CP 55,940
Encyclopedia
CP 55,940 is a cannabinoid which mimics the effects of naturally occurring THC
(one of the psychoactive compounds found in marijuana
). CP 55,940 was created by Pfizer
in 1974 but was never marketed. It is currently used to study the endocannabinoid system
. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice. CP 55,940 is 45 times more potent than Δ9-THC, and fully antagonized by rimonabant
(SR141716A). CP 55,940 is considered a full agonist at both CB1 and CB2 receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at GPR55
, the putative "CB3" receptor.
There is no information on the dangers or neurotoxicity
of CP 55,940 except what can be inferred from its similarity to other cannabinoids, which typically exhibit neuroprotective properties.
Tetrahydrocannabinol
Tetrahydrocannabinol , also known as delta-9-tetrahydrocannabinol , Δ1-THC , or dronabinol, is the main chemical psychoactive substance found in the cannabis plant. It was first isolated in 1964. In pure form, it is a glassy solid when cold, and becomes viscous and sticky if warmed...
(one of the psychoactive compounds found in marijuana
Cannabis (drug)
Cannabis, also known as marijuana among many other names, refers to any number of preparations of the Cannabis plant intended for use as a psychoactive drug or for medicinal purposes. The English term marijuana comes from the Mexican Spanish word marihuana...
). CP 55,940 was created by Pfizer
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
in 1974 but was never marketed. It is currently used to study the endocannabinoid system
Endocannabinoid system
The endocannabinoid system refers to a group of neuromodulatory lipids and their receptors that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes:* The...
. Some effects that have been noted are a greatly decreased rates of lever pressing in exposed mice, and a greater reaction to opiates in exposed mice. CP 55,940 is 45 times more potent than Δ9-THC, and fully antagonized by rimonabant
Rimonabant
Rimonabant is an anorectic antiobesity drug that has been withdrawn from the market. It is an inverse agonist for the cannabinoid receptor CB1...
(SR141716A). CP 55,940 is considered a full agonist at both CB1 and CB2 receptors and has Ki values of 0.58nM and 0.68nM respectively, but is an antagonist at GPR55
GPR55
G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene.GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors.- History :...
, the putative "CB3" receptor.
There is no information on the dangers or neurotoxicity
Neurotoxicity
Neurotoxicity occurs when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system in such a way as to cause damage to nervous tissue. This can eventually disrupt or even kill neurons, key cells that transmit and process...
of CP 55,940 except what can be inferred from its similarity to other cannabinoids, which typically exhibit neuroprotective properties.