Bowdoin, John Adams, and...
in 1983. He was elected to the fellowship of the Royal Society
Royal Society
The Royal Society of London for Improving Natural Knowledge, known simply as the Royal Society, is a learned society for science, and is possibly the oldest such society in existence. Founded in November 1660, it was granted a Royal Charter by King Charles II as the "Royal Society of London"...
in 1958.
He died in May 1999, in Oxford, following a stroke. He was survived by his wife, Asbjörg.
Achievements
He was a noted biochemist, his work on antibioticAntibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
s producing great clinical advances. His principal work was concerned with the development of penicillin, and also later cephalosporin
Cephalosporin
The cephalosporins are a class of β-lactam antibiotics originally derived from Acremonium, which was previously known as "Cephalosporium".Together with cephamycins they constitute a subgroup of β-lactam antibiotics called cephems.-Medical use:...
, an antibiotic capable of destroying penicillin-resistant bacteria. These vital drugs are now used extensively in the treatment of various infection
Infection
An infection is the colonization of a host organism by parasite species. Infecting parasites seek to use the host's resources to reproduce, often resulting in disease...
s, including pneumonia
Pneumonia
Pneumonia is an inflammatory condition of the lung—especially affecting the microscopic air sacs —associated with fever, chest symptoms, and a lack of air space on a chest X-ray. Pneumonia is typically caused by an infection but there are a number of other causes...
, bronchitis
Bronchitis
Acute bronchitis is an inflammation of the large bronchi in the lungs that is usually caused by viruses or bacteria and may last several days or weeks. Characteristic symptoms include cough, sputum production, and shortness of breath and wheezing related to the obstruction of the inflamed airways...
, septicaemia and infected surgical wounds.
Through the registration of the patent
Patent
A patent is a form of intellectual property. It consists of a set of exclusive rights granted by a sovereign state to an inventor or their assignee for a limited period of time in exchange for the public disclosure of an invention....
on cephalosporin, he was able to generate a regular income, which he devoted almost entirely to the establishment of two charitable trusts for the support of biomedical research, the Edward Penley Abraham Research Fund and the E P A Cephalosporin Fund. By the end of the twentieth century, the charitable funds had donated more than £30m to the University of Oxford
University of Oxford
The University of Oxford is a university located in Oxford, United Kingdom. It is the second-oldest surviving university in the world and the oldest in the English-speaking world. Although its exact date of foundation is unclear, there is evidence of teaching as far back as 1096...
, mainly to the Dunn School of Pathology and to Lincoln College, along with other grants to The Royal Society and King Edward VI School, Southampton. Two recent Oxford
Oxford
The city of Oxford is the county town of Oxfordshire, England. The city, made prominent by its medieval university, has a population of just under 165,000, with 153,900 living within the district boundary. It lies about 50 miles north-west of London. The rivers Cherwell and Thames run through...
buildings — the Edward Abraham research building (on South Parks Road
South Parks Road
South Parks Road is a road in Oxford, England. It runs east-west past the main Science Area of the University of Oxford, where many of the science departments are located....
) and the Lincoln EPA Science Centre (on Museum Road
Museum Road
Museum Road is a short road in central Oxford, England. It leads to the Oxford University Museum of Natural History and the Radcliffe Science Library at its eastern end where it meets Parks Road. At its west end is a junction with Blackhall Road. It continues as the Lamb & Flag Passage past the...
) — are named after him.