Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone

Atovaquone

Atovaquone is a chemical compound that belongs to the class of naphthalenes. Atovaquone is a hydroxy-1,4-naphthoquinone, an analog of ubiquinone, with antipneumocystic activity. Its average wholesale price is about US$2.13 per standard 250 mg. tablet...

. It is a promising compound for the therapy and prophylaxis of all forms of theileriosis

Theileriosis

* East coast fever * Tropical theileriosis * Corridor disease -External links:*...

. Buparvaquone has been shown to have anti-leishmania

Leishmania

Leishmania is a genus of Trypanosomatid protozoa, and is the parasite responsible for the disease leishmaniasis. It is spread through sandflies of the genus Phlebotomus in the Old World, and of the genus Lutzomyia in the New World. Their primary hosts are vertebrates; Leishmania commonly infects...

l activity in vitro. It can be used to treat bovine East Coast fever

East Coast fever

-Introduction:East Coast fever is a disease of cattle, sheep and goats caused by the protozoan parasite Theileria parva. The term excludes diseases caused by other Theileria, such as tropical theileriosis , caused by T. annulata, and human theileriosis, caused by T...

 protozoal in-vitro, along with the only other substance known - Peganum Harmala.

It is the only really efficient commercial therapy product in bovine theileriosis

Theileriosis

* East coast fever * Tropical theileriosis * Corridor disease -External links:*...

, where it is used since the late 1980s.

Industrial production

It was first produced in Great Britain

Great Britain

Great Britain or Britain is an island situated to the northwest of Continental Europe. It is the ninth largest island in the world, and the largest European island, as well as the largest of the British Isles...

, then in Germany

Germany

Germany , officially the Federal Republic of Germany , is a federal parliamentary republic in Europe. The country consists of 16 states while the capital and largest city is Berlin. Germany covers an area of 357,021 km2 and has a largely temperate seasonal climate...

. It came out of license in the mid 2000s, and was then produced in different countries, e.g. India

India

India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...

 and RAZAK labs co. of Iran

Iran

Iran , officially the Islamic Republic of Iran , is a country in Southern and Western Asia. The name "Iran" has been in use natively since the Sassanian era and came into use internationally in 1935, before which the country was known to the Western world as Persia...

Use in bovine theileriosis

At unique dose of 2,5 mg/kg, recovery rate of curable cases is 90 to 98 %.
In tropical theileriosis

Tropical theileriosis

Tropical theileriosis or Mediterranean theileriosis is a theileriosis of cattle from the Mediterranean and Middle East area, from Morocco to Western parts of India and China....

, a dosage of 2.0 mg/kg has the same efficiency.
Body temperature returns to normal in two days (but only after 5 days in some cases).
Parasitemia lowers from 12 % (D0) to 5 % (D1), than to 1 % (D5) and is nul at D7.