Bradford sweets poisoning
Encyclopedia
The 1858 Bradford sweets poisoning was the accidental arsenic poisoning
Arsenic poisoning
Arsenic poisoning is a medical condition caused by increased levels of the element arsenic in the body. Arsenic interferes with cellular longevity by allosteric inhibition of an essential metabolic enzyme...

 of more than 200 people in Bradford
Bradford
Bradford lies at the heart of the City of Bradford, a metropolitan borough of West Yorkshire, in Northern England. It is situated in the foothills of the Pennines, west of Leeds, and northwest of Wakefield. Bradford became a municipal borough in 1847, and received its charter as a city in 1897...

, England
England
England is a country that is part of the United Kingdom. It shares land borders with Scotland to the north and Wales to the west; the Irish Sea is to the north west, the Celtic Sea to the south west, with the North Sea to the east and the English Channel to the south separating it from continental...

 in 1858; an estimated 20 people died when sweets
Confectionery
Confectionery is the set of food items that are rich in sugar, any one or type of which is called a confection. Modern usage may include substances rich in artificial sweeteners as well...

 accidentally made with arsenic
Arsenic
Arsenic is a chemical element with the symbol As, atomic number 33 and relative atomic mass 74.92. Arsenic occurs in many minerals, usually in conjunction with sulfur and metals, and also as a pure elemental crystal. It was first documented by Albertus Magnus in 1250.Arsenic is a metalloid...

 were sold from a market stall. The event contributed to the passage of the Pharmacy Act 1868 in the United Kingdom and legislation regulating the adulteration of foodstuffs.

Background

William Hardaker, known to locals as "Humbug Billy", sold sweets from a stall in the Green Market in central Bradford (now the site of Bradford's Arndale Centre, named Kirkgate Market
Leeds Kirkgate Market
Leeds Kirkgate Market is a market in Leeds, West Yorkshire, England located on Vicar Lane. It is the largest covered market in Europe. There are currently 800 stalls which attract over 100,000 visitors a week.-History:...

). Hardaker purchased his supplies from Joseph Neal, who made the sweets (or "lozenges") on Stone Street a few hundred yards to the north. The lozenges in question were peppermint humbug
Humbug (sweet)
Humbugs are a traditional hard boiled sweet available in the United Kingdom, Ireland, Canada, Australia and New Zealand. They are usually flavoured with peppermint and striped in two different colours . They have a hard outside and a soft toffee centre...

s, made of peppermint oil incorporated into a base of – in theory – sugar and gum
Natural gum
Natural gums are polysaccharides of natural origin, capable of causing a large viscosity increase in solution, even at small concentrations. In the food industry they are used as thickening agents, gelling agents, emulsifying agents, and stabilizers...

. However, sugar was expensive and so Neal would substitute a cheaper, inert substance known as "daft" for the sugar. The adulteration of foodstuffs with "daft" was common practice at the time. Ian Jones reports that "the precise identity of "daft" was variable: plaster of Paris, powdered limestone
Limestone
Limestone is a sedimentary rock composed largely of the minerals calcite and aragonite, which are different crystal forms of calcium carbonate . Many limestones are composed from skeletal fragments of marine organisms such as coral or foraminifera....

 and sulphate of lime had been reported."

Accidental poisoning

On the occasion in question, Neal sent the lodger who lived at his house – James Archer – to collect daft for Hardaker's humbugs from druggist Charles Hodgson, whose pharmacy was located at Baildon Bridge in Shipley
Shipley, West Yorkshire
Shipley is a town in West Yorkshire, England, by the River Aire and the Leeds and Liverpool Canal, north of Bradford and north-west of Leeds....

. Hodgson was at his pharmacy, but did not serve Archer owing to illness and so his requests were seen to by William Goddard. He went to Hodgson as he was unclear on where the "daft" was to be found, and was told that it was in a cask in one corner of the cellar. However, rather than "daft", Goddard sold Archer 12 pounds of arsenic trioxide
Arsenic trioxide
Arsenic trioxide is the inorganic compound with the formula As2O3. This commercially important oxide of arsenic is the main precursor to other arsenic compounds, including organoarsenic compounds. Approximately 50,000 tonnes are produced annually...

.

The mistake remained undetected even during manufacture of the sweets by James Appleton, an "experienced sweetmaker" employed by Neal, though Appleton did observe that the finished product looked different from the usual humbugs; reportedly, he was suffering symptoms of illness during the sweet-making process. Reportedly, Appleton mixed the 12 lb of arsenic with 40 lb of sugar and 4 lb of gum to make the sweets. Forty lb of lozenges were sold to Hardaker who also noticed the sweets looked unusual and used this to obtain a discount from Neal. Like Appleton, Hardaker, as one of the first to taste the sweets, also promptly became ill.

Regardless, Hardaker sold 5 lb of the sweets from his market stall that night – reportedly at a price of three halfpence
Three halfpence (British coin)
The British three halfpence was a silver coin worth 1½d or 1/160th of a pound produced for circulation in the British colonies, mainly in Ceylon and the West Indies in each year between 1834 and 1843, and also in 1860 and 1862...

 for two ounces. Of those who purchased and ate the sweets, around 20 people died with a further 200 or so becoming severely ill with arsenic poisoning within a day or so.

Consequences

Originally the first deaths – those of two children – were thought to be owing to cholera
Cholera
Cholera is an infection of the small intestine that is caused by the bacterium Vibrio cholerae. The main symptoms are profuse watery diarrhea and vomiting. Transmission occurs primarily by drinking or eating water or food that has been contaminated by the diarrhea of an infected person or the feces...

, a major problem in Britain at the time; but the growing number of casualties soon showed that the purchase of lozenges from Hardaker's stall was the cause, and from there the trail led to Neal and Hodgson. Goddard was arrested and stood before magistrates in the court house in Bradford on 1 November with Hodgson and Neal later committed for trial with Goddard on a charge of manslaughter
Manslaughter
Manslaughter is a legal term for the killing of a human being, in a manner considered by law as less culpable than murder. The distinction between murder and manslaughter is said to have first been made by the Ancient Athenian lawmaker Dracon in the 7th century BC.The law generally differentiates...

. Dr John Bell identified arsenic as the cause, and this was confirmed by Felix Rimmington, a prominent chemist and druggist and analytical chemist. Rimmington estimated that each humbug contained between 11 and 16 grains
Grain (measure)
A grain is a unit of measurement of mass that is nominally based upon the mass of a single seed of a cereal. From the Bronze Age into the Renaissance the average masses of wheat and barley grains were part of the legal definition of units of mass. However, there is no evidence of any country ever...

 (0.713 and 1.037 grams) of arsenic, though a contemporary account suggests 9 grains (0.5831 grams), with 4.5 grains (0.292 grams) being a lethal dose. As such, each lozenge would have contained enough arsenic to kill two people, and enough distributed by Hardaker in total to kill 2,000. The prosecution against Goddard and Neal was later withdrawn and Hodgson was acquitted when the case was considered at York Assizes on 21 December 1858.

The tragedy and resulting public outcry was a major contributing factor to The Pharmacy Act 1868 which recognized the chemist and druggist as the custodian and seller of named poisons (as medicine was then formally known). The requirement for record keeping and the requirement to obtain the signature of the purchaser is currently upheld under the Poisons Act 1972
Poisons Act 1972
The Poisons Act 1972 is an Act of the Parliament of the United Kingdom making provisions for the sale of non-medicinal poisons, and the involvement of Local Authorities and the Royal Pharmaceutical Society of Great Britain in their regulation.The act refers to the Pharmacy and Poisons Act 1933,...

 for "non medicinal" poisons. W. E. Gladstone
William Ewart Gladstone
William Ewart Gladstone FRS FSS was a British Liberal statesman. In a career lasting over sixty years, he served as Prime Minister four separate times , more than any other person. Gladstone was also Britain's oldest Prime Minister, 84 years old when he resigned for the last time...

's ministry of 1868–1874 also brought in legislation regulating the adulteration of foodstuffs as a result of the events.

Further reading

  • Holloway SWF. Royal Pharmaceutical Society of Great Britain 1841–1991. A Political and Social History. London: Pharmaceutical Press: 1991. pp 221–30.
  • Jones, Ian F. Arsenic and the Bradford poisonings of 1858. The Pharmaceutical Journal, Vol 265 No 7128, p. 938-93.
  • Sheeran G. The Bradford Poisoning of 1858. Halifax: Ryburn Publishing Ltd; 1992.
  • "Wholesale poisoning by arsenic at Bradford." Pharm J 1858; 18:340-43.
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