CORO1B
Encyclopedia
Coronin, actin binding protein, 1B also known as CORO1B is a protein
which in humans is encoded by the CORO1B gene
. Members of the coronin
family, such as CORO1B, are WD repeat
-containing actin
-binding proteins that regulate cell motility.
enriches at the leading edge of migrating cells. Studies related to this protein are as follows:
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
which in humans is encoded by the CORO1B gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. Members of the coronin
Coronin
Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to man.-Discovery:...
family, such as CORO1B, are WD repeat
WD40 repeat
The WD40 repeat is a short structural motif of approximately 40 amino acids , often terminating in a tryptophan-aspartic acid dipeptide...
-containing actin
Actin
Actin is a globular, roughly 42-kDa moonlighting protein found in all eukaryotic cells where it may be present at concentrations of over 100 μM. It is also one of the most highly-conserved proteins, differing by no more than 20% in species as diverse as algae and humans...
-binding proteins that regulate cell motility.
Function
A mammalian coroninCoronin
Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to man.-Discovery:...
enriches at the leading edge of migrating cells. Studies related to this protein are as follows:
- Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia.
- F-actin binding is essential for coronin 1B function in vivo.
- Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge.
- Phosphorylation of coronin 1B by protein kinase C regulates interaction with Arp2/3 and cell motility.
- In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury.
- Isolation, cloning, and characterization of a new mammalian coronin family member, coroninse, which is regulated within the protein kinase C signaling pathway.