CP 47,497
Encyclopedia
CP 47,497 is a cannabinoid receptor agonist drug, developed by Pfizer
in the 1980s. It has analgesic
effects and is used in scientific research. It is a potent CB1 agonist with a Kd
of 2.1nM.
of CP 47,497 is the main active ingredient in the herbal "incense" product Spice
, specifically the 1,1-dimethyloctyl homologue
of CP 47,497. Both the dimethylheptyl and dimethyloctyl homologues were detected in different batches, with considerable variation in the concentration present in different samples that were analysed. The weaker dimethylhexyl and dimethylnonyl homologues were not found in any batches of smoking blends tested, but have been legally scheduled alongside the others in some jurisdictions, to forestall any potential use for this purpose. The 1,1-dimethyloctyl homologue of CP 47,497 is in fact several times more potent than the parent compound, which is somewhat unexpected as the 1,1-dimethylheptyl is the most potent substituent in classical cannabinoid compounds such as HU-210
. The unapproved use of these compounds in herbal smoking blends has led to a resurgence in legitimate scientific research into their use, and consequently the C8 homologue of CP 47,497 has been assigned a proper name, cannabicyclohexanol
.
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
in the 1980s. It has analgesic
Analgesic
An analgesic is any member of the group of drugs used to relieve pain . The word analgesic derives from Greek an- and algos ....
effects and is used in scientific research. It is a potent CB1 agonist with a Kd
Dissociation constant
In chemistry, biochemistry, and pharmacology, a dissociation constant is a specific type of equilibrium constant that measures the propensity of a larger object to separate reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into...
of 2.1nM.
Homologue
On the 19th of January 2009, the University of Freiburg in Germany announced that an analogAnalog (chemistry)
In chemistry, a structural analog , also known as chemical analog or simply analog, is a compound having a structure similar to that of another one, but differing from it in respect of a certain component. It can differ in one or more atoms, functional groups, or substructures, which are replaced...
of CP 47,497 is the main active ingredient in the herbal "incense" product Spice
Spice (drug)
Synthetic cannabis is a psychoactive herbal and chemical product which, when consumed, mimics the effects of cannabis. It is best known by the brand names K2 and Spice, both of which have largely become genericized trademarks used to refer to any synthetic cannabis product...
, specifically the 1,1-dimethyloctyl homologue
Homology (chemistry)
In chemistry, homology refers to the appearance of homologues. A homologue is a compound belonging to a series of compounds differing from each other by a repeating unit, such as a methylene group, a peptide residue, etcetera....
of CP 47,497. Both the dimethylheptyl and dimethyloctyl homologues were detected in different batches, with considerable variation in the concentration present in different samples that were analysed. The weaker dimethylhexyl and dimethylnonyl homologues were not found in any batches of smoking blends tested, but have been legally scheduled alongside the others in some jurisdictions, to forestall any potential use for this purpose. The 1,1-dimethyloctyl homologue of CP 47,497 is in fact several times more potent than the parent compound, which is somewhat unexpected as the 1,1-dimethylheptyl is the most potent substituent in classical cannabinoid compounds such as HU-210
HU-210
HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from -Myrtenol by the group led by Professor Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action...
. The unapproved use of these compounds in herbal smoking blends has led to a resurgence in legitimate scientific research into their use, and consequently the C8 homologue of CP 47,497 has been assigned a proper name, cannabicyclohexanol
Cannabicyclohexanol
Cannabicyclohexanol is a cannabinoid receptor agonist drug, developed by Pfizer in 1979...
.
Germany
On the 22nd January 2009, CP 47,497 was added to the German controlled drug schedules ("Betäubungsmittelgesetz"), along with its dimethylhexyl, dimethyloctyl and dimethylnonyl homologues.France
CP 47,497 and its C6, C8, and C9 homologues were made illegal in France on 24th of February 2009.Latvia
CP 47,497 and its C6, C8, and C9 homologues were made illegal in Latvia on 28 November 2009.Lithuania
CP 47,497 and its C6, C8, and C9 homologues were made illegal in Lithuania on 5th of June 2009.Sweden
CP 47,497 and its C6, C7, C8, and C9 homologues were made illegal in Sweden on 15th of September 2009.Romania
CP 47,497 and its C6, C7, C8, and C9 homologues were made illegal in Romania on 15th of February 2010.(Illegal Substances in Romania after 15.02.2010See also
- HHC9-nor-9β-Hydroxyhexahydrocannabinol9-nor-9β-Hydroxyhexahydrocannabinol , is a synthetic cannabinoid derivative which resulted from early modifications to the structure of THC, in a search for the simplest compound that could still fulfil the binding requirements to produce cannabis-like activity...
- (C8)-CP 47,497
- CP 50,556-1
- CP 55,244CP 55,244CP 55,244 is a compound which is a cannabinoid receptor agonist. It has analgesic effects and is used in scientific research. It is an extremely potent CB1 full agonist with a Ki of 0.21nM, making it more potent than the commonly used full agonist HU-210....
- CP 55,940CP 55,940CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC . CP 55,940 was created by Pfizer in 1974 but was never marketed. It is currently used to study the endocannabinoid system...
- CP-945,598